Relationship Between Anomalous Pancreaticobiliary Ductal Junction and Gallbladder Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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ZHOU Yanming , YANG Jiamei.

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Anomalous pancreaticobiliary ductal junction Gallbladder carcinoma

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【Abstract】ObjectiveTo explore the relationship between anomalous pancreaticobiliary ductal junction(APBDJ) and gallbladder carcinoma.
MethodsThe current related literatures were reviewed.
ResultsAPBDJ was associated with gallbladder carcinoma development. A proposed mechanism was free reflux of pancreatic juice into the gallbladder and molecular alterations of gallbladder epithelial cells.
ConclusionAPBDJ is a high risk factor for gallbladder carcinoma. Prophylactic cholecystectomy is recommended for patients with APBDJ.

Citation： ZHOU Yanming,YANG Jiamei.. Relationship Between Anomalous Pancreaticobiliary Ductal Junction and Gallbladder Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(4): 361-364. doi: Copy

1.	孟翔凌,何磊,徐阿曼,等. 胰胆管合流异常的临床意义 [J]. 中国普外基础与临床杂志, 2003; 10(5)∶451.
2.	Babbitt DP. Congenital choledochal cysts: new etiological concept based on anomalous relationships of the common bile duct and pancreatic bulb [J]. Ann Radiol (Paris), 1969; 12()∶231.
3.	Misra SP, Dwivedi M. Pancreaticobiliary ductal union [J]. Gut, 1990； 31(10)∶1144.
4.	The Japanese Study Group on Pancreaticobiliary Maljunction（JSPBM）. The committee of JSPBM for diagnostic criteria of pancreaticobiliary maljunction [J]. J Hepatobiliary Pancreat Surg, 1994; 1(3)∶219.
5.	Doty J, Hassall E, Fonkalsrud EW. Anomalous drainage of the common bile duct into the fourth portion of the duodenum. Clinical sequelae [J]. Arch Surg, 1985； 120(9)∶1077.
6.	Kato O, Hattori K, Suzuki T, et al. Clinical significance of anomalous pancreaticobiliary union [J]. Gastrointest Endosc, 1983； 29(2)∶94.
7.	Ono J, Sakoda K, Akita H. Surgical aspect ot cystic dilatation of the bile duct. An anomalous junction of the pancreaticobiliary tract in adults [J]. Ann Surg, 1982； 195(2)∶203.
8.	巫北海.胆胰管十二指肠连接区疾病 [J]. 中国医学计算机成像杂志, 1999; 5(4)∶228.
9.	Sasatomi E, Tokunaga O, Miyazaki K. Precancerous conditions of gallbladder carcinoma: overview of histopathologic characteristics and molecular genetic findings [J]. J Hepatobiliary Pancreat Surg, 2000; 7(6)∶556.
10.	Tashiro S, Imaizumi T, Ohkawa H, et al. Pancreaticobiliary maljunction: retrospective and nationwide survey in Japan [J]. J Hepatobiliary Pancreat Surg, 2003; 10(5)∶345.
11.	Wong KC, Lister J. Human fetal development of the hepatopancreatic duct junction——a possible explanation of congenital dilatation of the biliary tract [J]. J Pediatr Surg, 1981； 16(2)∶139.
12.	Matsumoto Y, Fujii H, Itakura J, et al. Pancreaticobiliary maljunction: etiologic concepts based on radiologic aspects [J]. Gastrointest Endosc, 2001； 53(6)∶614.
13.	Fujii H, Matsumoto Y, Yamamoto M, et al. Bile flow analysis by hepatobiliary scintigraphy in the terminal bile duct in patients with congenital malformations of the pancreaticobiliary ductal system [J]. Gastroenterol n, 1991； 26(2)∶201.
14.	Kim HJ, Kim MH, Lee SK, et al. Normal structure, variations, and anomalies of the pancreaticobiliary ducts of Koreans: a nationwide cooperative prospective study [J]. Gastrointest Endosc, 2002； 55(7)∶889.
15.	Wang HP, Wu MS, Lin CC, et al. Pancreaticobiliary diseases associated with anomalous pancreaticobiliary ductal union [J]. Gastrointest Endosc, 1998； 48(2)∶184.
16.	石景森,王作仁. 胰胆管合流异常与胆道疾病的关系 [J]. 中国实用外科杂志, 1995; 15（10）∶600.
17.	张克俭,段建英,戴希真,等.胰胆管合流异常与胆胰疾病 [J]. 中日友好医院学报, 1995; 9（3）∶161.
18.	张立军,李洁,于则利,等. 胰胆管合流异常合并胆道肿瘤的诊断与治疗 [J]. 中华肝胆外科杂志, 2003 ; 9（10）∶608.
19.	Egami K, Onda M, Uchida E, et al. Clinicopathological studies on association of gallbladder carcinoma and pancreaticobiliary maljunction [J]. Nippon Ika Daigaku Zasshi, 1998； 65(1)∶7.
20.	Shimada K, Yanagisawa J, Nakayama F. Incrensed lysophosphatidylcholine and pancrentic enzyme content in bile of patients with anomalous pancreaticobiliary ductal junction [J]. Hepatology, 1991; 13(3)∶438.
21.	Funabiki T, Sugiue K, Matsubara T, et al. Bile acids and biliary carcinoma in pancreaticobiliary maljunction [J]. Keio J Med, 1991； 40(3)∶118.
22.	Otani K, Shimizu S, Chijiiwa K, et al. Immunohistochemical detection of 8hydroxy2’deoxyguanosine in gallbladder epithelium of patients with pancreaticobiliary maljunction [J]. Eur J Gastroenterol Hepatol, 2001； 13(11)∶1363.
23.	Obara T, Tanno S, Fujii T, et al. Epithelial cell proliferation and gene mutation in the mucosa of gallbladder with pancreaticobiliary maljunction and cancer [J]. J Hepatobiliary Pancreat Surg, 1999; 6(3)∶229.
24.	Hanada K, Itoh M, Fujii K, et al. Pathology and cellular kinetics of gallbladder with an anomalous junction of the pancreaticobiliary duct [J]. Am J Gastroenterol, 1996； 91(5)∶1007.
25.	Kaneko K, Ando H, Ito T, et al. Increased cell proliferation and transforming growth factoralpha (TGF alpha) in the gallbladder epithelium of patients with pancreaticobiliary maljunction [J]. Pathol Int, 1996； 46(4)∶253.
26.	Celoria GC, Rodriguez Otero JC, Proske SA, et al. Papillary hyperplasia and cholesterolosis of the gallbladder [J]. Medicina (B Aires), 1994; 54(1)∶31.
27.	Yang Y, Fujii H, Matsumoto Y, et al. Carcinoma of the gallbladder and anomalous arrangement of the pancreaticobiliary ductal system: cell kinetic studies of gallbladder epithelial cells [J]. J Gastroenterol, 1997； 32(6)∶801.
28.	Tanno S, Obara T, Fujii T, et al. Proliferative potential and Kras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union [J]. Cancer, 1998； 83(2)∶267.
29.	Masuhara S, Kasuya K, Aoki T, et al. Relation between Kras codon 12 mutation and p5 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction [J]. J Hepatobiliary Pancreat Surg, 2000; 7(2)∶198.
30.	Ichikawa Y, Kamiyama M, Sekido H, et al. Telomerase activity and Bcl2 expression in gallbladders of pancreaticobiliary maljunction patients: a preliminary study [J]. J Hepatobiliary Pancreat Surg, 2004; 11(1)∶34.
31.	Asano T, Shoda J, Ueda T, et al. Expressions of cyclooxygenase2 and prostaglandin Ereceptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression [J]. Clin Cancer Res, 2002; 8(4)∶1157.
32.	Hara H, Morita S, Ishibashi T, et al. Surgical treatment for congenital biliary dilatation, with or without intrahepatic bile duct dilatation [J]. Hepatogastroenterology, 2001； 48(39)∶638.
33.	Aoki T, Tsuchida A, Kasuya K, et al. Is preventive resection of the extrahepatic bile duct necessary in cases of pancreaticobiliary maljunction without dilatation of the bile duct? [J]. n J Clin Oncol, 2001； 31(3)∶10734Tsuchida A, Itoi T, Endo M, et al. Pathological features and surgical outcome of pancreaticobiliary maljunction without dilatation of the extrahepatic bile duct [J]. Oncol Rep, 2004； 11(2)∶269.

1. 孟翔凌,何磊,徐阿曼,等. 胰胆管合流异常的临床意义 [J]. 中国普外基础与临床杂志, 2003; 10(5)∶451.
2. Babbitt DP. Congenital choledochal cysts: new etiological concept based on anomalous relationships of the common bile duct and pancreatic bulb [J]. Ann Radiol (Paris), 1969; 12()∶231.
3. Misra SP, Dwivedi M. Pancreaticobiliary ductal union [J]. Gut, 1990； 31(10)∶1144.
4. The Japanese Study Group on Pancreaticobiliary Maljunction（JSPBM）. The committee of JSPBM for diagnostic criteria of pancreaticobiliary maljunction [J]. J Hepatobiliary Pancreat Surg, 1994; 1(3)∶219.
5. Doty J, Hassall E, Fonkalsrud EW. Anomalous drainage of the common bile duct into the fourth portion of the duodenum. Clinical sequelae [J]. Arch Surg, 1985； 120(9)∶1077.
6. Kato O, Hattori K, Suzuki T, et al. Clinical significance of anomalous pancreaticobiliary union [J]. Gastrointest Endosc, 1983； 29(2)∶94.
7. Ono J, Sakoda K, Akita H. Surgical aspect ot cystic dilatation of the bile duct. An anomalous junction of the pancreaticobiliary tract in adults [J]. Ann Surg, 1982； 195(2)∶203.
8. 巫北海.胆胰管十二指肠连接区疾病 [J]. 中国医学计算机成像杂志, 1999; 5(4)∶228.
9. Sasatomi E, Tokunaga O, Miyazaki K. Precancerous conditions of gallbladder carcinoma: overview of histopathologic characteristics and molecular genetic findings [J]. J Hepatobiliary Pancreat Surg, 2000; 7(6)∶556.
10. Tashiro S, Imaizumi T, Ohkawa H, et al. Pancreaticobiliary maljunction: retrospective and nationwide survey in Japan [J]. J Hepatobiliary Pancreat Surg, 2003; 10(5)∶345.
11. Wong KC, Lister J. Human fetal development of the hepatopancreatic duct junction——a possible explanation of congenital dilatation of the biliary tract [J]. J Pediatr Surg, 1981； 16(2)∶139.
12. Matsumoto Y, Fujii H, Itakura J, et al. Pancreaticobiliary maljunction: etiologic concepts based on radiologic aspects [J]. Gastrointest Endosc, 2001； 53(6)∶614.
13. Fujii H, Matsumoto Y, Yamamoto M, et al. Bile flow analysis by hepatobiliary scintigraphy in the terminal bile duct in patients with congenital malformations of the pancreaticobiliary ductal system [J]. Gastroenterol n, 1991； 26(2)∶201.
14. Kim HJ, Kim MH, Lee SK, et al. Normal structure, variations, and anomalies of the pancreaticobiliary ducts of Koreans: a nationwide cooperative prospective study [J]. Gastrointest Endosc, 2002； 55(7)∶889.
15. Wang HP, Wu MS, Lin CC, et al. Pancreaticobiliary diseases associated with anomalous pancreaticobiliary ductal union [J]. Gastrointest Endosc, 1998； 48(2)∶184.
16. 石景森,王作仁. 胰胆管合流异常与胆道疾病的关系 [J]. 中国实用外科杂志, 1995; 15（10）∶600.
17. 张克俭,段建英,戴希真,等.胰胆管合流异常与胆胰疾病 [J]. 中日友好医院学报, 1995; 9（3）∶161.
18. 张立军,李洁,于则利,等. 胰胆管合流异常合并胆道肿瘤的诊断与治疗 [J]. 中华肝胆外科杂志, 2003 ; 9（10）∶608.
19. Egami K, Onda M, Uchida E, et al. Clinicopathological studies on association of gallbladder carcinoma and pancreaticobiliary maljunction [J]. Nippon Ika Daigaku Zasshi, 1998； 65(1)∶7.
20. Shimada K, Yanagisawa J, Nakayama F. Incrensed lysophosphatidylcholine and pancrentic enzyme content in bile of patients with anomalous pancreaticobiliary ductal junction [J]. Hepatology, 1991; 13(3)∶438.
21. Funabiki T, Sugiue K, Matsubara T, et al. Bile acids and biliary carcinoma in pancreaticobiliary maljunction [J]. Keio J Med, 1991； 40(3)∶118.
22. Otani K, Shimizu S, Chijiiwa K, et al. Immunohistochemical detection of 8hydroxy2’deoxyguanosine in gallbladder epithelium of patients with pancreaticobiliary maljunction [J]. Eur J Gastroenterol Hepatol, 2001； 13(11)∶1363.
23. Obara T, Tanno S, Fujii T, et al. Epithelial cell proliferation and gene mutation in the mucosa of gallbladder with pancreaticobiliary maljunction and cancer [J]. J Hepatobiliary Pancreat Surg, 1999; 6(3)∶229.
24. Hanada K, Itoh M, Fujii K, et al. Pathology and cellular kinetics of gallbladder with an anomalous junction of the pancreaticobiliary duct [J]. Am J Gastroenterol, 1996； 91(5)∶1007.
25. Kaneko K, Ando H, Ito T, et al. Increased cell proliferation and transforming growth factoralpha (TGF alpha) in the gallbladder epithelium of patients with pancreaticobiliary maljunction [J]. Pathol Int, 1996； 46(4)∶253.
26. Celoria GC, Rodriguez Otero JC, Proske SA, et al. Papillary hyperplasia and cholesterolosis of the gallbladder [J]. Medicina (B Aires), 1994; 54(1)∶31.
27. Yang Y, Fujii H, Matsumoto Y, et al. Carcinoma of the gallbladder and anomalous arrangement of the pancreaticobiliary ductal system: cell kinetic studies of gallbladder epithelial cells [J]. J Gastroenterol, 1997； 32(6)∶801.
28. Tanno S, Obara T, Fujii T, et al. Proliferative potential and Kras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union [J]. Cancer, 1998； 83(2)∶267.
29. Masuhara S, Kasuya K, Aoki T, et al. Relation between Kras codon 12 mutation and p5 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction [J]. J Hepatobiliary Pancreat Surg, 2000; 7(2)∶198.
30. Ichikawa Y, Kamiyama M, Sekido H, et al. Telomerase activity and Bcl2 expression in gallbladders of pancreaticobiliary maljunction patients: a preliminary study [J]. J Hepatobiliary Pancreat Surg, 2004; 11(1)∶34.
31. Asano T, Shoda J, Ueda T, et al. Expressions of cyclooxygenase2 and prostaglandin Ereceptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression [J]. Clin Cancer Res, 2002; 8(4)∶1157.
32. Hara H, Morita S, Ishibashi T, et al. Surgical treatment for congenital biliary dilatation, with or without intrahepatic bile duct dilatation [J]. Hepatogastroenterology, 2001； 48(39)∶638.
33. Aoki T, Tsuchida A, Kasuya K, et al. Is preventive resection of the extrahepatic bile duct necessary in cases of pancreaticobiliary maljunction without dilatation of the bile duct? [J]. n J Clin Oncol, 2001； 31(3)∶10734Tsuchida A, Itoi T, Endo M, et al. Pathological features and surgical outcome of pancreaticobiliary maljunction without dilatation of the extrahepatic bile duct [J]. Oncol Rep, 2004； 11(2)∶269.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Anomalous Pancreaticobiliary Ductal Junction and Gallbladder Carcinoma

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