Objective To investigate the relationship among rats′ stress ulcer and gastric acid, prostaglandin (PGs) and adrenocorticotropin (ACTH) and to probe the pathogenesis, prophylaxis and therapy.
Methods Rats′ stress ulcer model was made by cold water soaking and was properly treated with drugs such as hyoscine, dexamethasone, ranitidine and losec. The amount and pH of gastric juice, change of gastric mucosa and PGs and ACTH of blood were determined.
Results After rats were fasted for 24 hours a little gastric juice was aspirated. After cold water soaking of rats gastric juice was increased with the pH decreased, there was gastric mucosal bleeding, blood PGs was decreased and ACTH was increased. These suggest that on stress gastric mucosa bleeding is related with decreased gastric juice pH, decreased PGs and increase ACTH.
Conclusion To control stress ulcer, pH of gastric juice and amount of PGs should be increased. Losec can increase gastric juice pH, so losec is the first choice to control stress ulcer.
Citation：
LI Xun,YU Anguo,DENG Zhenping,et al.. STUDY ON PATHOGENESIS AND TREATMENT OF STRESS ULCER IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(3): 138-140. doi:
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Kivilaakso E. Pathogenetic mechanisms in experimental gastric stress ulceration 〔Ｊ〕. Scand J Gastroenterol, 1985; 20(Supp 110)∶57.
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万军利. 应激性溃疡的形成机制 〔Ｊ〕. 中国病理生理杂志， 1993；9(5)∶664.
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李兆申， 许国铭， 龚彪等. 洛赛克对大鼠胃粘膜血流量的影响及对应激性溃疡的预防实验研究 〔Ｊ〕. 内镜， 1992； 9(1)∶33.
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- 1. 宗育杉， 吴胜群， 李志军等. 大鼠应激性溃疡发病机制及其预防方法的研究〔Ｊ〕. 中国危重病急救医学， 1995； 7(5)∶265.
- 2. 涂易正， 郑扶民. 冷拘束大鼠应激性溃疡的发病机制和药物的预防作用 〔Ｊ〕. 中华实验外科杂志， 1988； 5(3)∶107.
- 3. 应景， 华积德. 应激性溃疡的发病机制及其预防 〔Ｊ〕. 普外临床， 1988； 3(2)∶116.
- 4. Arakawa T, Higuchi K, Fukuda T, et al. Prostaglandins in the stomach: an update 〔Ｊ〕. J Clin Gastroenterol, 1998; 27(Supp 1)∶51.
- 5. Hisato K, Motohatsu F, Yoshitsugu O. Effect of water immersior stress on gastres secretioranc maecsal blood flow in rats 〔Ｊ〕. Gastroenterotogy, 1979; 77(2)∶298.
- 6. Kivilaakso E. Pathogenetic mechanisms in experimental gastric stress ulceration 〔Ｊ〕. Scand J Gastroenterol, 1985; 20(Supp 110)∶57.
- 7. 万军利. 应激性溃疡的形成机制 〔Ｊ〕. 中国病理生理杂志， 1993；9(5)∶664.
- 8. 李兆申， 许国铭， 龚彪等. 洛赛克对大鼠胃粘膜血流量的影响及对应激性溃疡的预防实验研究 〔Ｊ〕. 内镜， 1992； 9(1)∶33.
