THE ROLE OF ENDOTHELIN IN THE PATHOGENIC MECHANISM OF ACUTE PANCREATITIS IN RATS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YUAN Shengguang ¹ , ZHANG Zhaoda ¹ , LIU Xbao ¹ , et al. ²

Department of General Surgery, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;

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Keywords：

Pancreatitis Endothelin

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Objective To study the effects of endothelin (ET) on acute pancreatitis in rats.
Methods The acute edematous pancreatitis (AEP) and hemorrhagic necrotizing pancreatitis (AHNP) model of rats were induced by cerulein and dextran-110 and endothelin-1 was administered on AEP rats via intravenous injection. Serum amylase, plasma ET and 6-Keto-PGF1α, pancreas hostologic observation were determined. Results The serum concentration of amylase increased markedly in AHNP rats, and there was a significant difference between AHNP and AEP (Ｐ＜0.01). A dose of extrinsic ET-1 may induce the conversion of AEP to AHNP in rats. The degree of pancreatic damage correlates positively with the level of the plasma ET.
Conclusion Endothelin might take part in the development of acute pancreatitis, and play a key role in the conversion of AEP to AHNP.

Citation： YUAN Shengguang,ZHANG Zhaoda,LIU Xbao,et al.. THE ROLE OF ENDOTHELIN IN THE PATHOGENIC MECHANISM OF ACUTE PANCREATITIS IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(3): 150-151. doi: Copy

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3.	Hildebxand P, Mrozinski J, Samuel AJR, et al. Pancreatic acini possess endothelin receptors whose internalization is regulated by PLCactivating angents 〔Ｊ〕. Am J Physiol, 1993; 264(27)∶G984.
4.	Takaori K, Inoue K, Kogire M, et al. Effects of endothelin on microcriculation of the pancreas 〔Ｊ〕. Life Sci, 1992; 51(8)∶615.
5.	Kyogoku T, Manabe T, Tobe T, et al. Role of ischemia in acute pancreatitis: hemorrhagic shock converts edematous pancreatitis to hemorrhagic pancreatitis in rats 〔Ｊ〕. Dig Dis Sci, 1992; 37(9)∶1409.
6.	Kourembanas S, Marsden PA, McQuillan LP, et al. Hypoxia induces endothelia gene expression and secretion in cultured human endothelium 〔Ｊ〕. J Clin Invest, 1991; 88(3)∶1054.
7.	Yochisum M, Kurihara H, Sugiyama T, et al. Hemodynamic sheer stress stimulates endothelin production by cultured endothelial cells 〔Ｊ〕. Biochem Biophys Res Commun, 1989; 161(2)∶859.
8.	Gandhi CR, Berkowitz D, Watkins W, et al. Endothelins: biochemistry and pathopysiologic actions 〔Ｊ〕. Anesthesiology, 1994; 80(4)∶892.

1. Klar E, Messerk K, Warshaw AL, et al. Pancreatic ischemia in experimental acute pancreatitis: mechanism, significance and therapy 〔Ｊ〕. Br J Surg, 1990; 77(11)∶1205.
2. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide praduced by vascular endothelial cell 〔Ｊ〕. Nature, 1988; 332(6163)∶411.
3. Hildebxand P, Mrozinski J, Samuel AJR, et al. Pancreatic acini possess endothelin receptors whose internalization is regulated by PLCactivating angents 〔Ｊ〕. Am J Physiol, 1993; 264(27)∶G984.
4. Takaori K, Inoue K, Kogire M, et al. Effects of endothelin on microcriculation of the pancreas 〔Ｊ〕. Life Sci, 1992; 51(8)∶615.
5. Kyogoku T, Manabe T, Tobe T, et al. Role of ischemia in acute pancreatitis: hemorrhagic shock converts edematous pancreatitis to hemorrhagic pancreatitis in rats 〔Ｊ〕. Dig Dis Sci, 1992; 37(9)∶1409.
6. Kourembanas S, Marsden PA, McQuillan LP, et al. Hypoxia induces endothelia gene expression and secretion in cultured human endothelium 〔Ｊ〕. J Clin Invest, 1991; 88(3)∶1054.
7. Yochisum M, Kurihara H, Sugiyama T, et al. Hemodynamic sheer stress stimulates endothelin production by cultured endothelial cells 〔Ｊ〕. Biochem Biophys Res Commun, 1989; 161(2)∶859.
8. Gandhi CR, Berkowitz D, Watkins W, et al. Endothelins: biochemistry and pathopysiologic actions 〔Ｊ〕. Anesthesiology, 1994; 80(4)∶892.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE ROLE OF ENDOTHELIN IN THE PATHOGENIC MECHANISM OF ACUTE PANCREATITIS IN RATS

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