- Department of Hepatobiliaropancreatic Surgery,Affiliated Hospital of Zunyi Medical College,Zunyi 563003,Guizhou Province,China;
Objective To explore the early prevention measures of severe acute pancreatitis (SAP) complicated with infection.
Methods The foreign and native related literatures of SAP complicated with infection in recent 10 years
were retrieved, and the effect of sooner measures for SAP complicated with infection were discussed.
Results It was beneficial to reduce the incidence of infection and improve the outcome in SAP by using antibiotics of apt through the blood-pancreatic barrier, using proton pump inhibitor properly, and using enteral nutrition, hemofiltration, and hyperbaric oxygen as soon as possible, and then combined with traditional Chinese medicine.
Conclusions SAP complicated with infection is the one of the main reasons of death. It is a must to take effective and comprehensive measures in the early stage in order to reduce the rate of infection. However, there are several unclear problems to probe in the future on this issue.
Citation: WEI Wei,DUI Danhua. Early Prevention of Severe Acute Pancreatitis Complicated with Infection. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(6): 697-703. doi: Copy
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- 7. Wu BU, Johannes RS, Kurtz S, et al. The impact of hospital-acquired infection on outcome in acute pancreatitis [J]. Gastroenterology, 2008, 135(3):816-820.
- 8. Su MS, Lin MH, Zhao QH, et al. Clinical study of distribution and drug resistance of pathogens in patients with severe acute pancr-eatitis[J]. Chin Med J (Engl), 2012, 125(10):1772-1776.
- 9. Wittau M, Mayer B, Scheele J, et al. Systematic review and meta-analysis of antibiotic prophylaxis in severe acute pancreatitis[J]. Scand J Gastroenterol, 2011, 46(3):261-270.
- 10. Ignatavicius P, Vitkauskiene A, Pundzius J, et al. Effects of prophylactic antibiotics in acute pancreatitis[J]. HPB (Oxford), 2012, 14(6):396-402.
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- 28. Marik PE. What is the best way to feed patients with pancreatitis?[J]. Curr Opin Crit Care, 2009, 15(2):131-138.
- 29. Xue P, Deng LH, Xia Q, et al. Impact of alanyl-glutaminedipeptide on severe acute pancreatitis in early stage[J]. World J Gastroenterol, 2008, 14(3):474-478.
- 30. Zou XP, Chen M, Wei W, et al. Effects of enteral immunonutritionon the maintenance of gut barrier function and immune function in pigs with severe acute pancreatitis[J]. JPEN J Parenter Enteral Nutr, 2010, 34(5):554-566.
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- 40. Sun S, Yang K, He X, et al. Probiotics in patients with severe acute pancreatitis:a meta-analysis[J]. Langenbecks Arch Surg, 2009, 394(1):171-177.
- 41. Zhang MM, Cheng JQ, Lu YR, et al. Use of pre-, pro- and synb-iotics in patients with acute pancreatitis:a meta-analysis[J]. World J Gastroenterol, 2010, 16(31):3970-3978.
- 42. Petrov MS, Loveday BP, Pylypchuk RD, et al. Systematic reviewand meta-analysis of enteral nutrition formulations in acute pancr-eatitis[J]. Br J Surg, 2009, 96(11):1243-1252.
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- 44. Zhang Z, Wang Y, Dong M, et al. Oxymatrine amelioratesL-arginine-induced acute pancreatitis in rats[J]. Inflammation, 2012, 35(2):605-613.
- 45. Wang G, Sun B, Zhu H, et al. Protective effects of emodin combined with danshensu on experimental severe acute pancreatitis[J]. Inflamm Res, 2010, 59(6):479-488.
- 46. Zhang XP, Wang C, Wu DJ, et al. Protective effects of ligustrazine,kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis[J]. Methods Find Exp Clin Pharmacol, 2011, 32(9):631-644.
- 47. Jha RK, Ma Q, Lei Z, et al. Resveratrol ameliorates the delete-rious effect of severe acute pancreatitis[J]. Cell Biochem Biophys,.
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