• Department of Respiratory Diseases,Nanjing General Hospital of Nanjing Command,Nanjing University Clinical School of Medicine.Nanjing,Jiangsu,210002,China Corresponding author : SONG Yong ,E-mail :yong_song6310@yahoo.com;
SONG Yong, Email: yong_song6310@yahoo.com
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Objective  To study the p-mammalian target of rapamyein(p-roTOR)expression and its prognostic significance in non-small cell lung cancer(NSCLC).Methods  Immunohistochemical staining of EnVision was applied to investigate the expression of p-roTOR in lung specimens from 59 cases with NSCLC and 10 cases with benign pulmonary diseases(3 pulmonary tuberculosises and 7 inflammatory pseudotumors 1.Results  The positive rate of p-mTOR was 40.7% in NSCLC which was significantly higher than that in the benign pulmonary diseases(x =6.237,P=0.013).The expression of p-mTOR was closely correlated with age,sex and pTNM stage.Kaplan-Meire survival analysis revealed that the expression of p-mTOR was not correlated significantly with survival days(Log rank test P =0.055).Conclusion  P-mTOR might be a biomark for differential diagnosis of malignant lung disease,but has poor prognostic value.

Citation: LIU Hongbing,SONG Yong,WU Ying. The expression of p-mammalian target of rapamycin in non-small-cell lung cancer and its prognostic significance. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(5): 354-357. doi: Copy

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