Objective To review the efficacy and safety of interventions for preventing infections in nephrotic syndrome using evidence-based principles for clinicians to practice easily.
Methods We searched Cochrane controlled trials register database, MEDLINE, EMBASE and Chinese Biologic Medical database.
Results Total 11 articles were obtained including RCTs, non-controlled clinical studies and traditional narrative reviews. No systematic review or meta-analysis was identified. Prophylactic interventions for reducing risks of infection in nephrotic syndrome included intravenous immunoglobulin, thymosin, traditional Chinese herb, lamivudine, pneumococcal vaccination and chemoprophylaxis.
Conclusion At present, the studies about interventions for preventing infection in nephrotic syndrome were limited in quantity and poor in the quality of methodology, therefore, the promising conclusions were unavailable. Rigid randomized placebo-controlled clinical trials with blinding or systematic review or meta-analysis would be very necessary for further assessing the efficacy and safety of the prophylactic interventions for preventing infections in nephrotic syndrome
Citation： CAO Li,WU Hongmei,ZHANG Yanling,SHA Zhaohui. Evidence of Preventing Infections in Nephrotic Syndrome. Chinese Journal of Evidence-Based Medicine, 2003, 03(4): 321-326. doi: Copy