Objective To evaluate the effectiveness of exercise and rehabilitation program in improving shoulder function and quality of life for breast cancer patients after mastectomy. Method We searched the Cochrane Database of Systematic Reviews, JBI Database of Systematic Reviews, MEDLINE (1966 to 2008), EMbase (1989 to 2007), CINAHL (Cumulative Index to Nursing and Allied Health literature), CBMdisc (1978 to 2008), and CNKI (1994 to 2008) to collect randomized controlled trials (RCTs). The quality of RCTs was critically appraised and data were extracted by 3 reviewers independently. Meta-analyses were conducted for the eligible RCTs. Result Nineteen RCTs were included. Stepwise upper extremity exercise and body exercise were reported in the rehabilitation program. Nine studies indicated that the rehabilitation program significantly improved the shoulder function of breast cancer patients after mastectomy. Four studies demonstrated its effect on cardiopulmonary function and body endurance. Six RCTs proved the effect of rehabilitation program on health-related quality of life and fatigue alleviation. Conclusion Rehabilitation program consisting of stepwise upper extremity exercise and full-body exercise is effective in improving the shoulder function and enhancing the quality of life of breast cancer patients after mastectomy. It also has a positive effect in reducing fatigue for those undergoing chemotherapy or radiotherapy.
目的 探讨β —七叶皂甙钠对乳腺癌术后患侧上肢水肿的预防作用。方法 84例乳腺癌患者配对后分为实验组和对照组。对照组给予手术等常规治疗，实验组术后另给予β —七叶皂甙钠10～20 mg静脉推注，每12小时1次，连用7～10天，观察两组患者术后患侧上肢水肿的发病率。结果 对照组术后患侧上肢水肿发生率为20.93%(9/43)，实验组为4.88%(2/41)，两组之间差异有显著性意义。结论 β —七叶皂甙钠对乳腺癌术后患侧上肢水肿的发生有预防作用。