Objective To probe the effects of lumbricus on wound healing after hemorroidectomy.
Methods After the solution made from artificial grown lumbricus was sprung to the wound of animal and patient after hemorroidectomy, the wound inflammation, wound healing and changes of laboratory determinations were observed and compared to those of the control group.
Results In animal study, lumbricus could inhibit the growth of staphylococci, bacillus coli and bacillus aeruginosus. The time of wound healing in experimental group was 4 days shorter than that in control group. At 4d and 7 day the numbers of the capillary, blood vessel endodermis and desmohemoblast desmocyte and splitting epithelium of trial group were much more than those of control group. At 4d the trial group′s numbers of splitting mesenchymal cell were much more than that of control group. From 3d on the wound healing and granulation filling of experimental group were much quicker than those of control group. In clinical study, the time of wound healing of trial group ( a mean of 16.5 days) was shorter than that of control group (21.2 days). From 3d on, the epidermis′ growth speed of the trial patients was much quicker than that of control group and was without wound infection and granulation overproliferation.
Conclusion Lumbricus can inhibit wound inflammation response and accelerate wound healing. Lumbricus is inexpensive and easily preserved, and could be used on the wound after hemorroidectomy to accelerate wound healing.
Citation：
LI Dongbing,WANG Pei,ZENG Yaohui,et al.. EXPERIMENTAL AND CLINICAL STUDY ON LUMBRICUS ACCELERATING POSTOPERATIVE WOUND HEALING AFTER HEMORROIDECTOMY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(1): 6-9. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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Bravoor D. PCNA on sell 〔Ｊ〕. Exp Cell Ros, 1986; 37(2)∶287.
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Rodrgo B. The change of DNA 〔Ｊ〕. Cell Biology, 1987; 105(11)∶1549.
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谷廷敏， 牛星焘， 陈东明. 创面愈合过程中EGF基因表达变化的研究 〔Ｊ〕.中国修复重建外科杂志， 1996； 10(3)∶133.
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何红兵， 潘玉先， 王哲生. 内皮细胞生长因子促进创面愈合研究 〔Ｊ〕. 中华试验外科杂志， 1995； 12(5)∶289.
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马育. 外剥内扎加注射治疗环状混合痔202例分析 〔Ｊ〕. 中华医学杂志， 1976； 56(8)∶472.
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- 1. Corno F, Muratore A, Mistrangelo M. Complications of the surgical treatment of hemorrhoids and its therapy 〔Ｊ〕. Ann Ital Chir, 1995; 66(6)∶813.
- 2. 郑富盛. 细胞形态立体计量学 〔Ｍ〕. 第1版. 北京： 北京医科大学协和医科大学联合出版社， 1990∶1～247.
- 3. Dodi G, Pirone E, Cavallari F. Sclerotherapy and elastic ligation of hemorrhoids 〔Ｊ〕. Ann Ital Chir, 1995; 66(6)∶769.
- 4. 张庆荣著. 临床肛门大肠外科学 〔Ｍ〕. 第1版. 天津： 天津科技翻译出版公司， 1991∶141.
- 5. 王正国. 创伤病理学研究进展 〔Ｊ〕.中华创伤杂志， 1997； 13(5)∶266.
- 6. 付小兵编著. 生长因子与创伤修复 〔Ｍ〕. 第1版. 北京： 人民军医出版社， 1991∶145.
- 7. 付小兵， 王亚平. 碱性成纤维细胞生长因子加速猪背部创伤修复的实验研究 〔Ｊ〕. 中华创伤杂志， 1995； 11(3)∶134.
- 8. Orgill D, Demling RH. Current concepts and approaches to wound healing 〔Ｊ〕. Crit Care med, 1988; 45(16)∶899.
- 9. 陆树良. 烧伤创面渗液中二肽肽酶和氨基肽酶对创面愈合的意义 〔Ｊ〕. 国外医学·创伤与外科基本问题分册， 1995； (2)∶111.
- 10. 鲍世铨， 曾耀辉. 蚯蚓在医药保健方面的综合利用研究 〔Ｊ〕. 中国生化药物杂志， 1994； 15(3)∶165.
- 11. 付小兵编著. 生长因子与创伤修复 〔Ｍ〕. 第1版. 北京： 人民军医出版社， 1991∶1～45.
- 12. Bravoor D. PCNA on sell 〔Ｊ〕. Exp Cell Ros, 1986; 37(2)∶287.
- 13. Rodrgo B. The change of DNA 〔Ｊ〕. Cell Biology, 1987; 105(11)∶1549.
- 14. 谷廷敏， 牛星焘， 陈东明. 创面愈合过程中EGF基因表达变化的研究 〔Ｊ〕.中国修复重建外科杂志， 1996； 10(3)∶133.
- 15. 何红兵， 潘玉先， 王哲生. 内皮细胞生长因子促进创面愈合研究 〔Ｊ〕. 中华试验外科杂志， 1995； 12(5)∶289.
- 16. 马育. 外剥内扎加注射治疗环状混合痔202例分析 〔Ｊ〕. 中华医学杂志， 1976； 56(8)∶472.
