Expression of Tob mRNA in Human Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WU Dianchao , ZHOU Zongguang , ZHENG Xuelian , WANG Junfeng.

Department of General Surgery &;
Division of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Colorectal cancer Tob mRNA expression

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【Abstract】ObjectiveTo investigate the expression of Tob mRNA in human colorectal cancer tissues, and their corresponding paracancerous normal tissues which was 10 cm above the tumor and pathologically proved and to explore the role of Tob mRNA in the pathogenesis of colorectal cancer.
MethodsQuantitative real time RTPCR was used to detect the expression of Tob mRNA in 31 colorectal cancers.
ResultsCompared with paracancerous tissue, the expression of Tob mRNA in colorectal cancer tissues was significantly increased. Moreover, the expression levels of Tob in Dukes A, B, C, D were 1.146±0.067, 1.120±0.073, 1.052±0.020 and 1.047±0.010 respectively. Analyzed by oneway ANOVA, there were significant differences in expression of Tob in different Dukes stage.
ConclusionThe upregulation expression of Tob mRNA may be closely associated with tumorigenesis of colorectal carcinoma.

Citation： WU Dianchao,ZHOU Zongguang,ZHENG Xuelian,WANG Junfeng.. Expression of Tob mRNA in Human Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(3): 302-304. doi: Copy

1.	Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis [Ｊ]. Cell, 1990; 61(5)∶759.
2.	Matsuda S, KawamuraTsuzuku J, Ohsugi M, et al. Tob, a novel protein that interacts with p185erbB2, is associated with antiproliferative activity [Ｊ]. Oncogene, 1996; 12(4)∶705.
3.	Iwanaga K, Sueoka N, Sato A, et al. Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer [Ｊ]. Cancer Lett, 2003; 202(1)∶71.
4.	来茂德. 中国结直肠癌发生发展相关基因 [Ｊ]. 世界华人消化杂志， 2001； 9（11）∶1227.
5.	Matsuda S, Rouault J, Magaud J, et al. In search of a function for the TIS21/PC3/BTG1/TOB family [Ｊ]. FEBS Lett, 2001; 497(2-3)∶67.
6.	Fong KM, Kida Y, Zimmerman PV, et al. Loss of heterozygosity frequently affects chromosome 17q in nonsmall cell lung cancer [Ｊ]. Cancer Res, 1995; 55(19)∶4268.
7.	Yoshida Y, Nakamura T, Komoda M, et al. Mice lacking a transcriptional corepressor Tob are predisposed to cancer [Ｊ]. Genes Dev, 2003; 17(10)∶1201.
8.	Ahn SH, Sawada H, Ro JY, et al. Differential expression of annexin I in human mammary ductal epithelial cells in normal and benign and malignant breast tissues [Ｊ]. Clin Exp Metastasis, 1997; 15(2)∶151.
9.	Masaki T, Tokuda M, Ohnishi M, et al. Enhanced expression of the protein kinase substrate annexin in human hepatocellular carcinoma [Ｊ]. Hepatology, 1996; 24(1)∶72.
10.	Xia SH, Hu LP, Hu H, et al. Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but downregulated in esophageal squamous cell carcinomas [Ｊ]. Oncogene, 2002; 21(43)∶6641.
11.	Paweletz CP, Ornstein DK, Roth MJ, et al. Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma [Ｊ]. Cancer Res, 2000; 60(22)∶6293.
12.	Roninson IB. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumourpromoting activities of stromal fibroblasts [Ｊ]. Cancer Lett, 2002; 179(1)∶1.

1. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis [Ｊ]. Cell, 1990; 61(5)∶759.
2. Matsuda S, KawamuraTsuzuku J, Ohsugi M, et al. Tob, a novel protein that interacts with p185erbB2, is associated with antiproliferative activity [Ｊ]. Oncogene, 1996; 12(4)∶705.
3. Iwanaga K, Sueoka N, Sato A, et al. Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer [Ｊ]. Cancer Lett, 2003; 202(1)∶71.
4. 来茂德. 中国结直肠癌发生发展相关基因 [Ｊ]. 世界华人消化杂志， 2001； 9（11）∶1227.
5. Matsuda S, Rouault J, Magaud J, et al. In search of a function for the TIS21/PC3/BTG1/TOB family [Ｊ]. FEBS Lett, 2001; 497(2-3)∶67.
6. Fong KM, Kida Y, Zimmerman PV, et al. Loss of heterozygosity frequently affects chromosome 17q in nonsmall cell lung cancer [Ｊ]. Cancer Res, 1995; 55(19)∶4268.
7. Yoshida Y, Nakamura T, Komoda M, et al. Mice lacking a transcriptional corepressor Tob are predisposed to cancer [Ｊ]. Genes Dev, 2003; 17(10)∶1201.
8. Ahn SH, Sawada H, Ro JY, et al. Differential expression of annexin I in human mammary ductal epithelial cells in normal and benign and malignant breast tissues [Ｊ]. Clin Exp Metastasis, 1997; 15(2)∶151.
9. Masaki T, Tokuda M, Ohnishi M, et al. Enhanced expression of the protein kinase substrate annexin in human hepatocellular carcinoma [Ｊ]. Hepatology, 1996; 24(1)∶72.
10. Xia SH, Hu LP, Hu H, et al. Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but downregulated in esophageal squamous cell carcinomas [Ｊ]. Oncogene, 2002; 21(43)∶6641.
11. Paweletz CP, Ornstein DK, Roth MJ, et al. Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma [Ｊ]. Cancer Res, 2000; 60(22)∶6293.
12. Roninson IB. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumourpromoting activities of stromal fibroblasts [Ｊ]. Cancer Lett, 2002; 179(1)∶1.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Tob mRNA in Human Colorectal Cancer

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