VALUE OF BILE AND SERUM CA19-9 AND CEA IN DIAGNOSING BILIARY TRACT CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Hepatobiliary Surgery, Luoyang Central Hospital, Luoyang 471009;

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Keywords：

Neoplasm of biliary tract Benign biliary lesion Bile Carbohydrate antigen 19-9 Carcinoembryonic antigen

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Objective To evaluate the value of bile and serum CA19-9 in diagnosing biliary tract carcinoma.
Methods Bile and serum CA199 and CEA were determined by radioimmunoassay (RIA).
Results The dividing value of bile CA199 is 12 000 kU/L, and its sensitivity and specificity were 85.71%, 73.91% respectively. The dividing value of bile CEA is 480 μg/L, and its corresponding indexes were 57.14% and 77.17%. The false positive rate of bile CA19-9 and CEA were 26.09% and 22.83%. Serum CA19-9 sensitivity, specificity were 80.00% and 85.11%; the corresponding indexes of serum CEA were 68.57% and 82.97%. Conclusion CA19-9 is an effective tumor marker in diagnosing, deciding whether the tumor has been radically resected and in monitoring its response to the treatment.

Citation： QIN Xinlei,LI Zhiqiang,SHI Jingsen,et al.. VALUE OF BILE AND SERUM CA19-9 AND CEA IN DIAGNOSING BILIARY TRACT CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(3): 161-163. doi: Copy

1.	Hoglund C, Roberts PJ, Kuusela P, et al. Evaluation of CA199 as an serum tumor marker in pancreatic cancer 〔Ｊ〕. Br J Cancer, 1986; 53(2)∶197.
2.	陆雪龙，王百正，时红珍. CA199 RIA的临床观察〔Ｊ〕. 放射免疫学杂志， 1992； 5(4)∶222.
3.	秦兴雷，石景森，王作仁等. 血清和胆汁CA199、CEA联合检测在胆道疾病中的对比研究〔Ｊ〕. 中华实验外科杂志， 1997； (增刊)∶28.
4.	石景森，秦兴雷. CA199在胆囊癌诊断中价值〔Ｊ〕. 普外基础与临床杂志， 1997； 4(2)∶110.
5.	Ohshio G, Manabe T, Watanable Y, et al. Comparative studies of DUPAN2, carcinoembryonic antigen, and CA199 in the serum and bile of patients with pancreatic and biliary tract disease: evaluation of the influence of obstructive jaundice 〔Ｊ〕. Am J Gastroenterol, 1990; 85(10)∶1370.
6.	Albert MB, Steinberg WM, Henry JP. Elevated serum levels of tumor marker CA199 in acute cholangitis 〔Ｊ〕. Dig Dis Sci, 1988; 33(10)∶1223.
7.	Ker CG, Chen JS, Lee KT, et al. Assessment of serum and bile levels of CA199 and CA125 in cholangitis and bile duct carcinoma 〔Ｊ〕. J Gastroenterol Hepatol, 1991; 6(5)∶505.
8.	Matsuda M, Shimizu Y, Chikamatsu E, et al. Role of carcinoembryonic antigen, carbohydrate antigen 199 and cytology of bile in diagnosis of biliary and pancreatic cancer 〔Ｊ〕. Nippon Geka Gakkai Zasshi, 1991; 92(6)∶716.

1. Hoglund C, Roberts PJ, Kuusela P, et al. Evaluation of CA199 as an serum tumor marker in pancreatic cancer 〔Ｊ〕. Br J Cancer, 1986; 53(2)∶197.
2. 陆雪龙，王百正，时红珍. CA199 RIA的临床观察〔Ｊ〕. 放射免疫学杂志， 1992； 5(4)∶222.
3. 秦兴雷，石景森，王作仁等. 血清和胆汁CA199、CEA联合检测在胆道疾病中的对比研究〔Ｊ〕. 中华实验外科杂志， 1997； (增刊)∶28.
4. 石景森，秦兴雷. CA199在胆囊癌诊断中价值〔Ｊ〕. 普外基础与临床杂志， 1997； 4(2)∶110.
5. Ohshio G, Manabe T, Watanable Y, et al. Comparative studies of DUPAN2, carcinoembryonic antigen, and CA199 in the serum and bile of patients with pancreatic and biliary tract disease: evaluation of the influence of obstructive jaundice 〔Ｊ〕. Am J Gastroenterol, 1990; 85(10)∶1370.
6. Albert MB, Steinberg WM, Henry JP. Elevated serum levels of tumor marker CA199 in acute cholangitis 〔Ｊ〕. Dig Dis Sci, 1988; 33(10)∶1223.
7. Ker CG, Chen JS, Lee KT, et al. Assessment of serum and bile levels of CA199 and CA125 in cholangitis and bile duct carcinoma 〔Ｊ〕. J Gastroenterol Hepatol, 1991; 6(5)∶505.
8. Matsuda M, Shimizu Y, Chikamatsu E, et al. Role of carcinoembryonic antigen, carbohydrate antigen 199 and cytology of bile in diagnosis of biliary and pancreatic cancer 〔Ｊ〕. Nippon Geka Gakkai Zasshi, 1991; 92(6)∶716.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

VALUE OF BILE AND SERUM CA19-9 AND CEA IN DIAGNOSING BILIARY TRACT CARCINOMA

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