Standrdizing；Diagnosis；Treatment；Sleep Apnea-hypopnea Syndrome Associated Hypertension_Chinese Journal of Respiratory and Critical Care Medicine

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陈宝元 ¹ , 何权瀛 ²

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Standrdizing the Diagnosis and Treatment of Sleep Apnea-hypopnea Syndrome Associated Hypertension

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由于高血压的高患病率与高致残致死率, 已经成为我国重点防治的心血管疾病和社会普遍关注的重大公共卫生问题之一。大量流行病学、临床和基础研究已证实睡眠呼吸暂停低通气综合征( sleep apnea-hypopnea syndrome, SAHS) 与高血压发病和疗效关系密切[ 1-8 ] , 是高血压发生的主要病因之一, 由此“睡眠呼吸暂停相关性高血压”一词便应运而生[ 9-1 0] , 它是指由SAHS 引发和加重的高血压。本期刊载的“阻塞性睡眠呼吸暂停相关性高血压临床诊断和治疗专家共识”( 以下简称共识) , 为睡眠呼吸暂停相关性高血压的诊治提供了规范性的指导意见, 对推动我国该领域的防治水平有重要作用。我们期望“共识”能为读者认识和防治睡眠呼吸暂停相关性高血压提供必要的指导和帮助, 使我国为数众多的睡眠呼吸暂停相关性高血压患者得到规范的诊治。

Citation： 陈宝元,何权瀛. Standrdizing；Diagnosis；Treatment；Sleep Apnea-hypopnea Syndrome Associated Hypertension. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(5): 433-434. doi: Copy

1.	Guilleminault C, Eldridge F, Dement WC. Insomnia with sleep apnea: a new syndrome. Science, 1973, 181: 856 -858.
2.	Tilkian AG, Guilleminault C, Schroeder JS, et al. Hemodynamics in sleep-induced apnea. Studies during wakefulness and sleep. Ann Intern Med, 1976, 85: 714 -719.
3.	Kales A, Bixler EO, Cadieux RJ, et al. Sleep apnoea in a hypertensive population. Lancet, 1984, 2 : 1005-1008.
4.	Lavie P, Ben-Yosef R, Rubin AE, et al. Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J,1984, 108 : 373-376.
5.	Young T, Peppard PE, Palta M, et al. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med, 1997, 157 : 1746 -1752 .
6.	Logan AG, Perlikowski SM, Mente A, et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens, 2001, 19: 2271-2277.
7.	Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med, 2000 , 342: 1378-1384.
8.	Kim J, Yi H, Shin KR, et al. Snoring as an independent risk factor for hypertension in the nonobese population: the Korean Health and Genome Study. Am J Hypertens, 2007, 20: 819-824 .
9.	Fletcher EC. Invited review: Physiological consequences of intermittent hypoxia: systemic blood pressure. J Appl Physiol, 2001,90: 1600-1605.
10.	Weiss JW, Liu MD, Huang J. Physiological basis for a causal relationship of obstructive sleep apnea to hypertension. Exp Physiol,2007, 92: 21 -26 .
11.	Bazzano LA, Khan Z, Reynolds K, et al. Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea. Hypertension, 2007, 50: 417-23.
12.	Alajmi M, Mulgrew AT, Fox J, et al. Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea hypopnea: a meta-analysis of randomizedcontrolled trials. Lung, 2007, 185 : 67-72.
13.	Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung,and Blood Institute Joint National Committee on Prevention,Detection, Evaluation, and Treatment of High Blood Pressure;National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA, 2003, 289: 2560-2572.
14.	Young T, Palta M, Dempsey J, et al. The occurrence of sleepdisordered breathing among middle-aged adults. N Engl J Med,1993, 29, 328: 1230-1235.
15.	He J, Kryger MH, Zorick FJ, et al. Mortality and apnea index in obstructive sleep apnea. Chest, 1988, 94: 9-14.
16.	Somers VK, White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association /American College of Cardiology Foundation Scientific Statement from theAmerican Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing.J Am Coll Cardiol, 2008, 52: 686-717 .
17.	中华医学会呼吸病学分会睡眠呼吸疾病学组. 睡眠呼吸暂停人群高血压患病率的多中心研究. 中华结核和呼吸杂志, 2007 ,30: 894-897 .

1. Guilleminault C, Eldridge F, Dement WC. Insomnia with sleep apnea: a new syndrome. Science, 1973, 181: 856 -858.
2. Tilkian AG, Guilleminault C, Schroeder JS, et al. Hemodynamics in sleep-induced apnea. Studies during wakefulness and sleep. Ann Intern Med, 1976, 85: 714 -719.
3. Kales A, Bixler EO, Cadieux RJ, et al. Sleep apnoea in a hypertensive population. Lancet, 1984, 2 : 1005-1008.
4. Lavie P, Ben-Yosef R, Rubin AE, et al. Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J,1984, 108 : 373-376.
5. Young T, Peppard PE, Palta M, et al. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med, 1997, 157 : 1746 -1752 .
6. Logan AG, Perlikowski SM, Mente A, et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens, 2001, 19: 2271-2277.
7. Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med, 2000 , 342: 1378-1384.
8. Kim J, Yi H, Shin KR, et al. Snoring as an independent risk factor for hypertension in the nonobese population: the Korean Health and Genome Study. Am J Hypertens, 2007, 20: 819-824 .
9. Fletcher EC. Invited review: Physiological consequences of intermittent hypoxia: systemic blood pressure. J Appl Physiol, 2001,90: 1600-1605.
10. Weiss JW, Liu MD, Huang J. Physiological basis for a causal relationship of obstructive sleep apnea to hypertension. Exp Physiol,2007, 92: 21 -26 .
11. Bazzano LA, Khan Z, Reynolds K, et al. Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea. Hypertension, 2007, 50: 417-23.
12. Alajmi M, Mulgrew AT, Fox J, et al. Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea hypopnea: a meta-analysis of randomizedcontrolled trials. Lung, 2007, 185 : 67-72.
13. Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung,and Blood Institute Joint National Committee on Prevention,Detection, Evaluation, and Treatment of High Blood Pressure;National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA, 2003, 289: 2560-2572.
14. Young T, Palta M, Dempsey J, et al. The occurrence of sleepdisordered breathing among middle-aged adults. N Engl J Med,1993, 29, 328: 1230-1235.
15. He J, Kryger MH, Zorick FJ, et al. Mortality and apnea index in obstructive sleep apnea. Chest, 1988, 94: 9-14.
16. Somers VK, White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association /American College of Cardiology Foundation Scientific Statement from theAmerican Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing.J Am Coll Cardiol, 2008, 52: 686-717 .
17. 中华医学会呼吸病学分会睡眠呼吸疾病学组. 睡眠呼吸暂停人群高血压患病率的多中心研究. 中华结核和呼吸杂志, 2007 ,30: 894-897 .

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Standrdizing；Diagnosis；Treatment；Sleep Apnea-hypopnea Syndrome Associated Hypertension

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