目的 探讨乳腺癌患者术后行化学疗法（化疗）期间采用集体操锻炼方式对促进术后康复的影响及效果。 方法 2010年4月－2011年4月，将90例乳腺癌术后行化疗患者，随机分为试验组和对照组（n=45），分别采用不同形式的康复训练方法锻炼患侧上肢功能，在第6个周期化疗结束时，测量比较两组患者患侧肩关节活动度及肺功能。 结果 试验组患肢肩关节活动度及肺功能明显优于对照组，差异有统计学意义（P＜0.05）。 结论 集体操运动方式结合瑜伽功，可有效提高患者的整体康复效果。
Objective To investigate the expression of claudin-1 in breast tumor tissues and the relationship of development and progress of breast neoplasm．Methods The expressions of claudin-1 in 89 cases of breast cancer and 37 benign breast diseases were tested by tissue chip technology and immunohistochemistry．The relationships of claudin-1 expression to the lymph node metastasis，TNM staging，maximum diameter of the tumor，and histology grade were statistically analyzed．Results The expression of claudin-1 in the breast cancer was significantly lower than that in the benign breast disease（χ2=19.20，P=0.000 2）．The claudin-1 expression in the patients with lymph node metastasis was significantly lower than that without lymph node metastasis （χ2=3.85，P=0.049 7）．The claudin-1 expression in the stageⅢ of TNM staging was weaker than that in the stage Ⅰ（χ2=5.29，P=0.021 4） and stage Ⅱ （χ2=7.46，P=0.006 3），respectively. There was no significant difference of the claudin-1 expression in the different maximum diameters of tumor （χ2=1.58，P=0.453 8） or histology grades （χ2=1.02，P=0.600 5），respectively．Conclusions The expression of claudin-1 might be correlated with the occurrence，development，and metastasis in breast tumor．It may be one of the potential indicator for lymph node metastasis and prognosis assessment in breast cancer．
【摘要】 目的 探讨选择性乳腺导管造影对溢液性乳腺肿瘤的鉴别诊断价值。 方法 回顾性分析2005年1月-2009年7月50例溢液性乳腺肿瘤资料，所有患者均行钼靶X线平片摄影、选择性乳腺导管造影检查及手术病理确诊。 结果 17例乳腺癌主要表现为分支导管内不规则的充盈缺损伴导管壁破坏，导管阻塞中断、断续征、潭湖状充盈等征象；33例乳腺导管内乳头状瘤主要表现为大导管内光整的充盈缺损，导管壁多无破坏，并伴有导管扩张以及扭曲。 结论 选择性乳腺导管造影对溢液性乳腺肿瘤诊断和鉴别诊断具有重要价值。【Abstract】 Objective To evaluate the value of selective mammary ductography in the diagnosis of breast tumours with nipple discharge. Methods The clinical data of 50 patients with breast tumours with nipple discharge diagnosed in our department form January 2005 to July 2009 were analyzed retrospectively. All patients were proved by molybdenum target mammography, selective mammary ductography and pathology. Results Seventeen patients with breast cancer’s galactographic features were mostly irregular intraductal defect with ductal wall breakage and ductal obstruction in the peripheral ducts; 33 patients with intraductal papilloma’s galactographic features were smooth intraductal filling defect with ductal wall integrity and ductal dilatation and torsion in the main ducts. Conclusions Selective mammary ductography is useful in diagnosis and differentiation of the breast tumours with nipple discharge.
ObjectiveTo investigate the X-ray diagnostic significance of calcification of the breast tumor without mass. MethodsMammograms of 90 cases of breast tumor without mass confirmed pathologically were retrospectively analyzed. There were 55 cases confirmed benign breast tumor, and the rest cases were breast cancer. The shape, distribution, total number, location of calcifications in the breast, and asymmetric dense of the breast were recorded and watched. Results①The X-ray findings of calcification in benign breast tumors always presented as coarse granular (31), scattered shape (35) with small number, less with the asymmetric dense of the breast (7), and the change of side with axillary lymph node (2). ②Meanwhile, fine sand-like (32), showing the cluster-like distribution (24) with larger number, with the asymmetric dense of the breast (24) and the change of side with axillary lymph node (10). Both of the differences of the calcifications (the shape, the distribution, and the total number) were statistically significant (Plt;0.05). ConclusionsThe calcifications of benign and malignant breast tumors have their unique X-ray characteristics. And there is a great value in differentiating early benign and malignant breast tumor.
Objective To summarize the progress of clinical research on triple-negative breast cancer (TNBC). Methods Domestic and international publications on the study of TNBC in recent years were collected and reviewed. Results The patients with TNBC were younger, and their prognosis was poorer. Besides operation, chemotherapy was the major therapeutic tool for them. Currently the targeted therapy for epidermal growth factor receptor and its signal conducting system was applied to clinical therapy gradually， and it might benefit the patients with TNBC. Conclusion The study on TNBC may bring a new way for therapy.
【Abstract】ObjectiveTo observe the effect of nimesulide (NIM) on DMBA-induced mammary tumors and to investigate possible mechanisms of inhibiting tumors. MethodsThe Wistar rats were randomly divided into four groups: DMBA group, NIM+DMBA group, NIM+diet group and diet group. The incidence and mean latent phase of mammary tumors were observed. The number and volume of tumors in every rat were measured. The apoptosis index and proliferation index were evaluated by TUNEL assay and PCNA immunohistochemical staining respectively.Results The latent phases of mammary tumors in NIM+DMBA group were strikingly longer than those in DBMA group 〔(115±14.8) d vs (84±15.6) d,P＜0.01〕. The incidence of mammary tumors was 69.2% in DMBA group, 46.4% in NIM+DMBA group. There was obviously decreased incidence in NIM+DMBA group (P＜0.05）. The number and the mean volume of mammary tumors in every rat in NIM+DMBA group were markedly less than DBMA group 〔（0.82±0.31） vs （1.52±0.43），（3.24±1.21） cm3 vs （6.03±1.84） cm3，P＜0.05〕. The apoptosis index was obviously higher and the proliferation index was markedly lower in NIM+DMBA group compared with DMBA group〔(42.54±13.24)% vs (18.14±6.66)%, (20.25±4.97)% vs (36.36±5.02)%, P＜0.05〕. ConclusionNIM can inhibit the development of DMBA-induced mammary tumors by inhibiting proliferation and inducing apoptosis.