Negative signaling molecules of human mast cells and allergic diseases_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

REN Yanli ¹ , QI Zhongtian ¹ ,  LI Li ²

Corresponding author：

LI Li, Email: annylish@hotmail.com

Keywords：

肥大细胞负调控分子; 变态反应性疾病

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Citation： REN Yanli,QI Zhongtian,LI Li. Negative signaling molecules of human mast cells and allergic diseases. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 485-487. doi: Copy

1.	Ferreira F，Briza P，Infuhr D，et al.Modified recombinant allergens for safer immunotherapy.Inflamm Allergy Drug Targets，2006，5：5-14.
2.	Oliver JM，Kepley CL，Ortega E，et al.Immunologically mediated signaling in basophils and mast cells：finding therapeutic targets for allergic diseases in the human FcvarepsilonR1 signaling pathway.Immunopharmacology，2000，48，269-281.
3.	Daeron M.Fc receptor biology.Annu Rev Immunol，1997，15：203-234.
4.	Kihara H，Siraganian RP.Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.J Biol Chem，1994，269：22427-22432.
5.	Daëron M，Malbec O，Latour S，et al.Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.J Clin Invest，1995，95：577-585.
6.	Malbec O，Fong DC，Turner M，et al.Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation.J Immuneol，1998，160：1647-1658.
7.	Ono M，Bolland S，Tempst P，et al.Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc（gamma）RIIB.Nature，1996，383：263-266.
8.	Fong DC，Malbec O，Arock M，et al.Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation.Immunol Lett，1996，54：83-91.
9.	Huber M，Helgason CD，Damen JE，et al.The src homology 2-containing inositol phophatase（SHIP） is the gatekeeper of mast cell degranulation.Proc Natl Acad Sci USA，1998，95：11330-11335.
10.	Zhu D，Kepley CL，Zhang M，et al.A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation.Nat Med，2002，8：518-521.
11.	Huston JS，Levinson D，Mudgett-Hunter M，et al.Protein engineering of antibody binding site：recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.Proc Natl Acad Sci USA，1998，85：5879-5833.
12.	Helm B，Marsh P，Vercelli D，et al.The mast cell binding site on human immunoglobulin E.Nature，1998，331：180-183.
13.	Kepley CL，Zhang K，Zhu D，et al.FcεRI-FcγRII coaggregation inhibits IL-16 production from human Langerhans-like dendritic cells.Clin Immunol，2003，108：89-94.
14.	Tam SW，Demissie S，Thomas D，et al.A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils.Allergy，2004，59：772-780.
15.	Kepley CL，Taghavi S，Mackay G，et al.Co-aggregation of FcγRII with FcεRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes.JBC，2004，279：35139-35149.
16.	Zhu D，Zhang K，Kepley CL，et al.A chimeric human-cat fusion protein blocks cat-induced allergy.Nat Med，2005，11：446-449.
17.	Terada T，Zhang K，Belperio J，et al.A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic，pulmonary，and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1，the major cat allergen.Clin Immunol，2006，120：45-56.

1. Ferreira F，Briza P，Infuhr D，et al.Modified recombinant allergens for safer immunotherapy.Inflamm Allergy Drug Targets，2006，5：5-14.
2. Oliver JM，Kepley CL，Ortega E，et al.Immunologically mediated signaling in basophils and mast cells：finding therapeutic targets for allergic diseases in the human FcvarepsilonR1 signaling pathway.Immunopharmacology，2000，48，269-281.
3. Daeron M.Fc receptor biology.Annu Rev Immunol，1997，15：203-234.
4. Kihara H，Siraganian RP.Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.J Biol Chem，1994，269：22427-22432.
5. Daëron M，Malbec O，Latour S，et al.Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.J Clin Invest，1995，95：577-585.
6. Malbec O，Fong DC，Turner M，et al.Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation.J Immuneol，1998，160：1647-1658.
7. Ono M，Bolland S，Tempst P，et al.Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc（gamma）RIIB.Nature，1996，383：263-266.
8. Fong DC，Malbec O，Arock M，et al.Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation.Immunol Lett，1996，54：83-91.
9. Huber M，Helgason CD，Damen JE，et al.The src homology 2-containing inositol phophatase（SHIP） is the gatekeeper of mast cell degranulation.Proc Natl Acad Sci USA，1998，95：11330-11335.
10. Zhu D，Kepley CL，Zhang M，et al.A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation.Nat Med，2002，8：518-521.
11. Huston JS，Levinson D，Mudgett-Hunter M，et al.Protein engineering of antibody binding site：recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.Proc Natl Acad Sci USA，1998，85：5879-5833.
12. Helm B，Marsh P，Vercelli D，et al.The mast cell binding site on human immunoglobulin E.Nature，1998，331：180-183.
13. Kepley CL，Zhang K，Zhu D，et al.FcεRI-FcγRII coaggregation inhibits IL-16 production from human Langerhans-like dendritic cells.Clin Immunol，2003，108：89-94.
14. Tam SW，Demissie S，Thomas D，et al.A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils.Allergy，2004，59：772-780.
15. Kepley CL，Taghavi S，Mackay G，et al.Co-aggregation of FcγRII with FcεRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes.JBC，2004，279：35139-35149.
16. Zhu D，Zhang K，Kepley CL，et al.A chimeric human-cat fusion protein blocks cat-induced allergy.Nat Med，2005，11：446-449.
17. Terada T，Zhang K，Belperio J，et al.A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic，pulmonary，and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1，the major cat allergen.Clin Immunol，2006，120：45-56.

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