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find Keyword "乙酰肝素酶" 2 results
  • 乙酰肝素酶与糖尿病肾病

    【摘要】 乙酰肝素酶(heparanase,HPA)是目前发现的哺乳动物细胞中唯一能切割细胞外基质中硫酸肝素蛋白多糖侧链的内源性糖苷酶。因其可促进肿瘤细胞的浸润和转移,还可以促进肿瘤细胞生长和微血管形成,而被视为是抗肿瘤、抗炎症的理想靶点。研究表明HPA可以降解肾小球基底膜硫酸乙酰肝素多糖侧链,造成肾小球基底膜选择性滤过蛋白质功能下降,与糖尿病肾病(diabetic nephropathy,DN)蛋白尿的产生密切相关。HPA活性的高低对糖尿病肾病的研究有着重要的意义。现将HPA与DN之间的研究进展作一综述。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • Heparanase Expression in Colorectal Cancer and Its Relationship with Clinical Prognosis

    Objective Heparanase can specifically cleave carbohydrate chains of heparan sulphate proteoglycans, which is an important component of the extracellular matrix. This study was designed to investigate the expression of heparanase in patients with colorectal cancer, and to analyze its relationships with progression of the cancer and clinical prognosis. Methods Samples were collected from 36 patients with colorectal cancers from 2003 to 2004 in Peking Union Medical College Hospital, and were embeded by Paraffin and fresh-frozened. The expression of heparanase mRNA and its protein were measured by RT-PCR and immunohistochemistry. The relationships between these expressions and the clinicopathologic information (tumor invasion, tumor differentiation, lymph node involvement, accompanying with colorectal adenoma and 2-year survival) were also evaluated. Results The expressions of heparanase mRNA in colorectal cancer (19/31, 61.3%) were significantly higher than those in normal colorectal tissues (6.5%). The overexpressions in normal tissues were positively correlated to the incidence of adenoma in patients with colorectal cancer (r=0.352, P=0.024). The result of immunohistochemistry also showed that heparanase mainly expressed in the vascular endothelium within cancer tissues and the peripheral invased region outside cancer tissues. The 2-year disease-free-survival in patients with negative heparanase expression (88.9%) was higher than that with positive heparanase expression (50.0%), but there was no significant difference (P=0.078). Conclusion Heparanase overexpressed in colorectal cancer tissues, and thus it may take a role as an indicator for the formation and prognosis of colorectal cancer.

    Release date:2016-09-08 11:49 Export PDF Favorites Scan
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