EXPERIMENTAL STUDY OF SODIUM HYALURONATE IN PREVENTING POSTOPERATIVE ABDOMINAL ADHESION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Xinping ¹ , JIANG Hongchi. ²

Department of Surgery, Huangpu Central Hospital, Shanghai 200002;

Corresponding author：

Keywords：

Sodium hyaluronate Adhesion of peritoneal cavity Prevention

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Objective To determine the effectiveness of sodium hyaluronate (SHA) in preventing intraperitoneal (IP) adhesion.
Methods Thirty-eight rats were randomly divided into A,B,C groups, normal saline, 6% Dextran-40 or SHA were applied on the present serosal injury respectively, during operation. Biopsy was taken on the 14th postoperative day.
Results There were statistically significant differences in the extent of adhesion among three groups (Ｐ＜0.01). Mild inflammatory changes and less fibrous proliferation were found in group C by microscopy and decreased production of collagen (by fibroblast) and active mesothelial cells proliferation were observed in group C under electron microscope.
Conclusion SHA appeares to reduce the extent of postoperative IP adhesion, which is more satisfactory than Dextran-40.

Citation： YANG Xinping,JIANG Hongchi.. EXPERIMENTAL STUDY OF SODIUM HYALURONATE IN PREVENTING POSTOPERATIVE ABDOMINAL ADHESION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(1): 16-18. doi: Copy

1.	ScottCoombers D, Whawell SA, Vipond MN, et al. Human intraperitoneal fibrinolytic response to surgery 〔Ｊ〕. Br J Surg, 1995; 82(3)∶414.
2.	Trentner KH, Bertram P, Loser S, et al. Prevention and therapy of intraabdominal adhesions. A survey of 1 200 clinics in Germany 〔Ｊ〕. Chirurg, 1995; 66(4)∶398.
3.	Holtz G. Prevention and management of peritoneal adhesions 〔Ｊ〕. Fertil Steril, 1984; 41(4)∶497.
4.	胡建敏，黄绍贤，侯忠民等. 人体脂肪、alpha糜蛋白酶联合腹腔灌注预防粘连的实验及临床研究〔Ｊ〕. 中华实验外科杂志， 1989； 6(3)∶101.
5.	Dillon PW, Keefer K, Blackburn JH, et al. The extracellular matrix of the fetal wound: hyaluronic acid controls lymphocyte adhesion 〔Ｊ〕. J Surg Res, 1994; 57(1)∶170.
6.	Urman B, Gomel V, Jetha N. Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model 〔Ｊ〕. Fertil Steril, 1991; 56(3)∶563.
7.	Yarali H, Zahradka BF, Gomel V. Hyaluronic acid membrane for reducing adhesion formation and reformation in the rat uterine horn 〔Ｊ〕. J Reprod Med, 1994; 39(9)∶667.
8.	Holzman S, Connolly RT, Schwaitzberg SD. Effect of hyaluronic acid solution on healing of bowel anastomoses 〔Ｊ〕. J Invest Surg, 1994; 7(5)∶431.

1. ScottCoombers D, Whawell SA, Vipond MN, et al. Human intraperitoneal fibrinolytic response to surgery 〔Ｊ〕. Br J Surg, 1995; 82(3)∶414.
2. Trentner KH, Bertram P, Loser S, et al. Prevention and therapy of intraabdominal adhesions. A survey of 1 200 clinics in Germany 〔Ｊ〕. Chirurg, 1995; 66(4)∶398.
3. Holtz G. Prevention and management of peritoneal adhesions 〔Ｊ〕. Fertil Steril, 1984; 41(4)∶497.
4. 胡建敏，黄绍贤，侯忠民等. 人体脂肪、alpha糜蛋白酶联合腹腔灌注预防粘连的实验及临床研究〔Ｊ〕. 中华实验外科杂志， 1989； 6(3)∶101.
5. Dillon PW, Keefer K, Blackburn JH, et al. The extracellular matrix of the fetal wound: hyaluronic acid controls lymphocyte adhesion 〔Ｊ〕. J Surg Res, 1994; 57(1)∶170.
6. Urman B, Gomel V, Jetha N. Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model 〔Ｊ〕. Fertil Steril, 1991; 56(3)∶563.
7. Yarali H, Zahradka BF, Gomel V. Hyaluronic acid membrane for reducing adhesion formation and reformation in the rat uterine horn 〔Ｊ〕. J Reprod Med, 1994; 39(9)∶667.
8. Holzman S, Connolly RT, Schwaitzberg SD. Effect of hyaluronic acid solution on healing of bowel anastomoses 〔Ｊ〕. J Invest Surg, 1994; 7(5)∶431.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPERIMENTAL STUDY OF SODIUM HYALURONATE IN PREVENTING POSTOPERATIVE ABDOMINAL ADHESION

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