Relationship Between Methylation of Tumor Suppressor Gene and Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Shaohui , DAI Dongqiu.

Department of Oncosurgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China;

Corresponding author：

Keywords：

Gastric cancerTumor suppressor geneMethylation

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【Abstract】　Objective　To investigate the relationship between methylation of tumor suppressor gene and gastric cancer. Methods　The literatures in recent years about the concept of methylation, its biological significance and the relationship between DNA methylation/demethylation and gastric cancer were reviewed. The effects of methylation of different tumor suppressor genes on gastric cancer were also analyzed. Results　The effect of aberrant methylation on the development and the progression of gastric cancer was still unclear but it was supposed that the inactivation of genes related with cell cycle regulation, mitotic checkpoint, apoptosis, DNA mismatch repair, metastasis suppression and so on might be attributable to the aberrant methylation in gastric cancer. Conclusion　Aberrant methylation of tumor suppressor genes plays an important role in the development and progression of gastric cancer. The status of methylation of tumor suppressor genes may be used as a useful molecule marker for diagnosis, assessing metastasis and evaluating prognosis, and demethylation could possibly be a new therapy for gastric cancer.

Citation： YANG Shaohui,DAI Dongqiu.. Relationship Between Methylation of Tumor Suppressor Gene and Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(5): 614-616. doi: Copy

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14.	Oue N, Shigeishi H, Kuniyasu H, et al. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma [J]. Int J Cancer， 2001; 93(6)∶805.
15.	Hong SH, Kim HG, Chung WB, et al. DNA hypermethylation of tumor-related genes in gastric carcinoma [J]. J Korean Med Sci， 2005; 20(2)∶236.
16.	Hazan RB, Qiao R, Keren R, et al. Cadherin switch in tumor progression [J]. Ann N Y Acad Sci， 2004; 1014∶155.
17.	郑志红，孙秀菊，邱广蓉，等. 胃癌癌前和发展阶段中E-cadherin基因的突变 [J]. 世界华人消化杂志， 2002; 10（2）∶153.
18.	郑志红，孙秀菊，马鸣超，等. 胃癌发展相关阶段中E-cadherin基因启动子甲基化及蛋白表达的研究 [J]. 遗传学报， 2003; 30（2）∶103.
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1. 　Reik W, Dean W, Walter J. Epigenetic reprogramming in ma-mmalian development [J]. Science， 2001; 293(5532)∶1089.
2. 　Robertson KD, Jones PA. DNA methylation: past， present and future directions [J]. Carcinogenesis, 2000; 21(3)∶461.
3. 　Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation of gene transcription [J].Cell Mol Life Sci， 2002; 59(2)∶241.
4. 　Yan L, Yang X, Davidson NE. Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer [J]. J Mammary Gland Biol Neoplasia， 2001; 6(2)∶183.
5. 　Pfeifer GP, Tang M, Denissenko MF. Mutation hotspots and DNA methylation [J]. Curr Top Microbiol Immunol， 2000; 249（1）∶1.
6. 　Kang GH, Lee S, Kim JS, et al. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis [J]. Lab Invest， 2003; 83(5)∶635.
7. 　Ding Y, Le XP, Zhang QX, et al. Methylation and mutation analysis of p16 gene in gastric cancer [J]. World J Gastroenterol， 2003; 9(3)∶423.
8. 　Lee JH, Park SJ, Abraham SC, et al. Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas [J]. Oncogene， 2004; 23(26)∶4646.
9. 　Lee TL, Leung WK, Chan MW, et al. Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma [J]. Clin Cancer Res， 2002; 8(6)∶1761.
10. 　Kang HC, Kim IJ, Park JH, et al. Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers [J]. Oncol Rep， 2004; 12(1)∶129.
11. 　Murai M, Toyota M, Suzuki H, et al. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer [J]. Clin Cancer Res， 2005; 11(3)∶1021.
12. 　Jung HY, Jung KC, Shim YH, et al. Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability [J]. Pathol Int， 2001; 51(6)∶445.
13. 　Nakajima T, Akiyama Y, Shiraishi J, et al. Age-related hypermethylation of the hMLH1 promoter in gastric cancers [J]. Int J Cancer， 2001; 94(2)∶208.
14. 　Oue N, Shigeishi H, Kuniyasu H, et al. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma [J]. Int J Cancer， 2001; 93(6)∶805.
15. 　Hong SH, Kim HG, Chung WB, et al. DNA hypermethylation of tumor-related genes in gastric carcinoma [J]. J Korean Med Sci， 2005; 20(2)∶236.
16. 　Hazan RB, Qiao R, Keren R, et al. Cadherin switch in tumor progression [J]. Ann N Y Acad Sci， 2004; 1014∶155.
17. 　郑志红，孙秀菊，邱广蓉，等. 胃癌癌前和发展阶段中E-cadherin基因的突变 [J]. 世界华人消化杂志， 2002; 10（2）∶153.
18. 　郑志红，孙秀菊，马鸣超，等. 胃癌发展相关阶段中E-cadherin基因启动子甲基化及蛋白表达的研究 [J]. 遗传学报， 2003; 30（2）∶103.
19. 　Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications [J]. Ann Intern Med, 2001; 134(7)∶573.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Methylation of Tumor Suppressor Gene and Gastric Cancer

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