GENE EXPRESSION IN CHOLANGIOCARCINOMA AND ITS CLINICAL SIGNIFICANCE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Zhefu , SHI Guangjun , HU Yili.

Department of Hepatobiliary Surgery, Qingdao Municipal Hospital, Qingdao 266011;

Corresponding author：

Keywords：

Cholangioneoplasm Oncogene Gene expression

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Objective To search for the significant early diagnostic and prognostic indicators in cholangiocarcinoma. Methods Literatures about the variation of various kinds of genes in cholangiocarcinoma and their clinical significances were reviewed.
Results There are several genes mutation, deletion and overexpression in cholangiocarcinoma, K-ras gene was most deeply investigated.
Conclusion K-ras mutation detection may be of help in the early finding and prognosis of cholangiocarcinoma.

Citation： LI Zhefu,SHI Guangjun,HU Yili.. GENE EXPRESSION IN CHOLANGIOCARCINOMA AND ITS CLINICAL SIGNIFICANCE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(2): 131-133. doi: Copy

1.	Lee JC, Lin PW, Lin YJ, et al. Analysis of Kras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffinembedded tissue sections 〔Ｊ〕. J Formos Med ASSOC, 1995; 94(12)∶719.
2.	Kiba T, Tsuda H, Pairojkul C, et al. Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand 〔Ｊ〕. Mol Carcinog, 1993; 8(4)∶312.
3.	王征旭，何振平，房殿春等. 胆管癌ras癌基因、p53抑癌基因突变及表达的研究〔Ｊ〕. 癌症， 1997； 16(1)∶48.
4.	Ohashi K, Tsutsumi M, Nakajima Y, et al. High rats of Kras point mutation in both intra and extrahepatic cholangiocarcinomas 〔Ｊ〕. Jpn J Clin Oncol, 1994; 24(6)∶305.
5.	Tsuda H, Satarug S, Hongsa V, et al. Cholangiocarcinoma in Japanese and Thai patients: difference in etiology and incidence of point mutation of the Kras prooncogene 〔Ｊ〕. Mol Carcinog, 1992; 6(4)∶266.
6.	Tada M, Omata M, Ohto M, et al. Analysis of ras gene mutation in human hepatic malignant tumor by polymerase chain reaction and direct sequencing 〔Ｊ〕. Cancer Res, 1990; 50(4)∶1121.
7.	Levi S, Ispizua U, Gill R, et al. A multiple Kras codon mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique 〔Ｊ〕. Cancer Res, 1991; 51(13)∶3497.
8.	Majima T, Tsujinchi T, Tsutsumi M, et al. Matations of Kras but not p53 gene in biliary duct and pancreatic duct carcinoma induced in hamsters by cholocystoduo denostomy with dissection of the common duct followed by Nnitrosobis (2oxopropyl) amine 〔Ｊ〕. Cancer Lett, 1997; 118(1)∶47.
9.	Tada M, Omata M, Ohto M, et al. High incidence of ras gene mutation in intrahepatic cholangiocarcinoma 〔Ｊ〕. Cancer, 1992; 69(1)∶115.
10.	Imai M, Hoshi T, Ogawa K. Kras codon 12 mutations in biliary tract tumors detected by polymeras chain reaction denaturing gradient gel electrophoresis 〔Ｊ〕. Cancer, 1994; 73(11)∶2727.
11.	Tomono H, Nimura Y, Aono K, et al. Point mutations of the cKiras gene in carcinoma and atypical epithelium associated with congential biliary dilation 〔Ｊ〕. Am J Gastroenterol, 1996; 91(6)∶1211.
12.	Ohita H, Yamaguchi Y, Yamakawa O, et al. Biliary papillomatosis with the point mutation of Kras gene arising in congenital choledochal cyst 〔Ｊ〕. Gastroenterology, 1993; 105(4)∶1209.
13.	Malats N, Porta M, Pinol JL, et al. Kiras mutations as a prognostic factor in extrahepatic bile system cancer. PANKras I project investigators 〔Ｊ〕. J Clin Oncol, 1995; 13(7)∶1679.
14.	Chow NH, Huang SM, Chan SH, et al. Significance of cerb B2 expression in normal and neoplastic epithelium of biliary tract 〔Ｊ〕. Anticancer Res, 1995; 15(3)∶1055.
15.	Collier JD, Guo K, Mathew J, et al. cerb B2 oncogene expression in hepatocellular carcinoma 〔Ｊ〕. J Hepatol, 1992; 14(2)∶377.
16.	Voravud N, Foster CS, Gilbertson JA, et al. Oncogene expression in cholangiocarcinoma and in normal hepatic development 〔Ｊ〕. Hum Pathol, 1989; 20(12)∶1163.
17.	Yoshida S, Todoroki T, Ichikawa Y, et al. Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 gene in biliary tract cancer 〔Ｊ〕. Cancer Res, 1995; 55(10)∶2756.
18.	许春森，殷风峙，陈大良. 胆管癌、胆囊癌cerb B2蛋白表达及其临床意义〔Ｊ〕. 中华实验外科杂志， 1996； 13(4)∶203.
19.	王征旭，何振平，罗永辉等. 胆管癌p53抑癌基因突变及表达的研究〔Ｊ〕. 第三军医大学学报， 1996； 18(1)∶40.
20.	欧阳迪平，杨竹林，李永国. 胆管癌组织中p21、p53、bcl2癌基因蛋白的表达及生物学意义〔Ｊ〕. 中华实验外科杂志， 13(4)∶201.
21.	胡义利，李哲夫，王一等. bax蛋白在胆管癌组织中的表达及意义. 中华肝胆外科杂志， 1999； 5(5)∶344.

1. Lee JC, Lin PW, Lin YJ, et al. Analysis of Kras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffinembedded tissue sections 〔Ｊ〕. J Formos Med ASSOC, 1995; 94(12)∶719.
2. Kiba T, Tsuda H, Pairojkul C, et al. Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand 〔Ｊ〕. Mol Carcinog, 1993; 8(4)∶312.
3. 王征旭，何振平，房殿春等. 胆管癌ras癌基因、p53抑癌基因突变及表达的研究〔Ｊ〕. 癌症， 1997； 16(1)∶48.
4. Ohashi K, Tsutsumi M, Nakajima Y, et al. High rats of Kras point mutation in both intra and extrahepatic cholangiocarcinomas 〔Ｊ〕. Jpn J Clin Oncol, 1994; 24(6)∶305.
5. Tsuda H, Satarug S, Hongsa V, et al. Cholangiocarcinoma in Japanese and Thai patients: difference in etiology and incidence of point mutation of the Kras prooncogene 〔Ｊ〕. Mol Carcinog, 1992; 6(4)∶266.
6. Tada M, Omata M, Ohto M, et al. Analysis of ras gene mutation in human hepatic malignant tumor by polymerase chain reaction and direct sequencing 〔Ｊ〕. Cancer Res, 1990; 50(4)∶1121.
7. Levi S, Ispizua U, Gill R, et al. A multiple Kras codon mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique 〔Ｊ〕. Cancer Res, 1991; 51(13)∶3497.
8. Majima T, Tsujinchi T, Tsutsumi M, et al. Matations of Kras but not p53 gene in biliary duct and pancreatic duct carcinoma induced in hamsters by cholocystoduo denostomy with dissection of the common duct followed by Nnitrosobis (2oxopropyl) amine 〔Ｊ〕. Cancer Lett, 1997; 118(1)∶47.
9. Tada M, Omata M, Ohto M, et al. High incidence of ras gene mutation in intrahepatic cholangiocarcinoma 〔Ｊ〕. Cancer, 1992; 69(1)∶115.
10. Imai M, Hoshi T, Ogawa K. Kras codon 12 mutations in biliary tract tumors detected by polymeras chain reaction denaturing gradient gel electrophoresis 〔Ｊ〕. Cancer, 1994; 73(11)∶2727.
11. Tomono H, Nimura Y, Aono K, et al. Point mutations of the cKiras gene in carcinoma and atypical epithelium associated with congential biliary dilation 〔Ｊ〕. Am J Gastroenterol, 1996; 91(6)∶1211.
12. Ohita H, Yamaguchi Y, Yamakawa O, et al. Biliary papillomatosis with the point mutation of Kras gene arising in congenital choledochal cyst 〔Ｊ〕. Gastroenterology, 1993; 105(4)∶1209.
13. Malats N, Porta M, Pinol JL, et al. Kiras mutations as a prognostic factor in extrahepatic bile system cancer. PANKras I project investigators 〔Ｊ〕. J Clin Oncol, 1995; 13(7)∶1679.
14. Chow NH, Huang SM, Chan SH, et al. Significance of cerb B2 expression in normal and neoplastic epithelium of biliary tract 〔Ｊ〕. Anticancer Res, 1995; 15(3)∶1055.
15. Collier JD, Guo K, Mathew J, et al. cerb B2 oncogene expression in hepatocellular carcinoma 〔Ｊ〕. J Hepatol, 1992; 14(2)∶377.
16. Voravud N, Foster CS, Gilbertson JA, et al. Oncogene expression in cholangiocarcinoma and in normal hepatic development 〔Ｊ〕. Hum Pathol, 1989; 20(12)∶1163.
17. Yoshida S, Todoroki T, Ichikawa Y, et al. Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 gene in biliary tract cancer 〔Ｊ〕. Cancer Res, 1995; 55(10)∶2756.
18. 许春森，殷风峙，陈大良. 胆管癌、胆囊癌cerb B2蛋白表达及其临床意义〔Ｊ〕. 中华实验外科杂志， 1996； 13(4)∶203.
19. 王征旭，何振平，罗永辉等. 胆管癌p53抑癌基因突变及表达的研究〔Ｊ〕. 第三军医大学学报， 1996； 18(1)∶40.
20. 欧阳迪平，杨竹林，李永国. 胆管癌组织中p21、p53、bcl2癌基因蛋白的表达及生物学意义〔Ｊ〕. 中华实验外科杂志， 13(4)∶201.
21. 胡义利，李哲夫，王一等. bax蛋白在胆管癌组织中的表达及意义. 中华肝胆外科杂志， 1999； 5(5)∶344.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

GENE EXPRESSION IN CHOLANGIOCARCINOMA AND ITS CLINICAL SIGNIFICANCE

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