Value of Serum Thyroglobulin in Diagnosis and Treatment of Differentiated Thyroid Cancer Patients_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Xiaoyi.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China;

Corresponding author：

Keywords：

Thyroglobulin Differentiated thyroid cancer Diagnosis Treatment

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【Abstract】ObjectiveTo discuss the value of thyroglobulin (TG) in diagnosis and treatment of differentiated thyroid cancer (DTC) patients.
MethodsLiteratures on measurement and clinical application of serum TG were reviewed.
ResultsImmunometric assay (IMA) was adopted by most clinical lab.TG antibody （TGAb） should be measured in the same sample of DTC patient.TG detection before operation is of less value in confirming diagnosis of DTC, but is helpful in differential diagnosis of histopathological type of DTC.TG detection after operation is very important in patients who had undergone total thyroidectomy.Monitoring TG after thyroid hormone withdrawal or recombinant human TSH stimulation is more sensitive to identify tumor recurrence.
ConclusionMonitoring TG after total thyroidectomy has great value in followup of DTC patients.

Citation： LI Xiaoyi.. Value of Serum Thyroglobulin in Diagnosis and Treatment of Differentiated Thyroid Cancer Patients. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(3): 265-267. doi: Copy

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29.	Mazzaferri EL, Kloos RT. Using recombinant human TSH in the management of welldifferentiated thyroid cancer: current strategies and future directions [J].
30.	Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for lowrisk patients with papillary thyroid carcinoma [J].
31.	David A, Blotta A, Bondanelli M, et al.
32.	Cailleux AF, Baudin E, Travagli JP, et al. Is diagnostic iodine131 scanning useful after total thyroid ablation for differentiated thyroid cancer?.
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34.	Haugen BR, Pacini F, Reiners C, et al. A comparison of recombinant human thyrotropin and thyroid hormone withdrawal for the detection of thyroid remnant or cancer [J].
35.	Mazzaferri EL, Massoll N.Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin [J].
36.	Verburg FA, Lips CJ, Lentjes EG, et al. Detection of circulating TGmRNA in the followup of papillary and follicular thyroid cancer: how useful is it? [J].

1. [J]. J Clin Endocrinol Metab, 2005; 90(10)∶5566.
2. Endocrinol Metab Clin North Am, 1995; 24(4)∶841.
3. J Clin Endocrinol Metab, 1998; 83(4)∶1121.
4. J Clin Endocrinol Metab, 2004; 89(8)∶3702.
5. Clin Endocrinol (Oxf), 1979; 10(1)∶17.
6. Eur J Surg Oncol, 1998; 24(6)∶553.
7. Br J Cancer, 1988; 57(1)∶105.
8. J Endocrinol Invest, 1999; 22(11 Suppl)∶3.
9. Thyroid, 2000; 10(9)∶767.
10. J Clin Endocrinol Metab, 2003; 88(4)∶1433.
11. Serum thyroglobulin concentrations and (131)I wholebody scan results in patients with differentiated thyroid carcinoma after administration of recombinant human thyroidstimulating hormone [J].
12. J Nucl Med, 2001; 42(10)∶1470.
13. [J]. J Clin Endocrinol Metab, 2000; 85(1)∶175.
14. Clin Endocrinol (Oxf), 2004; 61(2)∶163.
15. J Clin Endocrinol Metab, 1999; 84(11)∶3877.
16. Endocr Relat Cancer, 2002; 9(4)∶227.
17. Br J Cancer, 2004; 91(2)∶200.
18. Refetoff S, Lever EG. The value of serum thyroglobulin measurement in clinical practice [J]. JAMA, 1983; 250(17)∶2352.
19. Girelli ME, De Vido D. Serum thyroglobulin measurements in differentiated thyroid cancer [J]. Biomed Pharmacother, 2000; 54(6)∶330.
20. Spencer CA, Takeuchi M, Kazarosyan M. Current status and performance goals for serum thyroglobulin assays [J]. Clin Chem, 1996; 42(1)∶164.
21. Spencer CA, Bergoglio LM, Kazarosyan M, et al. Clinical impact of thyroglobulin (TG) and TG autoantibody method differences on the management of patients with differentiated thyroid carcinomas.
22. Spencer CA, Wang CC. Thyroglobulin measurement. Techniques, clinical benefits, and pitfalls [J].
23. Spencer CA, Takeuchi M, Kazarosyan M, et al. Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma [J].
24. Spencer CA. Challenges of serum thyroglobulin (TG) measurement in the presence of TG autoantibodies [J].
25. Shlossberg AH, Jacobson JC, Ibbertson HK.Serum thyroglobulin in the diagnosis and management of thyroid carcinoma [J].
26. Hocevar M, Auersperg M. Role of serum thyroglobulin in the preoperative evaluation of follicular thyroid tumours [J].
27. Thoresen SO, Myking O, Glattre E, et al. Serum thyroglobulin as a preclinical tumour marker in subgroups of thyroid cancer [J].
28. Schlumberger MJ. Diagnostic followup of welldifferentiated thyroid carcinoma: historical perspective and current status [J].
29. Mazzaferri EL, Kloos RT. Using recombinant human TSH in the management of welldifferentiated thyroid cancer: current strategies and future directions [J].
30. Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for lowrisk patients with papillary thyroid carcinoma [J].
31. David A, Blotta A, Bondanelli M, et al.
32. Cailleux AF, Baudin E, Travagli JP, et al. Is diagnostic iodine131 scanning useful after total thyroid ablation for differentiated thyroid cancer?.
33. Woodmansee WW, Haugen BR. Uses for recombinant human TSH in patients with thyroid cancer and nodular goiter [J].
34. Haugen BR, Pacini F, Reiners C, et al. A comparison of recombinant human thyrotropin and thyroid hormone withdrawal for the detection of thyroid remnant or cancer [J].
35. Mazzaferri EL, Massoll N.Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin [J].
36. Verburg FA, Lips CJ, Lentjes EG, et al. Detection of circulating TGmRNA in the followup of papillary and follicular thyroid cancer: how useful is it? [J].

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Value of Serum Thyroglobulin in Diagnosis and Treatment of Differentiated Thyroid Cancer Patients

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