【Abstract】ObjectiveTo investigate the effects of high molecular bio-degradable film on preventing peritoneal adhesion.
MethodsOne hundred and twenty rats were divided into control group, non-bio-degradable film group and polycaprolactone (PCL) group. Animal models of peritoneal adhesion made by operations on rats serve as control group. In the study, non-bio-degradable film and biodegradable, namely PCL films sensitive to pseudomonas enzyme, were put into the opening of peritoneum. The effect of the films on peritoneal adhesion was examined on 1, 3, 7 and 30 d after operation.
ResultsPeritoneal adhesion was found in all the rats of control group and very low in PCL group and non-bio-degradable film group.
ConclusionPCL film can effectively prevent the formation of postoperative peritoneal adhesion.
Citation：
ZHANG Ping,DU Xiaohong,YANG Bin.. Prevention of Peritoneal Adhesion Formation with Biomaterial-Degradable Polycaprolactone Film. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(2): 194-196. doi:
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- 1. Almdahl SM, Burhol PG. Peritoneal adhesions: causes and prevention [Ｊ]. Dig Dis， 1990; 8(1)∶37.
- 2. Trebuchel G, Lechaux D, Lecalve JL. Laparoscopic left colon resection for diverticular disease [Ｊ]. Surg Endosc， 2002; 16(1)∶18.
- 3. Haney AF, Doty E. The formation of coalescing peritoneal adhesions requires injury to both contacting peritoneal surfaces [Ｊ]. Fertil Steril， 1994; 61(4)∶767.
- 4. Inoue K, Makuuchi M, Takayama T, et al. Longterm survival and prognostic factors in the surgical treatment of massforming type cholangiocarcinoma [Ｊ]. Surgery, 2000; 127(5)∶498.
- 5. Berdah SV, Delpero JR, Garcia S, et al. A western surgical experience of peripheral cholangiocarcinoma [Ｊ]. Br J Surg, 1996; 83(11)∶1517.
