Lung Cancer Chemoprevention with Inhaled Corticosteroids?_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WANG Changzhen

Institute of Respiratory Disease, Xinqiao Hospital, The Third Military Medical University. Chongqing 400037 China;

Corresponding author：

Keywords：

激素; 肺癌

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1976年Sporn等[1]提出“化学预防（chemoprevention）”的概念，指用化学药物和饮食来干预肿瘤的发生过程，从而降低肿瘤的发生危险。化学预防对乳腺癌、结肠癌和前列腺癌等肿瘤的作用已有很多的研究，并取得了一些可喜的进展，但在肺癌领域进展甚微。1996年在《新英格兰医学杂志》上发表的b-胡萝卜素联合维生素A用于肺癌化学预防的报道[2]，让人大失所望。曾经认为β-胡萝卜素和维生素A具有“抗癌”作用，这项研究发现用β-胡萝卜素和维生素A长期干预肺癌高危人群，干预组患肺癌的相对风险显著高于安慰剂对照组，相对风险为1.28（95％可信区间1.04~1.57，P=0.02），肺癌发生的风险不降反升。最新的Meta分析资料也显示β-胡萝卜素增加吸烟者患肺癌的风险[3]。近年来肺癌的化学预防研究一直处于“低谷”之中。

Citation： WANG Changzhen. Lung Cancer Chemoprevention with Inhaled Corticosteroids?. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(3): 161-162. doi: Copy

1.	Sporn MB，Dunlop NM，Newton DL，et al.Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).Fed Proc，1976，35：1332-1338.
2.	Omenn GS，Goodman GE，Thornquist MD，et al.Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.N Engl J Med，1996，334：1150-1155.
3.	Tanvetyanon T，Bepler G.Beta-carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers：a meta-analysis and evaluation of national brands.Cancer. 2008 Apr 21 Epub ahead of print.
4.	Parimon T，Chien JW，Bryson CL，et al.Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med，2007，175：712-719.
5.	Khan A，Agarwal R.Lung Cancer Chemoprevention with Inhaled Corticosteroids? Am J Respir Crit Care Med，2007，176：1169.
6.	Buring JE，Hennekens CH.beta-carotene and cancer chemoprevention.J Cell Biochem Suppl， 1995，22：226-230.

1. Sporn MB，Dunlop NM，Newton DL，et al.Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).Fed Proc，1976，35：1332-1338.
2. Omenn GS，Goodman GE，Thornquist MD，et al.Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.N Engl J Med，1996，334：1150-1155.
3. Tanvetyanon T，Bepler G.Beta-carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers：a meta-analysis and evaluation of national brands.Cancer. 2008 Apr 21 Epub ahead of print.
4. Parimon T，Chien JW，Bryson CL，et al.Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med，2007，175：712-719.
5. Khan A，Agarwal R.Lung Cancer Chemoprevention with Inhaled Corticosteroids? Am J Respir Crit Care Med，2007，176：1169.
6. Buring JE，Hennekens CH.beta-carotene and cancer chemoprevention.J Cell Biochem Suppl， 1995，22：226-230.

Chinese Journal of Respiratory and Critical Care Medicine

Lung Cancer Chemoprevention with Inhaled Corticosteroids?

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