Effects of Cholecystokinin on Diabetes Mellitus Complicated with Cholecystolithiasis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SUN Dengqun , MENG Xiangling.

Department of General Surgery， The First Affiliated Hospital， Anhui Medical University， Hefei 230032， China;

Corresponding author：

Keywords：

Cholecystokinin Receptor Diabetes mellitus Cholecystolithiasis

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【Abstract】ObjectiveTo investigate the effects of cholecystokinin （CCK） on diabetes mellitus with cholecystolithiasis.
MethodsRelevant literatures of recent years were reviewed.
ResultsCCK exists widely in human body．On the one hand, CCK enhances cholecystolithiasis by causing diabetes. On the other hand, its pathological changes can also lead to cholecystolithiasis. Besides, it is possibility that the CCKrelated gene abnormality is the common cause of diabetes and cholecystolithiasis.
ConclusionCCK plays an important role in diabetes mellitus complicated with cholecystolithiasis. However, there is much yet to be known about CCK．

Citation： SUN Dengqun,MENG Xiangling.. Effects of Cholecystokinin on Diabetes Mellitus Complicated with Cholecystolithiasis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(4): 406-408. doi: Copy

1.	[J]. Dig Dis Sci， 2004; 49(7-8)∶1342.
2.	[J]. Ann Surg， 2002; 235(6)∶842.
3.	[J]. J Gastroenterol, 2002; 37(14)∶102.
4.	Dig Dis Sci， 2003; 48(10)∶1944.
5.	[J]. Eur J Intern Med, 2002; 13(2)∶123.
6.	Pagliarulo M, Fornari F, Fraquelli M, et al. Gallstone disease and related risk factors in a large cohort of diabetic patients [J]. Dig Liver Dis， 2004; 36(2)∶130.
7.	Wang Y, Prpic V, Green GM, et al. Luminal CCKreleasing factor stimulates CCK release from human intestinal endocrine and STC1 cells [J]. Am J Physiol Gastrointest Liver Physid, 2002； 282(1)∶G16.
8.	Miyasaka K, Shinozaki H, Jimi A, et al. Amylase secretion from dispersed human pancreatic acini: neither cholecystokinin A nor cholecystokinin B receptors mediate amylase secretion in vitro [J]. Pancreas， 2002; 25(2)∶161.
9.	Kayacetin E, Kisakol G, Kaya A, et al. Realtime sonography for screening of gallbladder motility in diabetic patients: relation to autonomic and peripheral neuropathy [J]. Neuro Endocrinol Lett， 2003; 24(1-2)∶73.
10.	MathusVliegen EM, Van IerlandVan Leeuwen ML, Terpstra A. Determinants of gallbladder kinetics in obesity [J]. Dig Dis Sci， 2004; 49(1)∶9.
11.	Graewin SJ, Kiely JM, Lee KH, et al. Nonobese diabetic mice have diminished gallbladder motility and shortened crystal observation time [J]. J Gastrointest Surg， 2004; 8(7)∶824.
12.	Ruhl CE, Everhart JE. Association of diabetes, serum insulin, and Cpeptide with gallbladder disease [J]. Hepatology， 2000; 31(2)∶299.
13.	Sonobe K, Sakai T, Satoh M, et al. Control of gallbladder contractions by cholecystokinin through cholecystokininA receptors in the vagal pathway and gallbladder in the dog [J]. Regul Pept, 1995; 60(1)∶33.
14.	Kuntz E, Pinget M, Damge P. Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats [J]. JOP, 2004; 5(6)∶464.
15.	Graewin SJ, Lee KH, Kiely JM, et al. Gallbladder myocytes are short and cholecystokininresistant in obese diabetic mice [J]. Surgery， 2004; 136(2)∶431.
16.	Milewicz A, Mikulski E, Bidzinska B. Plasma insulin, cholecystokinin, galanin, neuropeptide Y and leptin levels in obese women with and without type 2 diabetes mellitus [J]. Int J Obes Relat Metab Disord, 2000; 24(6)∶S152.
17.	Guilmeau S, Buyse M, Tsocas A, et al. Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptincholecystokinin feedback loop [J]. Diabetes， 2003; 52(7)∶1664.
18.	Inoue H, Iannotti CA, Welling CM, et al. Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and noninsulindependent diabetes mellitus (NIDDM) [J]. Genomics, 1997; 42(2)∶331.
19.	MarchalVictorion S, Vionnet N, Escrieut C, et al. Genetic, pharmacological and functional analysis of cholecystokinin1 and cholecystokinin2 receptor polymorphism in type 2 diabetes and obese patients [J]. Pharmacogenetics, 2002； 12(1)∶23.
20.	Takiguchi S, Takata Y, Takahashi N, et al. A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene [J]. Am J Physiol， 1998; 274(2 Pt 1)∶E265.
21.	Funakoshi A, Miyasaka K, Yamamori S, et al. Gene structure of human cholecystokinin (CCK) typeA receptor: body fat content is related to CCK typeA receptor gene promoter polymorphism [J]. FEBS Lett， 2000; 466(2-3)∶264.
22.	Bi S, Moran TH. Actions of CCK in the controls of food intake and body weight: lessons from the CCKA receptor deficient OLETF rat [J]. Neuropeptides， 2002; 36(2-3)∶171.
23.	刘立人, 慕海峰，王盛江，等. 谷氨酰胺、胆囊收缩素预防完全胃肠外营养期间胆汁淤积的作用 [J]. 中国普外基础与临床杂志， 2000； 7（2）∶76.
24.	Pellegrini CA, Lewin M, Patti MG, et al. Gallbladder filling and response to cholecystokinin are not affected by vagotomy [J]. Surgery, 1985; 98(3)∶452.
25.	Glasbrenner B, DominguezMunoz JE, Nelson DK, et al. Postprandial release of cholecystokinin and pancreatic polypeptide in health and in gallstone disease: relationships with gallbladder contraction [J]. Am J Gastroenterol， 1994; 89(3)∶404.
26.	陈瑞新，王志伟，黄健，等. CCK8 在胆石症患者血浆中的水平变化及其临床意义 [J]. 放射免疫学杂志， 2004； 17（5）∶337.
27.	Deshpande SB, Gupta NK, Shukla VK. Cholelithiatic human gallbladders in vitro fail to respond to cholecystokinin but are responsive to carbachol, histamine, or electrical stimulation.
28.	Kano M, Shoda J, Satoh S, et al. Increased expression of gallbladder cholecystokinin: a receptor in prairie dogs fed a highcholesterol diet and its dissociation with decreased contractility in response to cholecystokinin [J]. J Lab Clin Med， 2002; 139(5)∶285.
29.	Nakeeb A, Comuzzie AG, Martin L, et al. Gallstones: genetics versus environment.
30.	Miyasaka K, Takata Y, Funakoshi A. Association of cholecystokinin A receptor gene polymorphism with cholelithiasis and the molecular mechanisms of this polymorphism.
31.	Sato N, Miyasaka K, Suzuki S, et al. Lack of cholecystokininA receptor enhanced gallstone formation: a study in CCKA receptor gene knockout mice [J].
32.	Wang DQ, Schmitz F, Kopin AS, et al. Targeted disruption of the murine cholecystokinin1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis [J]. J Clin Invest, 2004; 114(4)∶521.
33.	Bucceri AM, Calogero AE, Brogna A. Gallbladder and gastric emptying: relationship to cholecystokininemia in diabetics.

1. [J]. Dig Dis Sci， 2004; 49(7-8)∶1342.
2. [J]. Ann Surg， 2002; 235(6)∶842.
3. [J]. J Gastroenterol, 2002; 37(14)∶102.
4. Dig Dis Sci， 2003; 48(10)∶1944.
5. [J]. Eur J Intern Med, 2002; 13(2)∶123.
6. Pagliarulo M, Fornari F, Fraquelli M, et al. Gallstone disease and related risk factors in a large cohort of diabetic patients [J]. Dig Liver Dis， 2004; 36(2)∶130.
7. Wang Y, Prpic V, Green GM, et al. Luminal CCKreleasing factor stimulates CCK release from human intestinal endocrine and STC1 cells [J]. Am J Physiol Gastrointest Liver Physid, 2002； 282(1)∶G16.
8. Miyasaka K, Shinozaki H, Jimi A, et al. Amylase secretion from dispersed human pancreatic acini: neither cholecystokinin A nor cholecystokinin B receptors mediate amylase secretion in vitro [J]. Pancreas， 2002; 25(2)∶161.
9. Kayacetin E, Kisakol G, Kaya A, et al. Realtime sonography for screening of gallbladder motility in diabetic patients: relation to autonomic and peripheral neuropathy [J]. Neuro Endocrinol Lett， 2003; 24(1-2)∶73.
10. MathusVliegen EM, Van IerlandVan Leeuwen ML, Terpstra A. Determinants of gallbladder kinetics in obesity [J]. Dig Dis Sci， 2004; 49(1)∶9.
11. Graewin SJ, Kiely JM, Lee KH, et al. Nonobese diabetic mice have diminished gallbladder motility and shortened crystal observation time [J]. J Gastrointest Surg， 2004; 8(7)∶824.
12. Ruhl CE, Everhart JE. Association of diabetes, serum insulin, and Cpeptide with gallbladder disease [J]. Hepatology， 2000; 31(2)∶299.
13. Sonobe K, Sakai T, Satoh M, et al. Control of gallbladder contractions by cholecystokinin through cholecystokininA receptors in the vagal pathway and gallbladder in the dog [J]. Regul Pept, 1995; 60(1)∶33.
14. Kuntz E, Pinget M, Damge P. Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats [J]. JOP, 2004; 5(6)∶464.
15. Graewin SJ, Lee KH, Kiely JM, et al. Gallbladder myocytes are short and cholecystokininresistant in obese diabetic mice [J]. Surgery， 2004; 136(2)∶431.
16. Milewicz A, Mikulski E, Bidzinska B. Plasma insulin, cholecystokinin, galanin, neuropeptide Y and leptin levels in obese women with and without type 2 diabetes mellitus [J]. Int J Obes Relat Metab Disord, 2000; 24(6)∶S152.
17. Guilmeau S, Buyse M, Tsocas A, et al. Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptincholecystokinin feedback loop [J]. Diabetes， 2003; 52(7)∶1664.
18. Inoue H, Iannotti CA, Welling CM, et al. Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and noninsulindependent diabetes mellitus (NIDDM) [J]. Genomics, 1997; 42(2)∶331.
19. MarchalVictorion S, Vionnet N, Escrieut C, et al. Genetic, pharmacological and functional analysis of cholecystokinin1 and cholecystokinin2 receptor polymorphism in type 2 diabetes and obese patients [J]. Pharmacogenetics, 2002； 12(1)∶23.
20. Takiguchi S, Takata Y, Takahashi N, et al. A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene [J]. Am J Physiol， 1998; 274(2 Pt 1)∶E265.
21. Funakoshi A, Miyasaka K, Yamamori S, et al. Gene structure of human cholecystokinin (CCK) typeA receptor: body fat content is related to CCK typeA receptor gene promoter polymorphism [J]. FEBS Lett， 2000; 466(2-3)∶264.
22. Bi S, Moran TH. Actions of CCK in the controls of food intake and body weight: lessons from the CCKA receptor deficient OLETF rat [J]. Neuropeptides， 2002; 36(2-3)∶171.
23. 刘立人, 慕海峰，王盛江，等. 谷氨酰胺、胆囊收缩素预防完全胃肠外营养期间胆汁淤积的作用 [J]. 中国普外基础与临床杂志， 2000； 7（2）∶76.
24. Pellegrini CA, Lewin M, Patti MG, et al. Gallbladder filling and response to cholecystokinin are not affected by vagotomy [J]. Surgery, 1985; 98(3)∶452.
25. Glasbrenner B, DominguezMunoz JE, Nelson DK, et al. Postprandial release of cholecystokinin and pancreatic polypeptide in health and in gallstone disease: relationships with gallbladder contraction [J]. Am J Gastroenterol， 1994; 89(3)∶404.
26. 陈瑞新，王志伟，黄健，等. CCK8 在胆石症患者血浆中的水平变化及其临床意义 [J]. 放射免疫学杂志， 2004； 17（5）∶337.
27. Deshpande SB, Gupta NK, Shukla VK. Cholelithiatic human gallbladders in vitro fail to respond to cholecystokinin but are responsive to carbachol, histamine, or electrical stimulation.
28. Kano M, Shoda J, Satoh S, et al. Increased expression of gallbladder cholecystokinin: a receptor in prairie dogs fed a highcholesterol diet and its dissociation with decreased contractility in response to cholecystokinin [J]. J Lab Clin Med， 2002; 139(5)∶285.
29. Nakeeb A, Comuzzie AG, Martin L, et al. Gallstones: genetics versus environment.
30. Miyasaka K, Takata Y, Funakoshi A. Association of cholecystokinin A receptor gene polymorphism with cholelithiasis and the molecular mechanisms of this polymorphism.
31. Sato N, Miyasaka K, Suzuki S, et al. Lack of cholecystokininA receptor enhanced gallstone formation: a study in CCKA receptor gene knockout mice [J].
32. Wang DQ, Schmitz F, Kopin AS, et al. Targeted disruption of the murine cholecystokinin1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis [J]. J Clin Invest, 2004; 114(4)∶521.
33. Bucceri AM, Calogero AE, Brogna A. Gallbladder and gastric emptying: relationship to cholecystokininemia in diabetics.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of Cholecystokinin on Diabetes Mellitus Complicated with Cholecystolithiasis

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