SUN Libo , ZHANG Deheng , TIAN Li , et al.
  • Department of General Surgery, The Third Teaching Hospital, Bethune University of Medical Sciences, Changchun 130031;
Acute necrotic pancreatitis Antibiotic Protease inhibitor Regional arterial infusion
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Objective  To determine whether regional arterial infusion (RAI) of 5-Fu and imipenem could decrease infection and mortality of acute necrotic pancreatitis (ANP) or not.
Methods  Fifty three patients with ANP were devided into three groups, group A, 16 patients who received intravenous 5-Fu and imipenem, group B, 22 patients who received 5-Fu by RAI and imipenem intravenously, and group C, 15 patients who received both 5-Fu and imipenem by RAI.
Results  The incidence of infection of ANP in group C (0%) was significantly lower than that in group A (50.0%) and B (27.2%), and the mortality rates in group B (18.1%) and C (13.3%) were significantly reduced as compared with group C (43.8%).
Conclusion  RAI of 5-Fu and imipenem was effective in reducing ANP infection and mortality rates.

Citation： SUN Libo,ZHANG Deheng,TIAN Li,et al.. REGIONAL ARTERIAL INFUSION OF 5-Fu AND IMIPENEM DECREASES INFECTION AND MORTALITY OF ACUTE SEVERE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(6): 373-374. doi: Copy