• Department of Respiratory Medicine, The Affiliated Drum Tower Hospital, Nanjing University Medical College. Nanjing, Jiangsu,210008, China;
Idiopathic pulmonary fibrosis; Acute exacerbation; Diagnosis; Therapy; Prognosis
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Objective  To improve the awareness of acute exacerbation of idiopathic pulmonary fibrosis ( AEIPF) and discuss its clinical characteristics, diagnosis, treatment and outcome.
Methods  The clinical data of patients with AEIPF from June 2006 to June 2011 in 11 hospitals in Jiangsu were collected and analyzed.
Resluts  There were 18 males and 3 females in the AEIPF patients with mean age of ( 67.4 ± 8.1) years. The duration from IPF diagnosis was ( 7.4 ±8.2) months. The duration of acute symptom before admission was ( 7.0 ±5.3) days. The distribution pattern of new groud-glass opacity was peripheral in 3 patients,multifocal in 5 patients, and diffuse in13 patients. All patients were treated with corticosteroid pulse therapy. Nine patients survived and 12 patients died. The mortality rate was 57.1% .
Conclusions  AEIPF progresses quickly and the mortality rate is very high. Corticosteroid pulse therapy is the mainstay of therapy in AEIPF patients.

Citation： LIU Yin,CAI Liming,ZHAO Hongqing,HUANG Qian,ZHU Shuyang,CHEN Bi,WU Feng,ZHENG Yulong,YAN Yulan,LI Yuqing,ZHANG Xiuwei,WU Yumin,ZHANG Deping. Acute Exacerbation of Idiopathic Pulmonary Fibrosis: Clinical Analysis of 21 Cases. Chinese Journal of Respiratory and Critical Care Medicine, 2012, 11(4): 362-366. doi: Copy