HE Jidong , WANG Yiping
  • Gastrointestinal disease Department of West China Hospital, Sichuan University, Chengdu 610041;
WANG Yiping, Email: hjdshare@sina.com
Helicobacter pylori; Functional dyspepsia; Clinical evidence
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Objective 　To provide evidence of the role of helicobacter pylori eradication in the treatment of functional dyspepsia.
Methods 　We searched VIP, CBMdisc, MEDLINE and The Cochrane Library for systematic reviews, meta-analysis, randomized controlled trials and clinical guidelines involving helicobacter pylori and functional dyspepsia, so as to provide the best evidence for clinical practice.
Results 　We included two systematic reviews, one meta-analysis and eleven randomized controlled trials. The evidence identified showed that helicobacter pylori infection was more prevalent in functional dyspepsia than in asymptomatic patients, but the effect of H pylori infection in the pathogenesis of functional dyspepsia remained controversial. H pylori eradication therapy had a relatively weak effect in H pylori positive functional dyspepsia. An economic model suggested that this modest benefit may still be cost-effective, but more studies are needed to assess this.
Conclusion 　According to the current evidence, it can be concluded that helicobacter pylori eradication for the treatment of functional dyspepsia should be individualized.

Citation： HE Jidong,WANG Yiping. Clinical Evidence of H Pylori Eradication in Functional Dyspepsia. Chinese Journal of Evidence-Based Medicine, 2007, 07(1): 66-70. doi: Copy