SHI Zongdao 1 , WANG Xiaoyi 1 , CHEN Ziyi 2 , YANG Xiaomin 3 , CHEN Xinmei 1 , XU Baohua 1 , ZENG Hongbin 1 , CHEN Hui 2 , CHENG Junjie 2 , LI Zheng 3 , FBI Wei 3 , HUANG Dingming 1 , CHEN E 1 , CHANG Ting 1
  • 1. West China Stomatological Hospital; Sichuan University2. Stomatological Hospital; Zhejiang University3. Sichuan Provincial Hospital; Chengdu 610041 China;
Mepivacaine; local anesthesia; safety; randomization; double blinded; clinical trial
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Objective 　To assess efficacy of mepivacaine on local anesthesia in dentistry and oral surgery and its safety.
Methods 　Parallel group, stratified randomization, double blinded, muti-center clinical trial was designed. Two percent lidocaine with adrenaline in same cartridge was as control. Healthy patients with deep decay, pulpitis needed operative dentistry, or indication for extraction of the teeth, which located in the maxilla or front part of the mandible were included.
Results 　Except 17 cases, 127 patients fulfilled inclusion criteria: 66 in treatment group and 61 in control group, dental filling for 60 and extraction for 67 cases, male 55 and female 72, average at 38.84 + 12.06 years. Submucous infiltration of 1.5 ml mepivacaine at labial or buccal side of the alveolar process produced onset of anesthesia in the median of 60 seconds which was same as that of lidocaine, anesthesia duration for 146.7 minutes with the median of 125 minutes, permitting painless filling or extractions. In the treatment group 81.82% freed of pain, while 15.15% had slight pain but received no extra local anesthetic for implementation of the treatment procedures, making the successful rate of 96.97%. In the mepivacaine group, 13.64% of the cases had transient elevation of the systolic pressure to the level of 145-162 mmHg, 8.33% diastolic pressure to the level of 91-93 mmHg. Only one case had transient palpitation in half minute after one minute injection of the drug with no medical care needed. All the cardiovascular reactions might result from adrenaline containing in the injections.
Conclusion 　Mepivacaine is an effective, safe and reliable anesthetic agent for dentistry and oral surgery.

Citation： SHI Zongdao,WANG Xiaoyi,CHEN Ziyi,YANG Xiaomin,CHEN Xinmei,XU Baohua,ZENG Hongbin,CHEN Hui,CHENG Junjie,LI Zheng,FBI Wei,HUANG Dingming,CHEN E,CHANG Ting. Multi-center randomized double-blinded controlled clinical t ri al on local anesthetic efficacy of scndonest 2% special and its safety. Chinese Journal of Evidence-Based Medicine, 2002, 02(2): 86-91. doi: Copy