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动脉导管未闭合并重度肺动脉高压患者的介入与外科治疗

目的 探讨动脉导管未闭(PDA)合并重度肺动脉高压(PH)患者外科手术治疗与介入封堵治疗的适应证和治疗效果。 方法 回顾分析1998年5月至2008年5月我科收治的30例PDA患者的临床资料，其中男14例，女16例；年龄14～41岁，平均年龄25.8岁。18例行外科手术治疗，12例行介入封堵治疗。 结果 经外科手术和介入封堵治疗患者术后即刻的肺动脉收缩压(608±120 mm Hg vs. 100.2±14.2 mm Hg; 60.3±11.6 mm Hg vs. 108.4±17.6 mm Hg)和平均肺动脉压(401±98 mm Hg vs. 76.1±11.3 mm Hg; 40.2±10.5 mm Hg vs. 79.5±13.6 mm Hg)均较术前明显降低（Plt;0.05）。术后4例手术患者中有2例出现声音嘶哑，2例残余分流；介入封堵治疗患者术后未出现明显并发症。随访29例，随访时间3个月~2年；1例失访。随访期间患者无明显胸闷、气促等，超声心动图检查大动脉水平未探及残余分流，1例术前伴有心房颤动的患者在封堵术后2个月时猝死，死亡原因不明。28例患者术后90 d复查超声心动图提示：肺动脉收缩压均较术前明显降低（Plt;0.05），两种治疗方法的疗效差异无统计学意义（Pgt;0.05）。 结论 介入封堵治疗PDA合并重度PH的患者与外科手术治疗相比较具有创伤小、风险小、并发症少和恢复快等优点，尤其是介入封堵治疗可行试验性封堵，对鉴别动力性和阻力性PH具有不可替代的优越性。但一些特殊类型的PDA患者仍需外科手术治疗。

腋下小切口经胸膜外结扎动脉导管治疗动脉导管未闭20例

不同杂交方式治疗累及弓部的主动脉夹层

目的　探讨不宜单独行腔内隔绝治疗、累及弓部的主动脉夹层杂交手术治疗方法及其疗效。　方法　回顾性分析2008年11月至2011年8月成都军区总医院15例累及弓部的主动脉夹层患者行杂交手术治疗的临床资料，其中男10例，女5例；年龄51～72 （58.2±7.2）岁。Stanford A型主动脉夹层4例，B型主动脉夹层11例，病变均累及主动脉弓。采用胸骨正中切口或加颈部切口行升主动脉至头臂动脉旁路移植、单纯颈部切口行头臂动脉间旁路移植，然后行股动脉切口逆行主动脉腔内覆膜支架植入。术后即刻行数字减影血管造影（DSA），术后3个月、术后1年和2年分别随访CT造影资料，观察支架和人工血管通畅情况。　结果　所有患者均成功完成手术，并植入覆膜支架。术中血管造影证实支架植入定位准确，支架无明显内漏和移位。主动脉夹层真腔血流恢复正常，旁路血管血流通畅，围术期无死亡和严重并发症发生。随访15例，随访时间3～20 （12.0±4.1）个月，所有患者均生存，恢复正常生活。术后3个月及术后1年、2年复查主动脉增强CT示：支架无移位和内漏，支架内及人工血管旁路血流通畅，未见脑部和肢体缺血征象。　结论　累及弓部的主动脉夹层可根据受累部位和程度采用不同的杂交手术方法，安全、有效，能明显减轻患者的创伤和痛苦，该方法扩大了介入覆膜支架腔内治疗的适应证，但远期疗效有待进一步观察。

Diaphragm Plication for the Treatment of Diaphragmatic Paralysis in Infants after Surgical Correction for Congenital Heart Diseases

ObjectiveTo evaluate clinical outcomes of diaphragm plication for the treatment of diaphragmatic paralysis (DP) in infants after surgical correction for congenital heart diseases. MethodsClinical data of 13 infants who had DP after surgical correction for congenital heart diseases from December 2009 to December 2012 were retrospectively analyzed. There were 5 male and 8 female patients with their age of 35 days-11 months (6.6±3.2 months) and body weight of 3.5-9.6 (6.2±1.8) kg. Diaphragm plication was performed 19.08±4.29 days after open heart surgery. All the patients were not able to wean from mechanical ventilation,or were repeatedly reintubated because of severe respiratory failure after extubation. All the 13 patients received diaphragm plication for singleor double-sided DP. ResultsTwo patients had ventilator associated pneumonia (15.4%) including 1 patient with positive sputum cultures for Acinetobacter baumannii but negative blood culture. Another patient who had double-sided DP after surgical correction for tetralogy of Fallot with pulmonary atresia underwent double-sided diaphragm plication and later died of multiple organ dysfunction syndrome,whose sputum and blood cultures were both positive for Pseudomonas aeruginosa on the 11th day after double-sided diaphragm plication. Chest X-ray of all the patients showed plicated diaphragm in normal position after diaphragm plication. The average time from diaphragm plication to extubation was 5.38±3.09 days. After diaphragm plication,arterial partial pressures of oxygen (PaO2) significantly increased (90.22±8.47 mm Hg vs. 80.69±6.72 mm Hg,P<0.05) and arterial partial pressures of carbon dioxide (PaCO2) significantly decreased (39.87±6.31 mm Hg vs. 56.38±7.19 mm Hg,P<0.05). Twelve patients were followed up for 24 months after discharge. During follow-up,1 patient who received double-sided diaphragm plication had 2 episodes of pneumonia within 6 months after discharge. Respiratory function of all the other patients was normal. All the patients were in NYHA class Ⅰ-Ⅱ. ConclusionDiaphragm plication is a safe,easy and effective treatment to increase survival rate and decrease the incidence of hospital-acquired infection for infants who have DP and are unable to wean from mechanical ventilation after surgical correction for congenital heart diseases.