Effect of Uroacitides on Cell Cycle Progression of Breast Cancer Cells_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHENG Wei ¹ , MA Lin ² , CHEN Lin ¹ , LI Rong ¹ , JIANG Yanyong. ¹

Department of General Surgery, General Hospital of PLA, Beijing 100853， China;

Corresponding author：

Keywords：

Breast cancer Uroacitide Retinoic acid Cell cycle

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【Abstract】ObjectiveTo investigate the effect of CDAⅡ on the cell cycle progression of breast cancer cells.
MethodsThe effects of CDAⅡ on growth curve, cell cycle progression and morphology of breast cancer cell lines MCF7 and MDAMB231 were observed when CDAⅡ and MCF7 or CDAⅡ and MDAMB231 were blended to cultivate in vitro, in comparison with the classical cell differentiation inducer ATRA.
ResultsCDAⅡ decreased the growth speed and inhibit proliferation ability in breast cancer cell lines MCF7 and MDAMB231.It caused G0/G1 phase block of cell cycle and reduced the rate of S phase of breast cancer cells.
ConclusionCDAⅡ has remarkable effect of anticellproliferation and can induce cell cycle block of G0/G1 on breast cancer cells. This results provide experimental bases for the treatment of breast cancer with CDAⅡ.

Citation： ZHENG Wei,MA Lin,CHEN Lin,LI Rong,JIANG Yanyong.. Effect of Uroacitides on Cell Cycle Progression of Breast Cancer Cells. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(3): 268-270. doi: Copy

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3. Swami S, Raghavachari N, Muller UR, et al. Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray [Ｊ]. Breast Cancer Res Treat, 2003; 80(1)∶49.
4. Wang JJ, Chang YF, Chern YT, et al. Study of in vitro and in vivo effects of 1,6Bis[4(4amino3hydroxyphenoxy)phenyl]diamantane (DPD), a novel cytostatic and differentiation inducing agent, on human colon cancer cells [Ｊ]. Br J Cancer, 2003; 89(10)∶1995.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Uroacitides on Cell Cycle Progression of Breast Cancer Cells

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