EXPRESSION AND ROLE OF METALLOPROTEINASES IN BREAST CANCER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xiaodong

Department of General Surgery, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;

Corresponding author：

Keywords：

Breast cancer Metalloproteinases

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Abstract Full text Figures/Tables Video References Cited by

Objective To study the relationship between metalloproteinases (MMPs) and breast cancer.
Methods The literature in recent years on the relationship between the expression of MMPs and breast cancer was reviewed.
Results The balance between MMPs and tissue inhibitors of metalloproteinases (TIMPs) is keeping normally kept in human body. Many of the studies showed that the expression of MMPs is increased in breast cancer. Conclusion The growth, invasion and metastasis of breast cancer is closely related with the increased expression of MMPs. This suggests that MMPs is a valuable prognostic marker and TIMPs would be a novel drug against cancer.

Citation： WANG Xiaodong,YANG Jinqiao.. EXPRESSION AND ROLE OF METALLOPROTEINASES IN BREAST CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(5): 341-343. doi: Copy

1.	Benund C, Robert B, Erik W, et al. Roles of matrix metalloproteinases in mammary gland development and cancer 〔Ｊ〕. Breast Cancer Treast, 1998; 50(2)∶97.
2.	Benund C, Robert B, Erik W, et al. Roles of matrix metalloproteinases in mammary gland development and cancer 〔Ｊ〕. Breast Cancer Treast, 1998; 50(2)∶97.
3.	Pendas AM, Knauper V, Puente XS, et al. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution 〔Ｊ〕. J Biol Chem, 1997; 272(7)∶4281.
4.	Pendas AM, Knauper V, Puente XS, et al. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution 〔Ｊ〕. J Biol Chem, 1997; 272(7)∶4281.
5.	Dia S, Boyd R, Ballkwill F, et al. IL12 regulate VEGF and MMPs in a murine breast cancer model 〔Ｊ〕. Int J Cancer, 1998; 78(3)∶361.
6.	Dia S, Boyd R, Ballkwill F, et al. IL12 regulate VEGF and MMPs in a murine breast cancer model 〔Ｊ〕. Int J Cancer, 1998; 78(3)∶361.
7.	Gum R, Lengyel E, Juarez J, et al. Stimulation of 92kDa glatinase B promotor activity by ras is mitogenactivated protein kinase 1independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP1 sequences 〔Ｊ〕. J Biol Chem, 1996; 271(18)∶10672.
8.	Gum R, Lengyel E, Juarez J, et al. Stimulation of 92kDa glatinase B promotor activity by ras is mitogenactivated protein kinase 1independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP1 sequences 〔Ｊ〕. J Biol Chem, 1996; 271(18)∶10672.
9.	Ishigaki S, Toi M, Ueno T, et al. Significance of menbrane type 1 matrix metalloproteinase expression in breast cancer 〔Ｊ〕. Jpn J Cancer Res, 1999; 90(5)∶516.
10.	Ishigaki S, Toi M, Ueno T, et al. Significance of menbrane type 1 matrix metalloproteinase expression in breast cancer 〔Ｊ〕. Jpn J Cancer Res, 1999; 90(5)∶516.
11.	Ioachim EE, Athanassiadon ES, Kaminas S, et al. Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type Ⅳ, collagen, laminin, fibronectin, EGFR, cerb B2 oncoprotein, p53, steroid receptors status and proliferative indices 〔Ｊ〕. Anti Cancer Res, 1998; 18(3A)∶1665.
12.	Ioachim EE, Athanassiadon ES, Kaminas S, et al. Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type Ⅳ, collagen, laminin, fibronectin, EGFR, cerb B2 oncoprotein, p53, steroid receptors status and proliferative indices 〔Ｊ〕. Anti Cancer Res, 1998; 18(3A)∶1665.
13.	Reddy KB, Krueger JS, Kondapaka SB, et al. Mitogenactivated protein kinase (MAPK) regulates the expression of progelatinase (MMP9) in breast epithelial cells 〔Ｊ〕. Int J Cancer, 1999; 82(2)∶268.
14.	Reddy KB, Krueger JS, Kondapaka SB, et al. Mitogenactivated protein kinase (MAPK) regulates the expression of progelatinase (MMP9) in breast epithelial cells 〔Ｊ〕. Int J Cancer, 1999; 82(2)∶268.
15.	Poulsom R, Hanby AM, Pignatelli M, et al. Expression of gelatinase A and TIMP2 mRNAs in desmoplastic fibrolasts in both mammary carcinomas and basal cell carcinomas of the skin 〔Ｊ〕. J Clin Pathol, 1993; 46(5)∶429.
16.	Poulsom R, Hanby AM, Pignatelli M, et al. Expression of gelatinase A and TIMP2 mRNAs in desmoplastic fibrolasts in both mammary carcinomas and basal cell carcinomas of the skin 〔Ｊ〕. J Clin Pathol, 1993; 46(5)∶429.
17.	Kossakowska AE, Huchcroft SA, Urbanski SJ, et al. Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, pulmonary carcinomas and malignant nonHodgkin’s lymphomas in humansz 〔Ｊ〕. Br J Cancer, 1996; 73(11)∶1401.
18.	Kossakowska AE, Huchcroft SA, Urbanski SJ, et al. Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, pulmonary carcinomas and malignant nonHodgkin’s lymphomas in humansz 〔Ｊ〕. Br J Cancer, 1996; 73(11)∶1401.
19.	Balbin M, Pendas AM, Uria JA, et al. Expression and regulation of collagenase3 (MMP13) in human malignant tumors 〔Ｊ〕. APMIS, 1999; 107(1)∶45.
20.	Balbin M, Pendas AM, Uria JA, et al. Expression and regulation of collagenase3 (MMP13) in human malignant tumors 〔Ｊ〕. APMIS, 1999; 107(1)∶45.
21.	Iwata H, Kobayashi S, Iwase H, et al. Production of matrix metalloproteinase and tissue nihibitors of metalloproteinases in human breast carcinomas 〔Ｊ〕. Jpn J Cancer Res, 1996; 87(6)∶602.
22.	Iwata H, Kobayashi S, Iwase H, et al. Production of matrix metalloproteinase and tissue nihibitors of metalloproteinases in human breast carcinomas 〔Ｊ〕. Jpn J Cancer Res, 1996; 87(6)∶602.
23.	TalvensaariMattila A, Pdakko P, Hoyhtya M, et al. Matrix metalloproteinase2 immunoreactive protein: a marker of aggressive in breast carcinoma 〔Ｊ〕. Cancer, 1998; 83(6)∶1153.
24.	TalvensaariMattila A, Pdakko P, Hoyhtya M, et al. Matrix metalloproteinase2 immunoreactive protein: a marker of aggressive in breast carcinoma 〔Ｊ〕. Cancer, 1998; 83(6)∶1153.
25.	Polette M, Gilles C, Marchand V, et al. Induction of membranetype matrix metalloproteinase 1 (MT1MMP) expression in human fibroblasts by breast adenocarcinoma cells 〔Ｊ〕. Clin Exp M, 1997; 15(2)∶157.
26.	Polette M, Gilles C, Marchand V, et al. Induction of membranetype matrix metalloproteinase 1 (MT1MMP) expression in human fibroblasts by breast adenocarcinoma cells 〔Ｊ〕. Clin Exp M, 1997; 15(2)∶157.
27.	Nakopoulou L, Giannopoulou I, Gakioloulou H, et al. Matrix metalloproteinase1 and 3 in breast cancer: correlation with progesterone receptors and other clinicopathologic features 〔Ｊ〕. Hum Pathol, 1999; 30(4)∶436.
28.	Nakopoulou L, Giannopoulou I, Gakioloulou H, et al. Matrix metalloproteinase1 and 3 in breast cancer: correlation with progesterone receptors and other clinicopathologic features 〔Ｊ〕. Hum Pathol, 1999; 30(4)∶436.
29.	Giunciuglio D, Dulty M, Fassina G, et al. Invasive phenotype of MCF10A cells overexpressing cHaras and cerb B2 oncogenes 〔Ｊ〕. Int J Cancer, 1995; 63(6)∶815.
30.	Giunciuglio D, Dulty M, Fassina G, et al. Invasive phenotype of MCF10A cells overexpressing cHaras and cerb B2 oncogenes 〔Ｊ〕. Int J Cancer, 1995; 63(6)∶815.
31.	Orucevic A, Bechberger J, Green AM, et al. Matrixoxide production by murine mammary adenocarcinoma cells promtes tumorcell invasiveness 〔Ｊ〕. Int J Cancer, 1999; 81(6)∶889.
32.	Orucevic A, Bechberger J, Green AM, et al. Matrixoxide production by murine mammary adenocarcinoma cells promtes tumorcell invasiveness 〔Ｊ〕. Int J Cancer, 1999; 81(6)∶889.
33.	Taipale J, KeskiOja JG. Growth factors in the extracellular matrix 〔Ｊ〕. FASEB J, 1997; 11(1)∶51.
34.	Taipale J, KeskiOja JG. Growth factors in the extracellular matrix 〔Ｊ〕. FASEB J, 1997; 11(1)∶51.
35.	Whitelock JM, Murdoch AD, Iozzo RV, et al. The degradation of human endothelial cellderived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases 〔Ｊ〕. J Biol Chem, 1996; 271(17)∶10079.
36.	Whitelock JM, Murdoch AD, Iozzo RV, et al. The degradation of human endothelial cellderived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases 〔Ｊ〕. J Biol Chem, 1996; 271(17)∶10079.
37.	Kurizaki T, Toi M, Tominaga T, et al. Relationship between matrix metalloproteinase expression and tumor angiogensis in human breast carcinomas 〔Ｊ〕. Oncol Rep, 1998; 5(3)∶673.
38.	Kurizaki T, Toi M, Tominaga T, et al. Relationship between matrix metalloproteinase expression and tumor angiogensis in human breast carcinomas 〔Ｊ〕. Oncol Rep, 1998; 5(3)∶673.
39.	Shalinsky DR, Brekken J, Zou H, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials 〔Ｊ〕. Ann NY Acad Sci, 1999; 878(1)∶236.
40.	Shalinsky DR, Brekken J, Zou H, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials 〔Ｊ〕. Ann NY Acad Sci, 1999; 878(1)∶236.
41.	Shao ZM, Wu J, Shen ZZ, et al. Genistein exerts muptiple suppressive effets on human breast carcinoma cells 〔Ｊ〕. Cancer Res, 1998; 58(21)∶4851.
42.	Shao ZM, Wu J, Shen ZZ, et al. Genistein exerts muptiple suppressive effets on human breast carcinoma cells 〔Ｊ〕. Cancer Res, 1998; 58(21)∶4851.
43.	Sledge Jr GW, Qulali M, Goulet R, et al. Effect of matrix metalloproteinase inhibitor batimasat on breast cancer regrowth and metastasis in athymic mice 〔Ｊ〕. J Natl Cancer Inst, 1995; 87(7)∶1546.
44.	Sledge Jr GW, Qulali M, Goulet R, et al. Effect of matrix metalloproteinase inhibitor batimasat on breast cancer regrowth and metastasis in athymic mice 〔Ｊ〕. J Natl Cancer Inst, 1995; 87(7)∶1546.
45.	Chenard MP, Lutz Y, MechineNeuville A, et al. Presence of high levels of MT1MMP protein in fibroblastic cells of human invastive carcinomas 〔Ｊ〕. Int J Cancer, 1999; 82(2)∶208.
46.	Chenard MP, Lutz Y, MechineNeuville A, et al. Presence of high levels of MT1MMP protein in fibroblastic cells of human invastive carcinomas 〔Ｊ〕. Int J Cancer, 1999; 82(2)∶208.
47.	Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expression on the surface of invasive tumor cells 〔Ｊ〕. Nature, 1994; 370(7)∶61.
48.	Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expression on the surface of invasive tumor cells 〔Ｊ〕. Nature, 1994; 370(7)∶61.
49.	Belloc C, Lu H, Soria C, et al. The effect of platelets on invasiveness and protease production of human mammary tumor cells 〔Ｊ〕. Int J Cancer, 1995; 60(3)∶413.
50.	Yoneda T, Sasaki A, Dunstan C, et al. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bosphosphonats ibandrenate and tissue inhibitor of the matrix metalloproteinase2 〔Ｊ〕. J Clin Invest, 1997; 99(10)∶2509C, Lu H, Soria C, et al. The effect of platelets on invasiveness and protease production of human mammary tumor cells 〔Ｊ〕. Int J Cancer, 1995; 60(3)∶413.
51.	Yoneda T, Sasaki A, Dunstan C, et al. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bosphosphonats ibandrenate and tissue inhibitor of the matrix metalloproteinase2 〔Ｊ〕. J Clin Invest, 1997; 99(10)∶2509.

1. Benund C, Robert B, Erik W, et al. Roles of matrix metalloproteinases in mammary gland development and cancer 〔Ｊ〕. Breast Cancer Treast, 1998; 50(2)∶97.
2. Benund C, Robert B, Erik W, et al. Roles of matrix metalloproteinases in mammary gland development and cancer 〔Ｊ〕. Breast Cancer Treast, 1998; 50(2)∶97.
3. Pendas AM, Knauper V, Puente XS, et al. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution 〔Ｊ〕. J Biol Chem, 1997; 272(7)∶4281.
4. Pendas AM, Knauper V, Puente XS, et al. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution 〔Ｊ〕. J Biol Chem, 1997; 272(7)∶4281.
5. Dia S, Boyd R, Ballkwill F, et al. IL12 regulate VEGF and MMPs in a murine breast cancer model 〔Ｊ〕. Int J Cancer, 1998; 78(3)∶361.
6. Dia S, Boyd R, Ballkwill F, et al. IL12 regulate VEGF and MMPs in a murine breast cancer model 〔Ｊ〕. Int J Cancer, 1998; 78(3)∶361.
7. Gum R, Lengyel E, Juarez J, et al. Stimulation of 92kDa glatinase B promotor activity by ras is mitogenactivated protein kinase 1independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP1 sequences 〔Ｊ〕. J Biol Chem, 1996; 271(18)∶10672.
8. Gum R, Lengyel E, Juarez J, et al. Stimulation of 92kDa glatinase B promotor activity by ras is mitogenactivated protein kinase 1independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP1 sequences 〔Ｊ〕. J Biol Chem, 1996; 271(18)∶10672.
9. Ishigaki S, Toi M, Ueno T, et al. Significance of menbrane type 1 matrix metalloproteinase expression in breast cancer 〔Ｊ〕. Jpn J Cancer Res, 1999; 90(5)∶516.
10. Ishigaki S, Toi M, Ueno T, et al. Significance of menbrane type 1 matrix metalloproteinase expression in breast cancer 〔Ｊ〕. Jpn J Cancer Res, 1999; 90(5)∶516.
11. Ioachim EE, Athanassiadon ES, Kaminas S, et al. Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type Ⅳ, collagen, laminin, fibronectin, EGFR, cerb B2 oncoprotein, p53, steroid receptors status and proliferative indices 〔Ｊ〕. Anti Cancer Res, 1998; 18(3A)∶1665.
12. Ioachim EE, Athanassiadon ES, Kaminas S, et al. Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type Ⅳ, collagen, laminin, fibronectin, EGFR, cerb B2 oncoprotein, p53, steroid receptors status and proliferative indices 〔Ｊ〕. Anti Cancer Res, 1998; 18(3A)∶1665.
13. Reddy KB, Krueger JS, Kondapaka SB, et al. Mitogenactivated protein kinase (MAPK) regulates the expression of progelatinase (MMP9) in breast epithelial cells 〔Ｊ〕. Int J Cancer, 1999; 82(2)∶268.
14. Reddy KB, Krueger JS, Kondapaka SB, et al. Mitogenactivated protein kinase (MAPK) regulates the expression of progelatinase (MMP9) in breast epithelial cells 〔Ｊ〕. Int J Cancer, 1999; 82(2)∶268.
15. Poulsom R, Hanby AM, Pignatelli M, et al. Expression of gelatinase A and TIMP2 mRNAs in desmoplastic fibrolasts in both mammary carcinomas and basal cell carcinomas of the skin 〔Ｊ〕. J Clin Pathol, 1993; 46(5)∶429.
16. Poulsom R, Hanby AM, Pignatelli M, et al. Expression of gelatinase A and TIMP2 mRNAs in desmoplastic fibrolasts in both mammary carcinomas and basal cell carcinomas of the skin 〔Ｊ〕. J Clin Pathol, 1993; 46(5)∶429.
17. Kossakowska AE, Huchcroft SA, Urbanski SJ, et al. Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, pulmonary carcinomas and malignant nonHodgkin’s lymphomas in humansz 〔Ｊ〕. Br J Cancer, 1996; 73(11)∶1401.
18. Kossakowska AE, Huchcroft SA, Urbanski SJ, et al. Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, pulmonary carcinomas and malignant nonHodgkin’s lymphomas in humansz 〔Ｊ〕. Br J Cancer, 1996; 73(11)∶1401.
19. Balbin M, Pendas AM, Uria JA, et al. Expression and regulation of collagenase3 (MMP13) in human malignant tumors 〔Ｊ〕. APMIS, 1999; 107(1)∶45.
20. Balbin M, Pendas AM, Uria JA, et al. Expression and regulation of collagenase3 (MMP13) in human malignant tumors 〔Ｊ〕. APMIS, 1999; 107(1)∶45.
21. Iwata H, Kobayashi S, Iwase H, et al. Production of matrix metalloproteinase and tissue nihibitors of metalloproteinases in human breast carcinomas 〔Ｊ〕. Jpn J Cancer Res, 1996; 87(6)∶602.
22. Iwata H, Kobayashi S, Iwase H, et al. Production of matrix metalloproteinase and tissue nihibitors of metalloproteinases in human breast carcinomas 〔Ｊ〕. Jpn J Cancer Res, 1996; 87(6)∶602.
23. TalvensaariMattila A, Pdakko P, Hoyhtya M, et al. Matrix metalloproteinase2 immunoreactive protein: a marker of aggressive in breast carcinoma 〔Ｊ〕. Cancer, 1998; 83(6)∶1153.
24. TalvensaariMattila A, Pdakko P, Hoyhtya M, et al. Matrix metalloproteinase2 immunoreactive protein: a marker of aggressive in breast carcinoma 〔Ｊ〕. Cancer, 1998; 83(6)∶1153.
25. Polette M, Gilles C, Marchand V, et al. Induction of membranetype matrix metalloproteinase 1 (MT1MMP) expression in human fibroblasts by breast adenocarcinoma cells 〔Ｊ〕. Clin Exp M, 1997; 15(2)∶157.
26. Polette M, Gilles C, Marchand V, et al. Induction of membranetype matrix metalloproteinase 1 (MT1MMP) expression in human fibroblasts by breast adenocarcinoma cells 〔Ｊ〕. Clin Exp M, 1997; 15(2)∶157.
27. Nakopoulou L, Giannopoulou I, Gakioloulou H, et al. Matrix metalloproteinase1 and 3 in breast cancer: correlation with progesterone receptors and other clinicopathologic features 〔Ｊ〕. Hum Pathol, 1999; 30(4)∶436.
28. Nakopoulou L, Giannopoulou I, Gakioloulou H, et al. Matrix metalloproteinase1 and 3 in breast cancer: correlation with progesterone receptors and other clinicopathologic features 〔Ｊ〕. Hum Pathol, 1999; 30(4)∶436.
29. Giunciuglio D, Dulty M, Fassina G, et al. Invasive phenotype of MCF10A cells overexpressing cHaras and cerb B2 oncogenes 〔Ｊ〕. Int J Cancer, 1995; 63(6)∶815.
30. Giunciuglio D, Dulty M, Fassina G, et al. Invasive phenotype of MCF10A cells overexpressing cHaras and cerb B2 oncogenes 〔Ｊ〕. Int J Cancer, 1995; 63(6)∶815.
31. Orucevic A, Bechberger J, Green AM, et al. Matrixoxide production by murine mammary adenocarcinoma cells promtes tumorcell invasiveness 〔Ｊ〕. Int J Cancer, 1999; 81(6)∶889.
32. Orucevic A, Bechberger J, Green AM, et al. Matrixoxide production by murine mammary adenocarcinoma cells promtes tumorcell invasiveness 〔Ｊ〕. Int J Cancer, 1999; 81(6)∶889.
33. Taipale J, KeskiOja JG. Growth factors in the extracellular matrix 〔Ｊ〕. FASEB J, 1997; 11(1)∶51.
34. Taipale J, KeskiOja JG. Growth factors in the extracellular matrix 〔Ｊ〕. FASEB J, 1997; 11(1)∶51.
35. Whitelock JM, Murdoch AD, Iozzo RV, et al. The degradation of human endothelial cellderived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases 〔Ｊ〕. J Biol Chem, 1996; 271(17)∶10079.
36. Whitelock JM, Murdoch AD, Iozzo RV, et al. The degradation of human endothelial cellderived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases 〔Ｊ〕. J Biol Chem, 1996; 271(17)∶10079.
37. Kurizaki T, Toi M, Tominaga T, et al. Relationship between matrix metalloproteinase expression and tumor angiogensis in human breast carcinomas 〔Ｊ〕. Oncol Rep, 1998; 5(3)∶673.
38. Kurizaki T, Toi M, Tominaga T, et al. Relationship between matrix metalloproteinase expression and tumor angiogensis in human breast carcinomas 〔Ｊ〕. Oncol Rep, 1998; 5(3)∶673.
39. Shalinsky DR, Brekken J, Zou H, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials 〔Ｊ〕. Ann NY Acad Sci, 1999; 878(1)∶236.
40. Shalinsky DR, Brekken J, Zou H, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials 〔Ｊ〕. Ann NY Acad Sci, 1999; 878(1)∶236.
41. Shao ZM, Wu J, Shen ZZ, et al. Genistein exerts muptiple suppressive effets on human breast carcinoma cells 〔Ｊ〕. Cancer Res, 1998; 58(21)∶4851.
42. Shao ZM, Wu J, Shen ZZ, et al. Genistein exerts muptiple suppressive effets on human breast carcinoma cells 〔Ｊ〕. Cancer Res, 1998; 58(21)∶4851.
43. Sledge Jr GW, Qulali M, Goulet R, et al. Effect of matrix metalloproteinase inhibitor batimasat on breast cancer regrowth and metastasis in athymic mice 〔Ｊ〕. J Natl Cancer Inst, 1995; 87(7)∶1546.
44. Sledge Jr GW, Qulali M, Goulet R, et al. Effect of matrix metalloproteinase inhibitor batimasat on breast cancer regrowth and metastasis in athymic mice 〔Ｊ〕. J Natl Cancer Inst, 1995; 87(7)∶1546.
45. Chenard MP, Lutz Y, MechineNeuville A, et al. Presence of high levels of MT1MMP protein in fibroblastic cells of human invastive carcinomas 〔Ｊ〕. Int J Cancer, 1999; 82(2)∶208.
46. Chenard MP, Lutz Y, MechineNeuville A, et al. Presence of high levels of MT1MMP protein in fibroblastic cells of human invastive carcinomas 〔Ｊ〕. Int J Cancer, 1999; 82(2)∶208.
47. Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expression on the surface of invasive tumor cells 〔Ｊ〕. Nature, 1994; 370(7)∶61.
48. Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expression on the surface of invasive tumor cells 〔Ｊ〕. Nature, 1994; 370(7)∶61.
49. Belloc C, Lu H, Soria C, et al. The effect of platelets on invasiveness and protease production of human mammary tumor cells 〔Ｊ〕. Int J Cancer, 1995; 60(3)∶413.
50. Yoneda T, Sasaki A, Dunstan C, et al. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bosphosphonats ibandrenate and tissue inhibitor of the matrix metalloproteinase2 〔Ｊ〕. J Clin Invest, 1997; 99(10)∶2509C, Lu H, Soria C, et al. The effect of platelets on invasiveness and protease production of human mammary tumor cells 〔Ｊ〕. Int J Cancer, 1995; 60(3)∶413.
51. Yoneda T, Sasaki A, Dunstan C, et al. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bosphosphonats ibandrenate and tissue inhibitor of the matrix metalloproteinase2 〔Ｊ〕. J Clin Invest, 1997; 99(10)∶2509.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPRESSION AND ROLE OF METALLOPROTEINASES IN BREAST CANCER

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