Objective To analyze the international hotspots of study in age-related macular degeneration (AMD) in recent years. Methods Articles related to AMD that appeared during period January 2002-December 2010 from Pubmed database were quantitatively analyzed by software of BICOMS. PASW 18.0 statistical software used to cluster high frequency keywords of published articles. Clustering relationships of high frequency hot topics were identified. Results A total of 8529 AMD related articles were retrieved. The number of published articles in 2009 was 2.45 times greater than that of published articles in 2002. Six thousand five hundred and fourteen AMD related articles were published in the United States, England and Germany, which accounted for 76.37% of worldwide total. Fifty-two high frequency keywords were analyzed. They were clustered into 6 categories, which were identified as physiological/genetics, etiology and prevention and control, pathology and tomography and other diagnostic techniques, surgical therapy, drug therapy and photochemical therapy, and drug/laser therapy. Conclusions Recently, more attention has been paid to AMD, and the published AMD related articles has rapidly increased. The United States and European countries occupy the dominant position for the number of published AMD related articles. The international main research focus included 6 fields: basic research in AMD, etiology, pathology and diagnostic techniques, AMD prevention and control, surgery/drugs/laser and photochemical treatment of AMD.
Objective To analyze and reveal the domestic and abroad studies on polypoidal choroidal vasculopathy (PCV) by bibliometric. Methods Foreign articles were searched from American Institute of Scientific Information online database of web of science (WOS) database, Chinese articles were searched from China National Knowledge Infrastructure (CNKI) database. The age distribution, national and regional, funding agency and citation of the PCV literatures published before December 31 2012 were analyzed by software Bibexcel and SPSS 17.0. Results Totally 696 literatures were analyzed, including 440 foreign literatures and 256 Chinese literatures. The numbers of foreign literatures were gradually increased since 2000, significantly after 2007, reached the maximum at 2011. The literatures were mainly in English, the number of the literatures of China ranked 4th of all countries. The National Natural Science Foundation of China ranked No.5 of funding agency. Citations gradually increased since 2000, increased significantly after 2008; there were 30 highfrequency subjects, and hot topics were clustered into 5 categories: treatment of PCV, genetics studies of PCV, detection, diagnosis and epidemiology of PCV, relationships between PCV and macular degeneration, related cytokine of PCV. Chinese literatures increased since 2000, significantly after 2006, and reached the maximum at 2010; there were 15 literatures supported by National Natural Science Foundation of China; Citation of Chinese literatures gradually increased since 2001, and reached the maximum at 2012. There were 30 highfrequency subjects, and hot topics were clustered into 5 categories: genetics and cytokine studies of PCV, detection and diagnosis of PCV, treatment of PCV, PCV and macular diseases, PCV and vitreous hemorrhage. Conclusions Literatures of PCV were gradually increased since 2000, abroad and domestic literatures of PCV reached maximum at 2011 and 2010 respectively. The abroad research of PCV focuses on 5 categories: treatment of PCV, genetics studies of PCV, detection, diagnosis and epidemiology of PCV, relationships between PCV and macular degeneration, related cytokine of PCV. The domestic research focuses on genetics and cytokine studies of PCV, detection and diagnosis of PCV, treatment of PCV, PCV and macular diseases, PCV and vitreous hemorrhage.