RELATIONSHIP BETWEEN CD15 ANTIGEN AND ONCOPROTEIN BCL-2 EXPRESSION IN THYROID CANCER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Department of Pathology, The 251st Hospital of PLA, Zhangjiakou 075000;

Corresponding author：

Keywords：

Thyroid cancer CD15 antigen Oncoprotein bcl-2 Immunohistochemistry

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective The expression of CD15 antigen and oncoprotein bcl-2 in thyroid cancer were examined in order to study the correlation between them.
Methods The expression of CD15 and bcl-2 in 50 thyroid cancers, 20 adjacent noncancerous portion, 45 adenoma and 10 normal thyroid tissue were respectively investigated by microwave-LSAB immunohistochemical technique.
Results The positive rate of CD15 and bcl-2 in thyroid cancer was 68.0% and 46.0% respectively, which was significantly higher than that in adenoma or adjacent noncancerous (Ｐ＜0.05). The percentage of CD15 and bcl2 positive expression were found to be significantly correlated with the tumor metastasis (Ｐ＜0.05), but not correlated with histological feature. Expression of CD15 was significantly correlated with bcl-2.
Conclusion Expression of CD15 and bcl-2 can be regarded as a parameter to evaluate tumor metastasis and prognosis of thyroid cancer.

Citation： GU Huaping,SHANG Peizhong,SU Hong,et al.. RELATIONSHIP BETWEEN CD15 ANTIGEN AND ONCOPROTEIN BCL-2 EXPRESSION IN THYROID CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(2): 97-99. doi: Copy

1.	裴雪涛. 细胞粘附分子与肿瘤的发生及转移〔Ｊ〕. 中国病理生理学杂志， 1997； 13(1)∶103.
2.	周同，宋长玲. 细胞粘附分子研究的某些进展〔Ｊ〕. 生命科学， 1994； 6(3)∶27.
3.	Barctton GB, Dicbold J, Christoforis G, et al. Apoptosis and immunohistochemical bcl2 expression in colorectal adenomas and carcinomas 〔Ｊ〕. Cancer, 1996; 77(2)∶225.
4.	陈金联，周同. 选择素与肿瘤转移研究进展〔Ｊ〕. 生命科学， 1996； 8(1)∶31.
5.	Torii A, Nakayama A, Harada A, et al. Expression of the CD15 antigen in hepatocellular carcinoma 〔Ｊ〕. Cancer, 1993; 71(12)∶3864.
6.	Nakagoe T, Fukushima K, Hirota M, et al. Immunohistochemical expression of sialyl lex antigen in relation to survival of patients with colorectal carcinoma 〔Ｊ〕. Cancer, 1993; 72(8)∶2323.
7.	Konety BR, Bullou B, Jaffe R, et al. Expression of SSEA1(Lewis χ) on transitional cell carcinoma of the bladder 〔Ｊ〕. Urol Int, 1997; 58(2)∶69.
8.	Neuhold N, Langle F, Gnant M, et al. Relationship of CD15 immunoreactivity and prognosis in sporadic medullary thyroid carcinoma 〔Ｊ〕. J Cancer Res Clin Oncol, 1992; 118(8)∶629.
9.	朱建伟，陈玉泉，薛化等. 甲状腺肿瘤中原癌基因bcl2的表达及意义〔Ｊ〕. 中华医学杂志， 1996； 76(11)∶829.
10.	李鸣，于茂生，申鹏飞等. 联合应用CHaras, Cmyc反义寡聚脱氧核苷酸对膀胱癌细胞生长增殖的抑制作用〔Ｊ〕. 中华外科杂志， 1996； 34(1)∶7.

1. 裴雪涛. 细胞粘附分子与肿瘤的发生及转移〔Ｊ〕. 中国病理生理学杂志， 1997； 13(1)∶103.
2. 周同，宋长玲. 细胞粘附分子研究的某些进展〔Ｊ〕. 生命科学， 1994； 6(3)∶27.
3. Barctton GB, Dicbold J, Christoforis G, et al. Apoptosis and immunohistochemical bcl2 expression in colorectal adenomas and carcinomas 〔Ｊ〕. Cancer, 1996; 77(2)∶225.
4. 陈金联，周同. 选择素与肿瘤转移研究进展〔Ｊ〕. 生命科学， 1996； 8(1)∶31.
5. Torii A, Nakayama A, Harada A, et al. Expression of the CD15 antigen in hepatocellular carcinoma 〔Ｊ〕. Cancer, 1993; 71(12)∶3864.
6. Nakagoe T, Fukushima K, Hirota M, et al. Immunohistochemical expression of sialyl lex antigen in relation to survival of patients with colorectal carcinoma 〔Ｊ〕. Cancer, 1993; 72(8)∶2323.
7. Konety BR, Bullou B, Jaffe R, et al. Expression of SSEA1(Lewis χ) on transitional cell carcinoma of the bladder 〔Ｊ〕. Urol Int, 1997; 58(2)∶69.
8. Neuhold N, Langle F, Gnant M, et al. Relationship of CD15 immunoreactivity and prognosis in sporadic medullary thyroid carcinoma 〔Ｊ〕. J Cancer Res Clin Oncol, 1992; 118(8)∶629.
9. 朱建伟，陈玉泉，薛化等. 甲状腺肿瘤中原癌基因bcl2的表达及意义〔Ｊ〕. 中华医学杂志， 1996； 76(11)∶829.
10. 李鸣，于茂生，申鹏飞等. 联合应用CHaras, Cmyc反义寡聚脱氧核苷酸对膀胱癌细胞生长增殖的抑制作用〔Ｊ〕. 中华外科杂志， 1996； 34(1)∶7.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

RELATIONSHIP BETWEEN CD15 ANTIGEN AND ONCOPROTEIN BCL-2 EXPRESSION IN THYROID CANCER

Abstract Full text Figures/Tables Video References Cited by

Format

Content