THE ADVANCE IN RESEARCHING INTO HEPATOCYTE GROWTH FACTOR AND RECEPTOR c-met IN BREAST CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YIN Jiajun ¹

Department of General Surgery, The Fourth Affiliated Hospital, Dalian University of Medical Sciences, Dalian 116001;

Corresponding author：

Keywords：

Hepatocyte growth factor Prooncogene protein c-met Breast carcinoma

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Objective To study the effects of hepatocyte growth factor (HGF) and receptor c-met on the development of primary breast carcinoma, and the relationship between it and prognosis.
Methods The study of HGF and c-met related to breast carcinoma was reviewed by history document and experimental study in recent years.
Results HGF is a growth factor which has mitogenic, migrating, invasive and angiogenic activities in breast carcinoma cells. The carcinogenic mechanism of breast carcinoma was more clear with the discovery of the relationship between HGF and its receptor c-met.
Conclusion The HGF/c-met plays an important role in the generation and progress of breast carcinoma. Studying the effects of HGF/cmet on breast carcinoma is significant in guiding clinical treatment.

Citation： YIN Jiajun,SONG Yan.. THE ADVANCE IN RESEARCHING INTO HEPATOCYTE GROWTH FACTOR AND RECEPTOR c-met IN BREAST CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(5): 347-349. doi: Copy

1.	Di Renzo MF, Narsimhan RP, Olivero M, et al. Expression of the MET/HGF receptor in normal and neoplastic human tissues 〔Ｊ〕. Oncogene, 1997; 6(11)∶2003.
2.	Matsumoto K, Nakamura T. Hepatocyte growth factor(HGF) as a tissue organizer for organogenesis and regeneration 〔Ｊ〕. Biochem Biophys Res Commun, 1997; 239(3)∶639.
3.	Weidner KM, Behrens J, Vandekerckhove J, et al. Scatter factor: molecular characteristics and effect on invasiveness of epithelial cells 〔Ｊ〕. J Cell Biol, 1990; 111(5)∶2097.
4.	Rosen EM, Knesel J, Goldberg ID, et al. Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor 〔Ｊ〕. Int J Cancer, 1994; 57(5)∶706.
5.	Yamashita J, Ogawa M, Beppu T. Immunoreactive hepatocyte growth factor is present in tissue extracts from human breast cancer but not in conditioned medium of human breast cancer cell lines 〔Ｊ〕. Res Commun Chem Pathol Pharmacol, 1993; 82(2)∶249.
6.	Rubin JS,Chan AM, Bottaro DP, et al. A broodspectrum human lung fibroblastderived mitogen is a variant of hepatocyte growth factor 〔Ｊ〕. Proc Natl Acad Sci USA, 1991; 88(2)∶415.
7.	Rosenthal EL, Johnson TM, Allen ED, et al. Role of the plasminogen activator matrix metalloproteinase systems in epidermal growth factorand scatter factorstimulated invasion of carcinoma cells 〔Ｊ〕. Cancer Res, 1998; 58(22)∶5221.
8.	Bostick PJ, Huynh KT, Sarantou T, et al. Detection of metastases in sentinel lymph nodes of breast cancer patients by multiplemarker RTPCR 〔Ｊ〕. Int J Cancer, 1998; 79(6)∶645.
9.	Yamashita J, Ogawa M, Yamashita S, et al. Immunoreactive Hepatocyte Growth Factor is a strong and independent predictor of recurrence and survival in human breast cancer 〔Ｊ〕. Cancer Res, 1994; 54(7)∶1630.
10.	Tsarfaty I, Alvord WG, Resau JH, et al. Alteration of Met Protooncogene product expression and prognosis in breast carcinomas 〔Ｊ〕. Anal Quant Cytol Histol, 1999; 21(5)∶397.
11.	Seslar SP, Nakamura T, Stephen WB. Regulation of fibroblast hepatocyte growth factor/scatter factor expression by human breast carcinoma cell lines and peptide growth factors 〔Ｊ〕. Cancer Res, 1993; 53(6)∶1233.
12.	Nakamura T, Matsumoto K, Kiritoshi A, et al. Induction of hepatocyte growth factor in fibroblasts by tumorderived factors affects invasive growth of tumor cells: in vitro analysis of tumorstromal interactions 〔Ｊ〕. Cancer Res, 1997; 57(15)∶3305.
13.	Matsumoto TN, Matsumoto K, Nakamura T. Prostaglandin production in mouse mammary tumor cells confers in vasive growth potential by inducing hepatocyte growth factor in stromal fibroblasts 〔Ｊ〕. Br J Cancer, 1999; 81(2)∶194.
14.	Kuniyasu H, Yasui W, Kitadai Y, et al. Frequent amplification of the cmet gene in scirrhous type stomach cancer 〔Ｊ〕. Biochem Biophys Res Commun, 1992; 189(1)∶227.
15.	Liu C, Park M, Tsao MS. Overexpression of cmet protooncogene but not epidermal growth factor receptor or cerb B2 in primary human colorectal carcinomas 〔Ｊ〕. Oncogene, 1992; 7(1)∶181.
16.	Schulte KM, Antoch G, Ellrichmann M, et al. Regulation of the HGFreceptor cmet in the thyroid gland 〔Ｊ〕. Exp Clin Endocrinol Diabetes, 1998; 106(4)∶310.
17.	Di Renzo MF, Olivero M, Katsaros D, et al. Overexpression of the MET/HGF receptor in ovarian cancer 〔Ｊ〕. Int J Cancer, 1994; 58(5)∶658.
18.	Natali PG, Prat M, Nicotra MR, et al. Overexpression of the met/HGF receptor in renal cell carcinomas 〔Ｊ〕. Int J Cancer (Pred Oncol), 1996; 69(3)∶212.
19.	Joseph A, Weiss GH, Jin L, et al. Expression of scatter factor in human bladder carcinoma 〔Ｊ〕. J Natl Cancer Inst, 1995; 87(5)∶372.
20.	Furukawa T, Duguid WP, Kobari M, et al. Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis 〔Ｊ〕. Am J Pathol, 1995; 147(4)∶889.
21.	Tsuka H, Mori H, Li B, et al. Expression of cmet/HGF receptor mRNA and protein in human nonmalignant and malignant prostate tissues 〔Ｊ〕. Int J Oncol, 1998; 13(5)∶927.
22.	Kiss A, Wang NJ, Xie JP, et al. Analysis of transforming growth factor (TGF)alpha/epidermal growth factor, hepatocyte growth factor/cmet, TGFbeta receptor type Ⅱ, and p53 expression in human hepatocellular carcinoma 〔Ｊ〕. Clin Cancer Res, 1997; 3(7)∶1059.
23.	Bussolino F, DI Renzo MF, Ziche M, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth 〔Ｊ〕. J Cell Biol, 1992; 119(3)∶629.

1. Di Renzo MF, Narsimhan RP, Olivero M, et al. Expression of the MET/HGF receptor in normal and neoplastic human tissues 〔Ｊ〕. Oncogene, 1997; 6(11)∶2003.
2. Matsumoto K, Nakamura T. Hepatocyte growth factor(HGF) as a tissue organizer for organogenesis and regeneration 〔Ｊ〕. Biochem Biophys Res Commun, 1997; 239(3)∶639.
3. Weidner KM, Behrens J, Vandekerckhove J, et al. Scatter factor: molecular characteristics and effect on invasiveness of epithelial cells 〔Ｊ〕. J Cell Biol, 1990; 111(5)∶2097.
4. Rosen EM, Knesel J, Goldberg ID, et al. Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor 〔Ｊ〕. Int J Cancer, 1994; 57(5)∶706.
5. Yamashita J, Ogawa M, Beppu T. Immunoreactive hepatocyte growth factor is present in tissue extracts from human breast cancer but not in conditioned medium of human breast cancer cell lines 〔Ｊ〕. Res Commun Chem Pathol Pharmacol, 1993; 82(2)∶249.
6. Rubin JS,Chan AM, Bottaro DP, et al. A broodspectrum human lung fibroblastderived mitogen is a variant of hepatocyte growth factor 〔Ｊ〕. Proc Natl Acad Sci USA, 1991; 88(2)∶415.
7. Rosenthal EL, Johnson TM, Allen ED, et al. Role of the plasminogen activator matrix metalloproteinase systems in epidermal growth factorand scatter factorstimulated invasion of carcinoma cells 〔Ｊ〕. Cancer Res, 1998; 58(22)∶5221.
8. Bostick PJ, Huynh KT, Sarantou T, et al. Detection of metastases in sentinel lymph nodes of breast cancer patients by multiplemarker RTPCR 〔Ｊ〕. Int J Cancer, 1998; 79(6)∶645.
9. Yamashita J, Ogawa M, Yamashita S, et al. Immunoreactive Hepatocyte Growth Factor is a strong and independent predictor of recurrence and survival in human breast cancer 〔Ｊ〕. Cancer Res, 1994; 54(7)∶1630.
10. Tsarfaty I, Alvord WG, Resau JH, et al. Alteration of Met Protooncogene product expression and prognosis in breast carcinomas 〔Ｊ〕. Anal Quant Cytol Histol, 1999; 21(5)∶397.
11. Seslar SP, Nakamura T, Stephen WB. Regulation of fibroblast hepatocyte growth factor/scatter factor expression by human breast carcinoma cell lines and peptide growth factors 〔Ｊ〕. Cancer Res, 1993; 53(6)∶1233.
12. Nakamura T, Matsumoto K, Kiritoshi A, et al. Induction of hepatocyte growth factor in fibroblasts by tumorderived factors affects invasive growth of tumor cells: in vitro analysis of tumorstromal interactions 〔Ｊ〕. Cancer Res, 1997; 57(15)∶3305.
13. Matsumoto TN, Matsumoto K, Nakamura T. Prostaglandin production in mouse mammary tumor cells confers in vasive growth potential by inducing hepatocyte growth factor in stromal fibroblasts 〔Ｊ〕. Br J Cancer, 1999; 81(2)∶194.
14. Kuniyasu H, Yasui W, Kitadai Y, et al. Frequent amplification of the cmet gene in scirrhous type stomach cancer 〔Ｊ〕. Biochem Biophys Res Commun, 1992; 189(1)∶227.
15. Liu C, Park M, Tsao MS. Overexpression of cmet protooncogene but not epidermal growth factor receptor or cerb B2 in primary human colorectal carcinomas 〔Ｊ〕. Oncogene, 1992; 7(1)∶181.
16. Schulte KM, Antoch G, Ellrichmann M, et al. Regulation of the HGFreceptor cmet in the thyroid gland 〔Ｊ〕. Exp Clin Endocrinol Diabetes, 1998; 106(4)∶310.
17. Di Renzo MF, Olivero M, Katsaros D, et al. Overexpression of the MET/HGF receptor in ovarian cancer 〔Ｊ〕. Int J Cancer, 1994; 58(5)∶658.
18. Natali PG, Prat M, Nicotra MR, et al. Overexpression of the met/HGF receptor in renal cell carcinomas 〔Ｊ〕. Int J Cancer (Pred Oncol), 1996; 69(3)∶212.
19. Joseph A, Weiss GH, Jin L, et al. Expression of scatter factor in human bladder carcinoma 〔Ｊ〕. J Natl Cancer Inst, 1995; 87(5)∶372.
20. Furukawa T, Duguid WP, Kobari M, et al. Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis 〔Ｊ〕. Am J Pathol, 1995; 147(4)∶889.
21. Tsuka H, Mori H, Li B, et al. Expression of cmet/HGF receptor mRNA and protein in human nonmalignant and malignant prostate tissues 〔Ｊ〕. Int J Oncol, 1998; 13(5)∶927.
22. Kiss A, Wang NJ, Xie JP, et al. Analysis of transforming growth factor (TGF)alpha/epidermal growth factor, hepatocyte growth factor/cmet, TGFbeta receptor type Ⅱ, and p53 expression in human hepatocellular carcinoma 〔Ｊ〕. Clin Cancer Res, 1997; 3(7)∶1059.
23. Bussolino F, DI Renzo MF, Ziche M, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth 〔Ｊ〕. J Cell Biol, 1992; 119(3)∶629.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE ADVANCE IN RESEARCHING INTO HEPATOCYTE GROWTH FACTOR AND RECEPTOR c-met IN BREAST CARCINOMA

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