【摘要】 目的 评价简化肾脏病膳食改良试验（MDRDa）方程以及国内两个改良MDRD方程（中国方程1、2）预测中国慢性肾脏病患者肾小球滤过率（glomerular filtration rate，GFR）的适用性。 方法 选择2008年1-12月住院慢性肾病患者250例，用99mTc-DTPA肾动态显像法测定GFR（sGFR），同时测定血清肌酐、尿素氮，根据年龄和性别分别用简化MDRD方程、中国方程1和中国方程2预测GFR，即eGFRa （简化MDRD方程）、eGFR1 （中国方程1）和eGFR2（中国方程2），以sGFR为参考值，将估计的eGFRs进行比较。 结果 各方程eGFRs与sGFR之间呈显著相关关系。其中中国方程2的估算eGFR2与sGFR具有良好的一致性，总体偏差最小，准确性最高。 结论 中国方程2优于简化MDRD方程和中国方程1，可用于中国慢性肾病人群eGFR的计算。【Abstract】 Objective To evaluate the applicability of three equations for glomerular filtration rate (GFR) in Chinese patients with chronic kidney disease (CKD). Methods A total of 250 patients with CKD which were diagnosed according to K/DAQI guidelines between January and December 2008 were selected. GFR were estimated with Chinese equation 1 (eGFR1), Chinese equation 2 (eGFR2) and abbreviated MDRD (eGFRa) separately, and the results were compared with that of 99mTc-DTPA(sGFR). Results The eGFRs of the three equations were correlated significantly with sGFR. Chinese equation 2 seemed to be the best; eGFR2 showed less bias and higher accuracy than other equations. Conclusion Chinese equation 2 for estimation of GFR may be more accurate in Chinese CKD patients.