【摘要】 目的 突破临床药物治疗学的传统教学方式，探索培养药学专业学生分析问题和解决问题能力的途径和方法。 方法 针对临床药物治疗学兼备药理学、诊断学、内科学交叉学科的特点，采用基于问题学习和病案讨论式学习模式进行教学方法的改革与探索。 结果 新的教学模式有助于激发学生的学习兴趣，帮助学生建立正确的临床药物治疗思维，取得良好的教学效果。 结论 新的教学模式优于传统教学模式。【Abstract】 Objective To explore the application of problem based learning (PBL) and case based study (CBS) in clinical pharmacotherapy. Methods The didactics was elaborately designed and the didactic reform was carried out by PBL and CBS, adopting class teaching method focused on problems. Results The new teaching style could vitalize the students’ motivation of learning and help students establish correct clinical therapeutic thoughts. It gained fine didactic effects. Conclusion The new teaching style is superior to the traditional teaching style.