Objective To investigate perindopiI influence for the complication in hypertensive patients with stroke history by lowering blood pressure.
Methods One-hundred and fifty-five essential hypertensive patients with stroke history were randomly assigned to either perindopril group or placebo group, receiving a randomized, double-blind, placebo-controlled trial as long as 3 years. Their blood pressure, the morbidity and mortality of cardiocerebral complications were monitored. At the end of trial, three days Ambulatory Blood Pressure Monitoring were performed.
Result It was shown that in perindopril group blood pressure was controlled satisfactorily, and the morbidity and mortality of cardiocerebral incidences (6.85 % and 2.74 %repectively) were lower than those of placebo group (17.10% and 9.21% respectively).
Conclusions Perindopril lowers blood pressure effectively and persistently. It has important clinical effect for prevention the cardiocerebral complications in hypertensive patients with stroke history by lowering blood pressure.
Citation： LU Fanghong,WEI Fang,YE Lin,WU Fan,TIAN Qi,SUN Hui,LI Yuyang. Clinical trial of perindopril influence for the complication in hypertensive patients with stroke history by lowering blood pressure. Chinese Journal of Evidence-Based Medicine, 2002, 02(3): 162-166. doi: Copy