WANG Li 1 , LIU Jiangping 1 , XIONG Wei 2 , KUANG Pu 2 , TAO Tiejun 2
  • 1. Chinese Evidence-Based Medicine/Cochrane Center; West China Hospital; Sichuan University2. West China Medical School; Sichuan University; Chengdu 610041; China;
HIV screening; HIV test; HIV infection; HIV-Seroprevalence; blood donor; systematic review; protocol
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Background 　AIDS (acquired immune deficiency syndrome) has become the most devastating disease which humankind has ever encountered. Human immune-deficiency virus (HIV) is transmitted through blood, sexual behavior and mother-to-baby, with more efficient transmission through blood transfusion. HIV risk among blood transfusion was severe due to lack of effective and correctly applied screening method and rigorous management, especially in some developing countries. Since the first HIV screening reagent was approved by FDA to screen the blood in 1985, the fourth generation test has been produced till now. Initially, HIV test was primarily used to screen the blood supply, it also became an important aspect of HIV prevention, especially screening among people donating blood. Today, HIV testing is seen as an integral part of both the nation’s prevention and treatment efforts.
Objective 　To assess the effectiveness of any intervention tests for HIV screening among people donating blood, and find appropriate tests for HIV screening to decrease the risk of HIV transmission by blood transfusion.
Search strategy 　MEDLINE, Cochrane Controlled Trials Register (CENTRAL/CCTR), AIDSLINE, EMBASE, CBM were be searched with the terms: "HIV", "AIDS", "screening", "test", "blood donor", "blood bank" and the detailed screening method. The websites of WHO, UNAIDS, CDC, FDA, and their related links were searched. Letters were mailed to various agencies and experts in this field to acquire unpublished reports.
Inclusion criteria 　RCT and CCT for screening HIV among blood. donors will be included. Observational studies such as cohort studies, cased-control studies, and historical controlled studies will be used for sensitivity analysis.
Method of the review 　According to the principles of Cochrane Review, selection of trials for inclusion, quality assessment of studies, data extraction and syntheses were conducted by reviewers.

Citation： WANG Li,LIU Jiangping,XIONG Wei,KUANG Pu,TAO Tiejun. Interventions to screen for human immune-deficiency virus among people donating blood[Protocol]. Chinese Journal of Evidence-Based Medicine, 2002, 02(3): 173-178. doi: Copy