Intestinal Barrier Changes and Its Pathogenesis in Stress Conditions_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SUN Jingping , MA Hongsheng.

Department of Gastroenterology, West China Hospital, Sichuan University， Chengdu 610041， China;

Corresponding author：

Keywords：

Stress Intestinal barrier function Pathogenesis

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【Abstract】ObjectiveTo review the research advance of intestinal barrier changes and its pathogenesis in stress conditions.
MethodsThe literatures in recent years on the changes of the intestinal barrier,and its pathogenesis in stress conditions were reviewed.
Results In some severe stress conditions, such as trauma, severe inflammation and acute severe pancreatitis, etc, a series of pathophysiologic disorders of intestinal barrier， even systemic inflammatory response syndrome and multiple organ dysfunction syndrome or multiple organ failure were induced. The pathogenesis was a result of a series of neurologic, immunologic and endocrine factors making one another.
ConclusionRecognizing the changes and pathogenesis have an important clinical significance for treating and preventing the intestinal barrier dysfunction induced by stress.

Citation： SUN Jingping,MA Hongsheng.. Intestinal Barrier Changes and Its Pathogenesis in Stress Conditions. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(3): 314-316. doi: Copy

1.	Soderholm JD, Perdue MH. Stress and gastrointestinal tract. II. Stress and intestinal barrier function [J]. Am J Physiol Gastrointest Liver Physiol， 2001; 280(1)∶G7.
2.	Madara JL. Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctions [J]. J Membr Biol, 1990; 116(2)∶177.
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4.	Santos J, Saperas E, Mourelle M, et al. Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropinreleasing hormone in rats [J]. Gastroenterology, 1996; 111(6)∶1465.
5.	Saunders PR, Kosecka U, McKay DM, et al. Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine [J]. Am J Physiol, 1994; 267(5 Pt 1)∶G794.
6.	Castagliuolo I, Lamont JT, Qiu B, et al. Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells [J]. Am J Physiol, 1996; 271(5 Pt 1)∶G884.
7.	Deitch EA. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure [J]. Arch Surg, 1990; 125(3)∶403.
8.	Barclay GR, Turnberg LA. Effect of psychological stress on salt and water transport in the human jejunum [J]. Gastroenterology, 1987; 93(1)∶91.
9.	Wilson LM, Baldwin AL. Environmental stress causes mast cell degranulation, endothelial and epithelial changes, and edema in the rat intestinal mucosa [J]. Microcirculation, 1999; 6(3)∶189.
10.	Castagliuolo I, Wershil BK, Karalis K, et al. Colonic mucin release in response to immobilization stress is mast cell dependent [J]. Am J Physiol, 1998; 274(6 Pt 1)∶G1094.
11.	Saunders PR, Santos J, Hanssen NP, et al. Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH [J]. Dig Dis Sci, 2002; 47(1)∶208.
12.	Alptekin N, Seckin S, DogruAbbasoglu S, et al. Lipid peroxides, glutathione, gammaglutamylcysteine synthetase and gammaglutamyltranspeptidase activities in several tissues of rats following waterimmersion stress [J]. Pharmacol Res, 1996; 34(3-4)∶167.
13.	Anup R, Aparna V, Pulimood A, et al. Surgical stress and the small intestine: role of oxygen free radicals [J]. Surgery, 1999; 125(5)∶560.
14.	Li LS, Qu RY, Wang W, et al. Significance of changes of gastrointestinal peptides in blood and ileum of experimental spleen deficiency rats [J]. World J Gastroenterol, 2003; 9(3)∶553.
15.	Alican I, Kubes P. A critical role for nitric oxide in intestinal barrier function and dysfunction [J]. Am J Physiol, 1996; 270(2 Pt 1)∶G225.
16.	Papaconstantinou HT, Chung DH, Zhang W, et al. Prevention of mucosal atrophy: role of glutamine and caspases in apoptosis in intestinal epithelial cells [J]. J Gastrointest Surg, 2000; 4(4)∶416.

1. Soderholm JD, Perdue MH. Stress and gastrointestinal tract. II. Stress and intestinal barrier function [J]. Am J Physiol Gastrointest Liver Physiol， 2001; 280(1)∶G7.
2. Madara JL. Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctions [J]. J Membr Biol, 1990; 116(2)∶177.
3. Meddings JB, Swain MG. Environmental stressinduced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat [J]. Gastroenterology, 2000; 119(4)∶1019.
4. Santos J, Saperas E, Mourelle M, et al. Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropinreleasing hormone in rats [J]. Gastroenterology, 1996; 111(6)∶1465.
5. Saunders PR, Kosecka U, McKay DM, et al. Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine [J]. Am J Physiol, 1994; 267(5 Pt 1)∶G794.
6. Castagliuolo I, Lamont JT, Qiu B, et al. Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells [J]. Am J Physiol, 1996; 271(5 Pt 1)∶G884.
7. Deitch EA. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure [J]. Arch Surg, 1990; 125(3)∶403.
8. Barclay GR, Turnberg LA. Effect of psychological stress on salt and water transport in the human jejunum [J]. Gastroenterology, 1987; 93(1)∶91.
9. Wilson LM, Baldwin AL. Environmental stress causes mast cell degranulation, endothelial and epithelial changes, and edema in the rat intestinal mucosa [J]. Microcirculation, 1999; 6(3)∶189.
10. Castagliuolo I, Wershil BK, Karalis K, et al. Colonic mucin release in response to immobilization stress is mast cell dependent [J]. Am J Physiol, 1998; 274(6 Pt 1)∶G1094.
11. Saunders PR, Santos J, Hanssen NP, et al. Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH [J]. Dig Dis Sci, 2002; 47(1)∶208.
12. Alptekin N, Seckin S, DogruAbbasoglu S, et al. Lipid peroxides, glutathione, gammaglutamylcysteine synthetase and gammaglutamyltranspeptidase activities in several tissues of rats following waterimmersion stress [J]. Pharmacol Res, 1996; 34(3-4)∶167.
13. Anup R, Aparna V, Pulimood A, et al. Surgical stress and the small intestine: role of oxygen free radicals [J]. Surgery, 1999; 125(5)∶560.
14. Li LS, Qu RY, Wang W, et al. Significance of changes of gastrointestinal peptides in blood and ileum of experimental spleen deficiency rats [J]. World J Gastroenterol, 2003; 9(3)∶553.
15. Alican I, Kubes P. A critical role for nitric oxide in intestinal barrier function and dysfunction [J]. Am J Physiol, 1996; 270(2 Pt 1)∶G225.
16. Papaconstantinou HT, Chung DH, Zhang W, et al. Prevention of mucosal atrophy: role of glutamine and caspases in apoptosis in intestinal epithelial cells [J]. J Gastrointest Surg, 2000; 4(4)∶416.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Intestinal Barrier Changes and Its Pathogenesis in Stress Conditions

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