TUMOR NECROSIS FACTOR-α AND GUT BARRIER DYSFUNCTION IN ACUTE PANCREATITIS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIA Penghui

Department of General Surgery, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;

Corresponding author：

Keywords：

Acute pancreatitis Tumor necrosis factor Gut barrier

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Objective To summarize the role of inflammatory cytokines in the pathogenesis of acute pancreatitis (AP) and gut barrier dysfunction in recent years.
Methods Literatures on cytokines and experimental pancreatitis as well as clinical pancreatitis were collected and reviewed.
Results Tumor necrosis factor-α and other inflammatory cytokines were elevated significantly during pancreatitis in many tissues, especially in pancreas and alimentary tract, in a fashion independent of the animal model used. Anti-cytokine therapy could decrease the concentration of the cytokines in experimental animal. Conclusion Inflammatory cytokines are believed to be primarily responsible for the pathogenesis of acute pancreatitis and its associated distant organ dysfunction. Further study of the nature of these cytokines may provide a new approach to treating this disease.

Citation： JIA Penghui,LIU Xbao.. TUMOR NECROSIS FACTOR-α AND GUT BARRIER DYSFUNCTION IN ACUTE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(6): 415-417. doi: Copy

1.	Kusske AM, Rongione AJ, Reber HA. Cytokines and acute pancreatitis 〔editorial; comment〕〔Ｊ〕. Gastroenterology, 1996; 110(2)∶639.
2.	Di Giovine FS, Stones S, Duff GW. Cytokines: identification and measurement of gene activation. Tumor immunobiology, a Practical Approach. New York: IRL Press, 1995∶159.
3.	Whiteside TL. Cytokine measurement and interpretation of cytokine assays in human disease 〔Ｊ〕. J Clin Immunol, 1994; 14(6)∶327.
4.	Aggarwal BB, Eessalu TE, Hass TE. Characterization receptor human tumor necrosis factor and their regulation by γinterferon 〔Ｊ〕. Nature， 1985； 318∶665.
5.	谷俊明. 肿瘤坏死因子在急性胰腺炎并发ARDS中的作用研究进展〔Ｊ〕. 中原医刊， 1996； 23(11)∶11.
6.	Norman J, Fink G, Denham W, et al. Tissue specific cytokine production during experimental pancreatitis: a probable mechanism for distant organ dysfunction 〔Ｊ〕. Dig Dis Sci, 1997; 42(8)∶1783.
7.	Grewal HP, Mohey ELDin A, Gaber L, et al. Amelioration of the physiologic and biochemical change of acute pancreatitis using an anti TNFalpha polyclonal antibody 〔Ｊ〕. Am J Surg, 1994; 167(1)∶214.
8.	Hughes CB, Gaber LW, Kotb M, et al. Induction of acute pancreatitis in germfree rats: evidence of a primary role for tumor necrosis factoralpha 〔Ｊ〕. Surgery, 1995; 117(2)∶201.
9.	Yasuo, Yamaguchi. In situ kinetics of acinar, duct, and inflammatory cells in duct ligationinduced pancreatitis in rats 〔Ｊ〕. Gastroenterology, 1993; 104(5)∶1498.
10.	Exley AR, Leese T, Holliday MP, et al. Endotoxaemia and serum tumor necrosis factor as prognostic markers in severe acute pancreatitis 〔Ｊ〕. Gut, 1992; 33(8)∶1126.
11.	Zhou ZG, Gao XH. Morphology of pancreatic microcirculation in the monkey: light and scanning electron microscopic study 〔Ｊ〕. Clin Anat, 1995; 8(3)∶190.
12.	Grewal HP, Kotb M, Mohey ELDin A, et al. Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage 〔Ｊ〕. Surgery, 1994; 115(2)∶213.
13.	De Beaux AC, Goldie AS, Ross JA, et al. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis 〔Ｊ〕. Br J Surg, 1996; 83(3)∶349.
14.	王志均主编. 细胞保护〔M〕. 第1版. 北京：北京医科大学中国协和医科大学联合出版社， 1995∶176～178.
15.	Wang XD, WANG Q, Anderssion R, et al. Alterations in intestinal function in acute pancreatitis in an experimental model 〔Ｊ〕. Br J Surg, 1996; 83(11)∶1537.
16.	Liu Q, Djuricin G, Nathan C, et al. The effect of epidermal growth factor on the septic complications of acute pancreatitis 〔Ｊ〕. J Surg Res, 1997; 69(1)∶171.
17.	Eubanks JW, Sabek O, Kotb M, et al. Acute pancreatitis induces cytokine production in endotoxinresistant mice 〔Ｊ〕. Ann Surg, 1998; 227(6)∶904.
18.	Davies MG, Hagen PO. Systemic inflammatory response syndrome 〔Ｊ〕. Br J Surg, 1997; 84(7)∶920.

1. Kusske AM, Rongione AJ, Reber HA. Cytokines and acute pancreatitis 〔editorial; comment〕〔Ｊ〕. Gastroenterology, 1996; 110(2)∶639.
2. Di Giovine FS, Stones S, Duff GW. Cytokines: identification and measurement of gene activation. Tumor immunobiology, a Practical Approach. New York: IRL Press, 1995∶159.
3. Whiteside TL. Cytokine measurement and interpretation of cytokine assays in human disease 〔Ｊ〕. J Clin Immunol, 1994; 14(6)∶327.
4. Aggarwal BB, Eessalu TE, Hass TE. Characterization receptor human tumor necrosis factor and their regulation by γinterferon 〔Ｊ〕. Nature， 1985； 318∶665.
5. 谷俊明. 肿瘤坏死因子在急性胰腺炎并发ARDS中的作用研究进展〔Ｊ〕. 中原医刊， 1996； 23(11)∶11.
6. Norman J, Fink G, Denham W, et al. Tissue specific cytokine production during experimental pancreatitis: a probable mechanism for distant organ dysfunction 〔Ｊ〕. Dig Dis Sci, 1997; 42(8)∶1783.
7. Grewal HP, Mohey ELDin A, Gaber L, et al. Amelioration of the physiologic and biochemical change of acute pancreatitis using an anti TNFalpha polyclonal antibody 〔Ｊ〕. Am J Surg, 1994; 167(1)∶214.
8. Hughes CB, Gaber LW, Kotb M, et al. Induction of acute pancreatitis in germfree rats: evidence of a primary role for tumor necrosis factoralpha 〔Ｊ〕. Surgery, 1995; 117(2)∶201.
9. Yasuo, Yamaguchi. In situ kinetics of acinar, duct, and inflammatory cells in duct ligationinduced pancreatitis in rats 〔Ｊ〕. Gastroenterology, 1993; 104(5)∶1498.
10. Exley AR, Leese T, Holliday MP, et al. Endotoxaemia and serum tumor necrosis factor as prognostic markers in severe acute pancreatitis 〔Ｊ〕. Gut, 1992; 33(8)∶1126.
11. Zhou ZG, Gao XH. Morphology of pancreatic microcirculation in the monkey: light and scanning electron microscopic study 〔Ｊ〕. Clin Anat, 1995; 8(3)∶190.
12. Grewal HP, Kotb M, Mohey ELDin A, et al. Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage 〔Ｊ〕. Surgery, 1994; 115(2)∶213.
13. De Beaux AC, Goldie AS, Ross JA, et al. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis 〔Ｊ〕. Br J Surg, 1996; 83(3)∶349.
14. 王志均主编. 细胞保护〔M〕. 第1版. 北京：北京医科大学中国协和医科大学联合出版社， 1995∶176～178.
15. Wang XD, WANG Q, Anderssion R, et al. Alterations in intestinal function in acute pancreatitis in an experimental model 〔Ｊ〕. Br J Surg, 1996; 83(11)∶1537.
16. Liu Q, Djuricin G, Nathan C, et al. The effect of epidermal growth factor on the septic complications of acute pancreatitis 〔Ｊ〕. J Surg Res, 1997; 69(1)∶171.
17. Eubanks JW, Sabek O, Kotb M, et al. Acute pancreatitis induces cytokine production in endotoxinresistant mice 〔Ｊ〕. Ann Surg, 1998; 227(6)∶904.
18. Davies MG, Hagen PO. Systemic inflammatory response syndrome 〔Ｊ〕. Br J Surg, 1997; 84(7)∶920.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

TUMOR NECROSIS FACTOR-α AND GUT BARRIER DYSFUNCTION IN ACUTE PANCREATITIS

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