Relationship of Magnetic Resonance DiffusionWeighted Imaging to Histology in Chronic Viral Hepatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Yang , SONG Bin , WU Bi.

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Chronic viral hepatitis Magnetic resonance imaging Diffusion-weighted imaging

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【Abstract】ObjectiveTo investigate the relationship of magnetic resonance diffusion-weighted imaging (DWI) to histology in the patients of chronic viral hepatitis.
MethodsThirty-five patients of chronic viral hepatitis who received liver biopsy and 10 healthy volunteers were included in this study. All of them underwent DWI on a 3.0T MRI device. Apparent diffusion coefficient (ADC) of the liver were measured respectively when b value were set as 100, 400, 600 and 800 s/mm2. Biopsy specimens were scored for fibrosis and necroinflammation according to the Knodell histology activity index (HAI).
ResultsWhen b value was set as 800 s/mm2, statistical difference was showed between the fibrosis group and the nonfibrosis group, statistical difference was also shown among the different degrees of necroinflammation and fibrosis.
ConclusionDWI is a valuable method for grading and staging of chronic viral hepatitis.

Citation： YANG Yang,SONG Bin,WU Bi.. Relationship of Magnetic Resonance DiffusionWeighted Imaging to Histology in Chronic Viral Hepatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(4): 469-473. doi: Copy

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4. Hepatology， 2002; 36(5 Suppl 1)∶S57.
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7. Radiology， 1988; 168(2)∶497.
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9. AJR Am J Roentgenol， 1999; 173(2)∶393.
10. Theoretical model for water diffusion in tissues [J].
11. Magn Reson Med， 1995; 33(5)∶697.
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13. Eur J Radiol， 2003; 45(3)∶214.
14. Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis [J]. 1981; 1(5)∶431.
15. Marcellin P, Asselah T, Boyer N.
16. Fontana RJ, Lok AS.
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20. Yamada I, Aung W, Himeno Y, et al. Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent motion echoplanar MR imaging [J]. Radiology， 1999; 210(3)∶617.
21. Le Bihan D, Breton E, Lallemand D, et al.
22. Kim T, Murakami T, Takahashi S, et al.
23. 张雪辉，梁碧玲，赵继泉，等. 肝脏常见病变弥散系数的初步研究 [J]. 中国医学影像技术, 2004； 20（1）∶26.
24. 孙希杰，全显跃，梁文，等. 3 cm以下的肝脏常见病变磁共振扩散成像的量化研究 [J]. 中华肿瘤杂志, 2004； 26（3）∶165.
25. Taouli B, Vilgrain V, Dumont E, et al. Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two singleshot echoplanar MR imaging sequences: prospective study in 66 patients [J]. Radiology， 2003; 226(1)∶71.
26. Szafer A, Zhong J, Gore JC.
27. Duong TQ, Ackerman JJ, Ying HS, et al. Evaluation of extraand intracellular apparent diffusion in normal and globally ischemic rat brain via 19F NMR [J]. Magn Reson Med， 1998; 40(1)∶1.
28. Chien D, Kwong KK, Gress DR, et al. MR diffusion imaging of cerebral infarction in humans [J]. AJNR Am J Neuroradiol， 1992; 13(4)∶1097.
29. Hein PA, Kremser C, Judmaier W, et al.
30. Koinuma M, Ohashi I, Hanafusa K, et al. Apparent diffusion coefficient measurements with diffusionweighted magnetic resonance imaging for evaluation of hepatic fibrosis [J]. J Magn Reson Imaging， 2005; 22(1)∶80.
31. Boulanger Y, Amara M, Lepanto L, et al. Diffusionweighted MR imaging of the liver of hepatitis C patients [J]. NMR Biomed， 2003; 16(3)∶132.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship of Magnetic Resonance DiffusionWeighted Imaging to Histology in Chronic Viral Hepatitis

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