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find Keyword "临床价值" 15 results
  • 互联网医疗在癫痫患儿中的临床价值探讨

    通过对山东大学附属儿童医院癫痫中心远程会诊中心三级诊疗服务体系的应用情况进行总结、分析,探讨互联网医疗在癫痫患儿诊治及管理中的应用价值。利用癫痫与脑电远程会诊云平台为核心,上联三级癫痫中心,下联基层医疗机构,促进对各级癫痫中心脑电图检查项目技术操作及报告的同质化管理,实现跨区域脑电诊断中心专家资源的共享,促进优质医疗资源的输出,有助于患者得到更快速、准确的诊疗,通过互动交流帮助基层医疗机构全面性提高癫痫诊治能力。

    Release date:2023-10-25 09:09 Export PDF Favorites Scan
  • CRP in the Diagnosis of Acute Pancreatitis Value

    摘要:目的:动态监测急性胰腺炎(AP)患者外周血C反应蛋白(CRP)水平,探讨CRP对AP的早期诊断与病情评估的参考价值。方法:分别检测75例SAP患者和75例 MAP患者入院后第1、3、5、7、9天外周血CRP水平,并进行分析比较。结果: MAP组患者CRP高峰值出现在住院第3天,第7天开始下降,14天后恢复正常。而SAP组患者住院第1天即可出现CRP显著增高,且下降速度缓慢,在后期CRP仍可维持在一个较高水平。入院第1天,SAP组血清CRP水平均显著高于MAP组(Plt;0.01)。轻症与重症组(无并发症或有并发症)之间患者血清CRP水平差异均有高度显著性(Plt;0.01)。结论: 动态监测CRP可作为AP早期诊断、疾病严重程度评估及预后判断的一个独立的衡量指标,值得临床推广应用。Abstract: Objective: To dynamic monitoring of acute pancreatitis (AP) in patients with Creactive protein (CRP) levels, CRP on the AP to explore the early diagnosis and prognostic evaluation of the reference value. Methods: 75 cases of SAP patients were examined and 75 patients with mild acute pancreatitis (MAP) after admission in patients with CRP levels in peripheral blood 1,3,5,7,9 days, and conduct analysis and comparison of. Results:MAP peak value of CRP in patients in hospital the first 3 days, 7 day drop in 14 days after return to normal. The SAP Group 1st day of hospitalization was significantly higher CRP can occur, and the rate of decline is slow, in the latter part of CRP can be maintained at a high level. Admission day 1, SAP serum levels of CRP were significantly higher than the MAP group (Plt;0.01). Between mild and severe group, no complications and complications in patients with serum CRP levels of SAP differences were highly significant (Plt;0.01). Conclusion:Dynamic monitoring of CRP can be used as AP early diagnosis, disease severity assessment and prognosis of an independent measure worthy of clinical application.

    Release date:2016-09-08 10:12 Export PDF Favorites Scan
  • Clinical Value of Transthoracic Echocardiography in the Diagnosis of Infective Endocarditis

    ObjectiveTo explore the clinical value of transthoracic echocardiography (TTE) in the diagnosis of infective endocarditis. MethodsWe retrospectively analyzed the transthoracic echocardiogram in 35 patients with infective endocarditis confirmed between September 2003 and September 2013. Patients underwent routine heart scan in all sections to measure sizes of all chambers and cardiac function, observe morphologies, activities and functions of all valves and ventricular walls, and diagnose whether underlying heart diseases exist, focusing on intracardiac vegetations and their distributions, morphologies, sizes, numbers, echoes and activities, and a full analysis of the blood culture findings was also conducted. ResultsOf the 35 patients undergoing initial TTE, 29 were positive, and 6 were negative (2 positive and 4 negative in the reexamination one week later). Vegetations were found in the mitral valve (8/35), aortic valve (15/35), tricuspid valve (5/35), pulmonary valve (1/35), pulmonary arterial wall (1/35) and right ventricle (1/35), respectively. There were 29 (8 and 21 with congenital and acquired heart diseases, respectively) and 6 patients with and without underlying heart diseases, respectively. Of the 35 blood cultures, 33 were positive and 2 were negative. ConclusionsTTE is rapid and accurate for early diagnosis of infective endocarditis, precise localization and rough quantification of vegetations, determination of whether valve damage occurs and what its severity is, and detection of whether complications exist. It is valuable for early diagnosis, treatment, follow-up and prognosis judgment.

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  • Research progress of novel serum marker Golgi protein 73 in clinical diagnosis and treatment of chronic hepatitis B

    Serum marker Golgi protein 73 (GP73) is a type Ⅱ integral membrane protein located in cellular Golgi apparatus. GP73 not only processes proteins, but also participates in cell differentiation, intercellular signaling, and apoptosis. With the development of proteomics technology, GP73 has been used as a novel serum marker for detecting liver diseases. This article reviews the research progress of GP73 in the clinical diagnosis value and prognosis prediction of chronic hepatitis B in recent years, in order to provide new ideas for the diagnosis and treatment of patients with chronic hepatitis B.

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  • 腹腔镜联合胆道镜在肝外胆管结石再次手术中的应用价值

    目的 分析腹腔镜联合胆道镜在肝外胆管结石再次手术中的临床应用效果。 方法 回顾性分析东莞市塘厦医院于 2011 年 1 月至 2016 年 1 月期间收治的 53 例肝外胆管结石患者的临床资料,所有患者采用腹腔镜联合胆道镜进行再次手术取石。 结果 53 例患者的手术成功率为 92.5%(49/53);手术时间为 95~286 min、(165.37±41.43)min;术中出血量为 9~247 mL、(34±10)mL;术后下床活动时间为 21~43 h、(26.3±1.7)h;术后恢复进食时间为 1~6 d、(2.5±1.2)d;腹腔引流管拔出时间为 3~6 d、(3.5±1.8)d;术后住院时间为 4~13 d、(7.0±2.7)d。44 例患者行腹腔镜联合胆道镜取石+激光碎石+T 管引流,5 例行腹腔镜联合胆道镜取石+激光碎石+胆总管一期缝合,4 例患者中转开腹手术。术后发生胆汁漏 1 例,腹壁操作孔感染 1 例。术后 53 例患者均获访,随访时间为 2~29 个月、(15.3±2.1)个月。其中 6 例患者于术后 2~3 个月发现胆管仍有残余结石,经窦道用胆道镜取净结石。随访期间无结石复发患者。 结论 腹腔镜联合胆道镜在肝外胆管结石再次手术中的临床疗效确切,具有创伤小、恢复快、并发症少及成功率高的优点,临床应用前景广阔。

    Release date:2017-08-11 04:10 Export PDF Favorites Scan
  • Clinical Value of Serum Levels of Insulin Growth Factor-1 and Glial Fibrillary Acidic Protein in Glioma Grading and Prognosis Assessment

    目的 通过检测脑胶质瘤患者血清中胰岛素生长因子-1(IGF-1)和胶质纤维酸性蛋白(GFAP)的表达,探讨其与胶质瘤分级及预后评估的关系。 方法 2010年12月-2011年11月,采用双抗体一步夹心法分别测定A、B两组共40例不同级别脑胶质瘤患者术前、术后血清中IGF-1和GFAP浓度。 结果 高级别胶质瘤患者组血清中IGF-1浓度显著高于低级别胶质瘤组(P=0.009 0);血清GFAP浓度显著低于低级别胶质瘤组(P<0.000 1)。经手术治疗后且疗效评价为有效的胶质瘤患者,其血清中IGF-1、GFAP浓度较术前水平显著下降(P<0.001 0)。结论 IGF-1、GFAP是两种较好的脑胶质瘤血清标志物,在其分级及预后评估中具有重要的临床应用价值。

    Release date:2021-06-23 07:35 Export PDF Favorites Scan
  • CT Manifestation and Clinical Significance of Gastrointestinal Tract Involvement in Acute Pancreatitis

    Objective To investigate the CT manifestation and clinical significance of the gastrointestinal tract involvement in acute pancreatitis (AP). Methods Two hundreds CT scans in 131 patients with acute pancreatitis between Jan. 1, 2009 and Jun. 30, 2009 were included into the study. Two radiologists analyzed the images retrospectively, paying attention to the CT features of the gastrointestinal tract involvement, such as the style, distribution, and so on. The correlation between gastrointestinal tract involvement and CT severity index, clinical severity grading, and turnover of acute pancreatitis were studied using a SPSS 14.0 for windows statistics software. Results The CT images in 109 (83.2%) patients showed gastrointestinal tract involvement, which distributing mainly stomach, duodenum, jejunum, and transverse colon, and showing mainly the gastrointestinal tract wall thickening and distension. The gastrointestinal tract involvement had positive correlation with CT severity index, clinical severity grading, and turnover of acute pancreatitis (r=0.689, P=0.000; r=0.584, P=0.000; r=0.346, P=0.000). Conclusions The gastrointestinal tract involvement is common complication in acute pancreatitis and concerns with severity and prognosis of the disease. As other extrapancreatic organs involvement, the gastrointestinal tract involvement has important value for severity assessment, prognosis evaluation, and therapeutic effect monitoring of acute pancreatitis.

    Release date:2016-09-08 10:54 Export PDF Favorites Scan
  • Construction and evaluation of the evidence chain for the efficacy of traditional Chinese medicine

    With the advancement of modern research in traditional Chinese medicine (TCM), evidence regarding the clinical efficacy and mechanisms of action of TCM has rapidly accumulated. However, due to a lack of methodological safeguards, the disconnection between clinical and basic research in TCM has become increasingly prominent, making it difficult to form an evidence chain that supports the scientific value of TCM in a manner that is "clear and understandable". Therefore, it is necessary to develop methods for the translation and integration of clinical and basic research evidence oriented towards clinical value, to form a reliable evidence chain that can further discover patterns, confirm efficacy, and highlight advantages. This article discusses the construction and evaluation methods of the evidence chain for the efficacy of TCM, aiming to provide theoretical and methodological references for related work.

    Release date:2025-04-28 03:55 Export PDF Favorites Scan
  • Key considerations for using real-world data to evaluate the clinical and economic value of drugs

    With the acceleration of global innovative drug development, selecting safe, effective, and cost-effective products from numerous drugs has posed new challenges for the decision-making process of medical insurance drug access and dynamic updating of insurance directory. Real-world data (RWD) provides a new perspective for evaluation of clinical and economic value of drugs, but there are still uncertainties regarding the scope, quality standards, and evidence categories of RWD that can be used. Based on the current status of domestic and international RWD supporting the assessment of the clinical and economic value of drugs, this paper, in collaboration with national RWD and healthcare experts, has developed the key considerations for using real-world data to evaluate the clinical and economic value of drugs. This paper first clarifies the scope of RWD that can be used to evaluate the clinical and economic value of drugs evaluate; secondly, provides specific requirements and guidance on data attribution, data governance, and quality standards for RWD; finally, summarizes the evidence categories of RWD supporting evaluate the clinical and economic value of drugs evaluate.

    Release date:2024-06-18 09:28 Export PDF Favorites Scan
  • Key technical considerations for the evaluation of clinical value of drugs using real-world data

    Assessing the clinical value of pharmaceuticals is crucial for comprehensive evaluation in clinical practice and plays a vital role in supporting decision-making for drug supply assurance. Real-world data (RWD) offers valuable insights into the actual diagnosis and treatment processes, serving as a significant data source for evaluating the clinical demand, effectiveness, and safety of drugs. This technical guidance aims to elucidate the scope of application of RWD for the clinical value assessment of pharmaceuticals, as well as the key considerations for conducting value assessment research. These considerations include identifying the dimensions of clinical value that necessitate RWD and effectively utilizing RWD for evaluation purposes. Additionally, this guidance provides essential points for implementing pharmaceutical clinical value assessment based on real-world data, with a specific focus on study design and statistical analysis. By doing so, this guidance assists researchers in accurately comprehending and standardizing the utilization of real-world research in conducting pharmaceutical clinical research.

    Release date:2024-06-18 09:28 Export PDF Favorites Scan
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