Role of PPARδ in Pathogenesis of Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Lie , ZHONG Zongguang.

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Colorectal cancer Peroxisome pro1iferator-activated receptor Pathogenesis

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【Abstract】ObjectiveTo investigate the role of PPARδ in the pathogenesis of colorectal cancer.
MethodsLiteratures about PPARδ and the pathogenesis of colorectal cancer were reviewed and analyzed.
ResultsPPARδ is expressed in the nucleuses of glandular epithelia lining colon and rectum. It is normally suppressed by wild-type adenomatous polyposis coli (APC) but is up-regulated by enhanced β-catenin/T cell factor-4 (TCF-4) binding to TCF-4-responsive elements in the PPAR promoter when an inactivating APC mutation occurs, which indicates PPAR is a potential downstream target of the APC/β-catenin/TCF-4 signaling pathway in colorectal cancer. Consistent with PPAR’s role as an APC/β-catenin/TCF-4 target, some studies reported that PPAR mRNA is frequently overexpressed in colorectal cancers of both humans and rodent animals, which indicates that PPAR is relevant to the tumorigenesis of colorectal cancer.
ConclusionPPARδ is closely related with the pathogenesis of colorectal cancer.

Citation： YANG Lie,ZHONG Zongguang.. Role of PPARδ in Pathogenesis of Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(4): 484-486. doi: Copy

1.	Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators [J]. Nature， 1990; 347(6294)∶645.
2.	Yoshikawa T, Brkanac Z, Dupont BR, et al. Assignment of the human nuclear hormone receptor, NUC1 (PPARD), to chromosome 6p21.1-p21.2 [J]. Genomics, 1996; 35(3)∶637.
3.	Skogsberg J, Kannisto K, Roshani L, et al. Characterization of the human peroxisome proliferator activated receptor delta gene and its expression [J]. Int J Mol Med, 2000; 6(1)∶73.
4.	刘美莲，宋惠萍. 过氧化物酶增值激活受体研究的新进展 [J]. 国外医学·生理病理科学与临床分册， 2001； 21（5）∶413.
5.	钟芸诗，姚礼庆. 结直肠癌研究的新位点——PPAR的研究进展 [J]. 中国现代医学杂志， 2002; 12（13）∶37.
6.	Gupta RA, Tan J, Krause WF, et al. Prostacyclinmediated activation of peroxisome proliferatoractivated receptor delta in colorectal cancer [J]. Proc Natl Acad Sci USA, 2000; 97(24)∶13275.
7.	张延龄. 结直肠癌的发病机制 [J]. 国外医学·外科学分册， 2003; 30（2）∶96.
8.	张维，刘爽，徐宁志. Wnt信号传导通路及其在肿瘤发生中的作用 [J]. 世界华人消化杂志， 2002; 10（10）∶1201.
9.	孔民，白阳，王敬泽. Wnt信号传导途径及其与结直肠癌的关联 [J]. 细胞生物学杂志， 2003; 25（6）∶343.
10.	来茂德. 结直肠癌发生的分子机制研究进展 [J]. 中华病理学杂志， 2000; 29（6）∶450.
11.	钟芸诗，姚礼庆. 过氧化物酶体增值因子活化受体δ（PPARδ）在大肠癌中的表达及其意义——附80例临床分析 [J]. 中国现代医学杂志， 2003； 13（22）∶93.
12.	He TC, Chan TA, Vogelstein B, et al. PPAR delta is an APCregulated target of nonsteroidal antiinflammatory drugs [J]. Cell， 1999; 99(3)∶335.
13.	Hawcroft G, D’Amico M, Albanese C, et al. Indomethacin induces differential expression of betacatenin, gammacatenin and Tcell factor target genes in human colorectal cancer cells [J]. Carcinogenesis, 2002; 23(1)∶107.
14.	Shureiqi I, Jiang W, Zuo X, et al. The 15lipoxygenase1 product 13Shydroxyoctadecadienoic acid downregulates PPARdelta to induce apoptosis in colorectal cancer cells [J]. Proc Natl Acad Sci USA, 2003; 100(17)∶9968.
15.	张乾勇. 120PPAR的结构与功能及其生物学作用 [J]. 国外医学·卫生学分册， 2000； 27（5）∶284.
16.	Cox B, Murphey LJ, Zackert WE, et al. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione [J]. Biochim Biophys Acta, 2002; 1584(1)∶37.

1. Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators [J]. Nature， 1990; 347(6294)∶645.
2. Yoshikawa T, Brkanac Z, Dupont BR, et al. Assignment of the human nuclear hormone receptor, NUC1 (PPARD), to chromosome 6p21.1-p21.2 [J]. Genomics, 1996; 35(3)∶637.
3. Skogsberg J, Kannisto K, Roshani L, et al. Characterization of the human peroxisome proliferator activated receptor delta gene and its expression [J]. Int J Mol Med, 2000; 6(1)∶73.
4. 刘美莲，宋惠萍. 过氧化物酶增值激活受体研究的新进展 [J]. 国外医学·生理病理科学与临床分册， 2001； 21（5）∶413.
5. 钟芸诗，姚礼庆. 结直肠癌研究的新位点——PPAR的研究进展 [J]. 中国现代医学杂志， 2002; 12（13）∶37.
6. Gupta RA, Tan J, Krause WF, et al. Prostacyclinmediated activation of peroxisome proliferatoractivated receptor delta in colorectal cancer [J]. Proc Natl Acad Sci USA, 2000; 97(24)∶13275.
7. 张延龄. 结直肠癌的发病机制 [J]. 国外医学·外科学分册， 2003; 30（2）∶96.
8. 张维，刘爽，徐宁志. Wnt信号传导通路及其在肿瘤发生中的作用 [J]. 世界华人消化杂志， 2002; 10（10）∶1201.
9. 孔民，白阳，王敬泽. Wnt信号传导途径及其与结直肠癌的关联 [J]. 细胞生物学杂志， 2003; 25（6）∶343.
10. 来茂德. 结直肠癌发生的分子机制研究进展 [J]. 中华病理学杂志， 2000; 29（6）∶450.
11. 钟芸诗，姚礼庆. 过氧化物酶体增值因子活化受体δ（PPARδ）在大肠癌中的表达及其意义——附80例临床分析 [J]. 中国现代医学杂志， 2003； 13（22）∶93.
12. He TC, Chan TA, Vogelstein B, et al. PPAR delta is an APCregulated target of nonsteroidal antiinflammatory drugs [J]. Cell， 1999; 99(3)∶335.
13. Hawcroft G, D’Amico M, Albanese C, et al. Indomethacin induces differential expression of betacatenin, gammacatenin and Tcell factor target genes in human colorectal cancer cells [J]. Carcinogenesis, 2002; 23(1)∶107.
14. Shureiqi I, Jiang W, Zuo X, et al. The 15lipoxygenase1 product 13Shydroxyoctadecadienoic acid downregulates PPARdelta to induce apoptosis in colorectal cancer cells [J]. Proc Natl Acad Sci USA, 2003; 100(17)∶9968.
15. 张乾勇. 120PPAR的结构与功能及其生物学作用 [J]. 国外医学·卫生学分册， 2000； 27（5）∶284.
16. Cox B, Murphey LJ, Zackert WE, et al. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione [J]. Biochim Biophys Acta, 2002; 1584(1)∶37.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Role of PPARδ in Pathogenesis of Colorectal Cancer

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