THE SIGNIFICANCE OF TUMOR SUPRESSOR GENES INACTIVATION IN CARCINOGENESIS OF MULTIPLE PRIMARY NEOPLASM_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Yi

Department of General Surgery, South West Hospital, The Third Military Medical University, Chongqing 400038;

Corresponding author：

Keywords：

Tumor suppressor gene Multiple primary malignant neoplasm Tumourigenesis

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Objective To investigate the effect of tumor suppressor gene on tumourigenesis in multiple primary malignant neoplasm (MPMN).
Methods The retrospective analysis was used to summarize several common tumor suppressor genes correlation to MPMN.
Results At current study of the tumor suppressor genes, the common genes studied in MPMN were p53, APC, p16, BRCA1, BRCA2 and PTEN/MMAC1, etc. The same mutation of tumor suppressor genes could be detected from PMNNs.
Conclusion There are significant relations between MPMN and inactivation of tumor suppressor gene. By the study of tumor suppressor gene, it can reveal some common rules of tumourigenesis of MPMN.

Citation： ZHANG Yi,JIANG Jun.. THE SIGNIFICANCE OF TUMOR SUPRESSOR GENES INACTIVATION IN CARCINOGENESIS OF MULTIPLE PRIMARY NEOPLASM. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(6): 418-420. doi: Copy

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14.	Radrord DM, Zehnbamer BA. Inherited breast cancer 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶205.
15.	Couch FJ, Deshano ML, Blackwood MN, et al. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer 〔Ｊ〕. N Engl J Med, 1997; 336(20)∶1409.
16.	Easton DF, Narod SA, Fofd D, et al. The genetic epidemiology of BRCA1 〔Ｊ〕. Lancet, 1994; 344(8924)∶761.
17.	Wooster R, Mangion J, Nevhausen SL, et al. Localization of a breast cancer susceptibility gene, BRCA2 to chromosome 13q1223 〔Ｊ〕. Science, 1994; 265(5181)∶2098.
18.	Donegan WL, Redlich PN. Breast cancer in men 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶343.
19.	Kamb A, Gruis N, Liu QY, et al. A cell cycle regulator potentially involved in genesis of many tumor types 〔Ｊ〕. Science, 1994; 264(5157)∶436.
20.	Nobori T, Miura K, Wu DJ, et al. Deletions of the cyclindependent kinase4 inhibitor gene in multiple human cancers 〔Ｊ〕. Nature, 1994; 368(6467)∶753.
21.	Masx J. New tumor suppressor may rival p53 〔Ｊ〕. Science, 1994; 264(5157)∶344.
22.	Monzon J, Liu L， Brill H, et al. CDKN2A mutations in multiple primary melanomas 〔Ｊ〕. N Engl J Med, 1998; 338(13)∶879.
23.	Rhel E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumour suppressor gene PTEN/MMAC1 in primary breast carcinomas 〔Ｊ〕. Cancer Res, 1997; 57(17)∶3657.
24.	Kinzler KW, Vogelstien B. Gatekeepers and caretaker 〔Ｊ〕. Nature, 1997; 386(6626)∶761.
25.	Sharan SK, Morimatsu M, Albrecht V, et al. Embryonic lethality and radiation hypersensitivity mediated by rad51 in mice lacking BRCA2 〔Ｊ〕. Nature, 1997; 386(6626)∶804.

1. Miki Y, Swensen J, Shattuck K, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 〔Ｊ〕. Science, 1994; 266(5188)∶66.
2. Sinicrope FA, Rvan SB, Cleary RR, et al. Bcl2 and p53 oncoprotein expression during colorectal tumorigenes 〔Ｊ〕. Cancer Res, 1995; 55(2)∶237.
3. Harris CG. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies 〔Ｊ〕. J Natl Cancer Inst, 1996; 88(20)∶1442.
4. Mitsudomi T, Yatabe Y, Kosshikawa T, et al. Mutations of the p53 tumor suppressor gene as clonal marker for multiple primary lung cancers 〔Ｊ〕. J Thorac Cardiovasc Surg, 1997; 114(3)∶354.
5. Hisada M, Garber JE, Fung CY, et al. Multiple primary cancers in families with LiFraumeni syndrome 〔Ｊ〕. J Notl Cancer Inst, 1998; 90(8)∶606.
6. Alconchel MD, Olivares C, Alvarez R, et al. Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars 〔Ｊ〕. Br J Dermatol, 1997; 137(5)∶793.
7. Sparks AB, Morin PJ, Vogolstegn B, et al. Mutational analuyusis of the APC/βcatenin/TCF pathway in colorectal cancer 〔Ｊ〕. Cancer Res, 1998; (6)∶1130.
8. Mahmoud NN, Boolbol SK, Bilinski RT, et al. APC gene mutations is assoceated with a dominantnegative effect up intestinal cell migration 〔Ｊ〕. Cancer Res, 1997; 57(22)∶5045.
9. Milner J, Ponder B, Davies L, et al. Transcriptional activation 〔Ｊ〕. Nature, 1997; 386(6626)∶772.
10. Gorden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene 〔Ｊ〕. Cell, 1991; 66(3)∶589.
11. Winchester DP. Breast cancer in young women 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶279.
12. Easton DF, Bishop DT, Ford D, et al. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families 〔Ｊ〕. Am J Hum Genet, 1993; 52(4)∶678.
13. Durocher F, Tonin P, Shattuck ED, et al. Mutation analysis of the BRCA1 gene in 23 families with cancers of the breast ovary and multiple other sites 〔Ｊ〕. J Med Genet, 1996; 33(11)∶814.
14. Radrord DM, Zehnbamer BA. Inherited breast cancer 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶205.
15. Couch FJ, Deshano ML, Blackwood MN, et al. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer 〔Ｊ〕. N Engl J Med, 1997; 336(20)∶1409.
16. Easton DF, Narod SA, Fofd D, et al. The genetic epidemiology of BRCA1 〔Ｊ〕. Lancet, 1994; 344(8924)∶761.
17. Wooster R, Mangion J, Nevhausen SL, et al. Localization of a breast cancer susceptibility gene, BRCA2 to chromosome 13q1223 〔Ｊ〕. Science, 1994; 265(5181)∶2098.
18. Donegan WL, Redlich PN. Breast cancer in men 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶343.
19. Kamb A, Gruis N, Liu QY, et al. A cell cycle regulator potentially involved in genesis of many tumor types 〔Ｊ〕. Science, 1994; 264(5157)∶436.
20. Nobori T, Miura K, Wu DJ, et al. Deletions of the cyclindependent kinase4 inhibitor gene in multiple human cancers 〔Ｊ〕. Nature, 1994; 368(6467)∶753.
21. Masx J. New tumor suppressor may rival p53 〔Ｊ〕. Science, 1994; 264(5157)∶344.
22. Monzon J, Liu L， Brill H, et al. CDKN2A mutations in multiple primary melanomas 〔Ｊ〕. N Engl J Med, 1998; 338(13)∶879.
23. Rhel E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumour suppressor gene PTEN/MMAC1 in primary breast carcinomas 〔Ｊ〕. Cancer Res, 1997; 57(17)∶3657.
24. Kinzler KW, Vogelstien B. Gatekeepers and caretaker 〔Ｊ〕. Nature, 1997; 386(6626)∶761.
25. Sharan SK, Morimatsu M, Albrecht V, et al. Embryonic lethality and radiation hypersensitivity mediated by rad51 in mice lacking BRCA2 〔Ｊ〕. Nature, 1997; 386(6626)∶804.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE SIGNIFICANCE OF TUMOR SUPRESSOR GENES INACTIVATION IN CARCINOGENESIS OF MULTIPLE PRIMARY NEOPLASM

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