Effects of Recombinant Human Growth Hormone on Hypoalbuminemia in Cirrhotic Rats after Partial Hepatectomy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LUO Shimin , LIANG Lijian , HU Wenjie.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Sun Yat-Sen University， Guangzhou 510080，China;

Corresponding author：

Keywords：

Liver cirrhosis Growth hormone Parenteral nutrition Albumin

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【Abstract】ObjectiveTo investigate the effects of rhGH on hypoalbuminemia in cirrhotic rats after partial hepatectomy.
MethodsThirty rats were randomly divided into normal control group (n=6), liver cirrhosis group (LC group, n=6), liver cirrhosis and hepatectomy group (LCH group,n=6), PN (parenteral nutrition) group (n=6， given PN after hepatectomy) and rhGH+PN group (n=6,given rhGH and PN after hepatectomy). Liver function and blood glucose were measured. The expression of ALB mRNA was detected by RTPCR. Liver Ki67 immunohistochemistry was studied.
ResultsCompared with PN group, serum ALP was lower; serum ALB and blood glucose were higher in rhGH+PN group. The expression of hepatic ALB mRNA was higher, and hepatic Ki67 labeling index was higher as well in this group.
ConclusionrhGH can improve hypoalbuminemia after partial hepatectomy in cirrhotic rats with partial hepatectomy.

Citation： LUO Shimin,LIANG Lijian,HU Wenjie.. Effects of Recombinant Human Growth Hormone on Hypoalbuminemia in Cirrhotic Rats after Partial Hepatectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(2): 158-161. doi: Copy

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8.	Dudrick SJ, Kavic SM. Hepatobiliary nutrition: history and future [Ｊ]. J Hepatobiliary Pancreat Surg， 2002; 9(4)459.
9.	Fan ST, Lo CM, Lai EC, et al. Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma [Ｊ]. N Engl J Med， 1994; 331(23)1547.
10.	Tsukishiro T, Shimizu Y, Higuchi K, et al. Effect of branchedchain amino acids on the composition and cytolytic activity of liverassociated lymphocytes in rats [Ｊ]. J Gastroenterol Hepatol， 2000; 15(8)849.
11.	Platell C, Kong SE, McCauley R, et al. Branchedchain amino acids [Ｊ]. J Gastroenterol Hepatol， 2000; 15(7)706.
12.	Shi J, Sekhar RV, Balasubramanyam A, et al. Short and longterm effects of growth hormone (GH) replacement on protein metabolism in GHdeficient adults [Ｊ]. J Clin Endocrinol Metab， 2003; 88(12)5827.
13.	Biolo G, Iscra F, Bosutti A, et al. Growth hormone decreases muscle glutamine production and stimulates protein synthesis in hypercatabolic patients [Ｊ]. Am J Physiol Endocrinol Metab, 2000; 279(2)E323.

1. 3Muller A, Machnik F, Zimmermann T, et al. Thioacetamideinduced cirrhosislike liver lesions in ratsusefulness and reliability of this animal model [Ｊ]. Exp Pathol， 1988; 34(4)229 4Tao RC, Yoshimura NN, Chinn IB, et al. Determination of intravenous nonprotein energy and nitrogen requirements in growing rats [Ｊ]. J Nutr， 1979; 109(5)904.
2. 黎介寿. 当前我国临床营养支持的误区与展望 [Ｊ]. 外科理论与实践， 2000； 5（1） 3.
3. Higgins GM, Anderson RM. Experimental pathology of the liver. I.Restoration of the liver of the white rat following partial surgical removal [Ｊ]. Arch Path, 1931; 12(2)186.
4. 罗时敏，梁力建. 全胃肠外营养对肝硬变大鼠肝脏的影响 [Ｊ]. 中国胃肠外科杂志， 1999； 2（1）49.
5. FranchArcas G. The meaning of hypoalbuminaemia in clinical practice [Ｊ]. Clin Nutr， 2001; 20(3)265.
6. Allison SP, Lobo DN, Stanga Z. The treatment of hypoalbuminaemia [Ｊ]. Clin Nutr， 2001; 20(3)275.
7. Anonymous. Human albumin administration in critically ill patients: systematic review of randomised controlled trials. Cochrane Injuries Group Albumin Reviewers [Ｊ]. BMJ， 1998; 317(7153)235.
8. Dudrick SJ, Kavic SM. Hepatobiliary nutrition: history and future [Ｊ]. J Hepatobiliary Pancreat Surg， 2002; 9(4)459.
9. Fan ST, Lo CM, Lai EC, et al. Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma [Ｊ]. N Engl J Med， 1994; 331(23)1547.
10. Tsukishiro T, Shimizu Y, Higuchi K, et al. Effect of branchedchain amino acids on the composition and cytolytic activity of liverassociated lymphocytes in rats [Ｊ]. J Gastroenterol Hepatol， 2000; 15(8)849.
11. Platell C, Kong SE, McCauley R, et al. Branchedchain amino acids [Ｊ]. J Gastroenterol Hepatol， 2000; 15(7)706.
12. Shi J, Sekhar RV, Balasubramanyam A, et al. Short and longterm effects of growth hormone (GH) replacement on protein metabolism in GHdeficient adults [Ｊ]. J Clin Endocrinol Metab， 2003; 88(12)5827.
13. Biolo G, Iscra F, Bosutti A, et al. Growth hormone decreases muscle glutamine production and stimulates protein synthesis in hypercatabolic patients [Ｊ]. Am J Physiol Endocrinol Metab, 2000; 279(2)E323.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of Recombinant Human Growth Hormone on Hypoalbuminemia in Cirrhotic Rats after Partial Hepatectomy

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