The influence of gastroesophageal reflux on the acidity of airway and pulmonary ventilation function in acute exacerbation of chronic obstructive pulmonary disease patient_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 XU Jian ¹ , LIU Ao ² , ZOU Lei ³

Kunming Medical College，Kunming General Hospital of Chengdu Military Region．Kunming，Yunnan，650032，ChinaCorresponding author：XU Jian．E—mail：xjpop1981@163.com;

Corresponding author：

XU Jian, Email: xjpop1981@163.com

Keywords：

Chronic obstructive pulmonary disease; Acute exacerbation; Gastr0esophageal reflux; Airway; Expired breath condensate; pH; Lung functio

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0bjective To investigate the prevalence of gastroesophageal reflux(GER)in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and to explore the influence of GER on the acidity of airway and pulmonary ventilation function in AECOPD patients．Methods Sixty-five hospitalized AECOPD patients and 20 healthy volunteers were enrolled in this study．According to “GER survey”questionnaire，AECOPD patients were allocated into GER group and non-GER group and expired breath condensate(EBC)pH and pulmonary ventilation function were detected．Breath condensate samples were collected using a specially designed condensing chamber(EcoScreen，Germany)．Results About 30.8％ (20／65)AECOPD patients were complicated with GER．EBC pH was lowest in GER group，middle in non-GER group and highest in the control group[6.oo±0.75 VS 6.76±0.77 and 7.97±0.12，both P lt;0.05)．The pulmonary ventilation function(FEV1、FEV1％pred)in AECOPD patients with GER were lower than those without GER(both P lt;0.05)．Conclusions There iS a high prevalence of GER in AECOPD patients．And the airway pH is reduced in AECOPD patients，especially when complicated with GER，which may play an important role in the development of COPD．

Citation： XU Jian,LIU Ao,ZOU Lei. The influence of gastroesophageal reflux on the acidity of airway and pulmonary ventilation function in acute exacerbation of chronic obstructive pulmonary disease patient. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 448-451. doi: Copy

1.	Kiljander TO，Laitinen Jo．，The prevalence of gastroesophageal reflux disease in adult asthmatics．Chest，2004，126：1490-1494．.
2.	1 Dent J，El-Scrag HB，Wallander MA，et al．Epidemiology of gastrooesophageal reflux disease：a systematic review．Gut，2005，54：710-717．.
3.	Debley JS，Carter ER，Redding GJ，et al．Prevalence and impact of gastroesophageal reflux in adolescents with asthma：a populationbased study．Pediatr Pulmonol，2006，41：475-481．.
4.	Mokhelsi B，Morris AL，Huang CF，et al．Increased prevalence of gastroesophageal reflux in patients with COPD．Chest，2001，1 19：1043-1048．.
5.	Shimizu Y，Dobashi K，Zhao JJ，et al．Proton Proton pump inhibitor improves breath marker in moderate asthma with gastroesophageal reflux disease．Respiration，2007，74：558-564．.
6.	Mokhlesi B．Clinical implications of gastroesophageal reflux disease and swallowing dysfunction in COPD．Am J Respir Med，2003，2，117-121．.
7.	Phulpoto MA，Qayyum S，Rizvi N，et al．Proportion of gastroesophageal reflux symptoms in patients with chronic obstructive pulmonary disease．J Pak Med Assoc，2005．55：276-279．.
8.	Mokhlesi B，Morris AL，Huang CF，et al．Increased prevalence of gastroesophageal reflux symptoms in patients with COPD．Chest，2001，19：1043-1048．.
9.	李翠萍，刘雪白，周秀梅，等．慢性阻塞性肺疾病应用抗胃食管反流治疗的探讨．中华I临床医师杂志(电子版)，2007，1：105-106．.
10.	王萍，秦雪冰，王瑞娟，等．胃食管反流与慢性阻塞性肺疾病急性加重的关系探讨．中国呼吸与危重监护杂志，2007，6：177-193．.
11.	Kempainen RR，Savik K，Whelan TP，et al．High prevalence of proximal and distal gastroesophageal reflux disease in advanced COPD．Chest，2007，131：1666-1671．.
12.	余涛，于皆平，耿红，等．抗胃食管反流治疗对慢性阻塞性肺病患者肺通气功能的影响．中国临床医学，2003，10：821-832．.
13.	胃食管反流病研究协作组．反流性疾病问卷在胃食管反流病诊断中的价值．中华消化杂志，2003，23：651-654．.
14.	Kostikas K，Papatheodorou G，Ganas K，et al．pH in expired breath condensate of patients with infammatory airways diseases．Am J Respir Crit Care Med，2002，165：1364-1370．.
15.	Haritonov SA．Barnes P Exhaled markers of pulmonary disease．Am J Respir Crit Care Med，2001，163：1693-1722．.
16.	Manterola C，Munoz S，Grande L，et al．Initial validation of a ques tionnaire for detecting gastroesophageal reflux disease in epidemiological settings．J Clin Epidemiol，2002，55：1041-1045．.
17.	Phulpoto MA，Qayyum S，Rizvi N，et al．Proportion of gastroesophageal reflux symptoms in patients with chronic obstructive pulmonary disease．J Pak Med Assoc，2005，55：276-279．.

1. Kiljander TO，Laitinen Jo．，The prevalence of gastroesophageal reflux disease in adult asthmatics．Chest，2004，126：1490-1494．.
2. 1 Dent J，El-Scrag HB，Wallander MA，et al．Epidemiology of gastrooesophageal reflux disease：a systematic review．Gut，2005，54：710-717．.
3. Debley JS，Carter ER，Redding GJ，et al．Prevalence and impact of gastroesophageal reflux in adolescents with asthma：a populationbased study．Pediatr Pulmonol，2006，41：475-481．.
4. Mokhelsi B，Morris AL，Huang CF，et al．Increased prevalence of gastroesophageal reflux in patients with COPD．Chest，2001，1 19：1043-1048．.
5. Shimizu Y，Dobashi K，Zhao JJ，et al．Proton Proton pump inhibitor improves breath marker in moderate asthma with gastroesophageal reflux disease．Respiration，2007，74：558-564．.
6. Mokhlesi B．Clinical implications of gastroesophageal reflux disease and swallowing dysfunction in COPD．Am J Respir Med，2003，2，117-121．.
7. Phulpoto MA，Qayyum S，Rizvi N，et al．Proportion of gastroesophageal reflux symptoms in patients with chronic obstructive pulmonary disease．J Pak Med Assoc，2005．55：276-279．.
8. Mokhlesi B，Morris AL，Huang CF，et al．Increased prevalence of gastroesophageal reflux symptoms in patients with COPD．Chest，2001，19：1043-1048．.
9. 李翠萍，刘雪白，周秀梅，等．慢性阻塞性肺疾病应用抗胃食管反流治疗的探讨．中华I临床医师杂志(电子版)，2007，1：105-106．.
10. 王萍，秦雪冰，王瑞娟，等．胃食管反流与慢性阻塞性肺疾病急性加重的关系探讨．中国呼吸与危重监护杂志，2007，6：177-193．.
11. Kempainen RR，Savik K，Whelan TP，et al．High prevalence of proximal and distal gastroesophageal reflux disease in advanced COPD．Chest，2007，131：1666-1671．.
12. 余涛，于皆平，耿红，等．抗胃食管反流治疗对慢性阻塞性肺病患者肺通气功能的影响．中国临床医学，2003，10：821-832．.
13. 胃食管反流病研究协作组．反流性疾病问卷在胃食管反流病诊断中的价值．中华消化杂志，2003，23：651-654．.
14. Kostikas K，Papatheodorou G，Ganas K，et al．pH in expired breath condensate of patients with infammatory airways diseases．Am J Respir Crit Care Med，2002，165：1364-1370．.
15. Haritonov SA．Barnes P Exhaled markers of pulmonary disease．Am J Respir Crit Care Med，2001，163：1693-1722．.
16. Manterola C，Munoz S，Grande L，et al．Initial validation of a ques tionnaire for detecting gastroesophageal reflux disease in epidemiological settings．J Clin Epidemiol，2002，55：1041-1045．.
17. Phulpoto MA，Qayyum S，Rizvi N，et al．Proportion of gastroesophageal reflux symptoms in patients with chronic obstructive pulmonary disease．J Pak Med Assoc，2005，55：276-279．.

Chinese Journal of Respiratory and Critical Care Medicine

The influence of gastroesophageal reflux on the acidity of airway and pulmonary ventilation function in acute exacerbation of chronic obstructive pulmonary disease patient

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