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find Keyword "中西医结合疗法" 2 results
  • Quality Assessment of the Clinical Studies on Randomized Controlled Trials of Chinese Herb Medicineand Chemotherapy in the Treatment of Hepatocellular Carcinoma

    目的:对中药配合肝动脉栓塞化疗(Transcatheter Arterial Chemoembolization,TACE)辅助治疗原发性肝癌随机对照试验(Randomized controlled trial,RCT)文献进行评价。方法:对国内外公开发表的有关中药配合TACE辅助治疗原发性肝癌的随机对照试验进行检索,检索数据库包括Cochrane图书馆临床对照试验库,MEDLINE、CBM、CNKI和VIP电子数据库。手工检索中文相关期刊以及附加检索相关会议论文集。质量评价采用Jadad评分量表、CONSORT标准和其他自拟评价指标进行分析。结果:共纳入103篇RCTs,其中Jadad评分得5分有1篇文献,3分1篇,2分10篇,71篇1分,其余20篇均为0分,有3篇文献报告了分配隐藏。按CONSORT标准,仅1篇(0.97%)RCT描述了如何产生随机顺序,没有RCT报道如何执行随机,其中1篇为半随机,有1篇(0.97%)RCT采用安慰剂对照,有54篇(52.43%)报道了终点指标,分别各有2篇(1.94%)报道了双盲和单盲,14篇(1359%)进行了具体统计量计算,54篇(52.43%)提供了随访记录,7篇(6.80%)报道了阴性结果,16篇(15.53%)报道不良事件,仅有1篇(0.97%)进行样本含量计算与意向性分析(ITT),有2篇(1.94%)进行分层分析,属于多中心的仅有1篇(0.97%),均未进行伦理审批和知情同意。描述了中医证型的有3篇(2.91%)。结论:目前中药配合TACE辅助治疗原发性肝癌临床研究的方法学和报告质量尚低,且多数RCT可能存在选择性偏倚和测量性偏倚,期待更多高质量的随机双盲对照试验为临床应用提供可靠的依据。

    Release date:2016-09-08 10:14 Export PDF Favorites Scan
  • Methodological Quality Assessment of Systematic Reviews and Meta-analysis in Fields of Integrated Chinese-western Therapy for Non-small Cell Lung Cancer

    ObjectiveTo evaluate the methodological quality of systematic reviews and meta-analysis (SRs/MAs) in fields of integrated Chinese-western therapy for non-small cell lung cancer (NSCLC). MethodsSRs/MAs in fields of integrated Chinese-western therapy for NSCLC were searched inPubMed, EMbase, CBM, CNKI, VIP and WanFang Data from inception to July 10th, 2016. We also handsearched relevant journals such as Chin J Evid-based Med and reference of included studies, and tried to find the grey literature for additional studies. Two researchers independently screened literature and extracted data. Then methodological quality of included SRs/MAs were evaluated by AMSTAR scale. ResultsA total of 53 SRs/MAs were included, the highest and lowest scores of methodological quality were 9 and 1, respectively. The average score was 5.98±1.50. Results on the qualities of methodology or evaluation showed that 46 SRs/MAs (88.68%) was rated as moderate and 6 (11.32%) as low. The main problems were found in such areas as preliminary design scheme, literature searching, a list of included and excluded studies, etc.. ConclusionThe methodology of SRs/MAs in fields of integrated Chinese-western therapy for NSCLC have quality problems at different levels, further improvement should be expected.

    Release date:2016-10-26 01:44 Export PDF Favorites Scan
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