ObjectiveTo study the relationship between macular pigment optical density (MPOD) and serum concentration of lutein and zeaxanthin in an adult population. MethodsTwenty patients with mild cataract and 39 healthy subjects were enrolled in this study, including 15 males and 44 females. The average age was 43.75 years. Fifty-three subjects were non-smokers and 6 male subjects were smokers. Two subjects preferred meat diet, 22 preferred meat-less diet, and 35 have balanced diet. MPOD was measured using heterochromatic flicker photometry at 0.25, 0.5, 1.0 and 1.75 degrees, and serum concentration of lutein and zeaxanthin was measured using high-performance liquid chromatography. The relationship between MPOD and serum concentration of lutein and zeaxanthin was analyzed. The differences of serum lutein and zeaxanthin between different gender, smokers and non-smokers and subjects with different dietary pattern were also analyzed. ResultsMPOD at 0.25, 0.5, 1.0 and 1.75 degrees were 0.59, 0.48, 0.34 and 0.18, and the average concentration of lutein and zeaxanthin were (0.45±0.16) μmol/L and (0.11±0.04) μmol/L respectively. Serum concentration of lutein and zeaxanthin in males were slightly higher than that in females, but it was not statistically significant (t=1.13, 0.86; P=0.27, 0.40). The differences of serum lutien and zeaxanthin between smokers and non-smokers (t=-0.15, -0.11; P=0.87, 0.91), among subjects of 3 dietary patterns groups were not statistically significant (Flutein=3.87, 4.05, 0.18; P=0.83, 0.81, 0.99. Fzeaxanthin＝0.99, 1.51, 0.52; P＝0.85, 0.68, 0.72). There was no correlation between MPOD and serum concentration of lutein (r=-0.06,-0.02,-0.07,0.03;P>0.05)and zeaxanthin(r=0.02,0.12,0.09,0.11;P>0.05). ConclusionMPOD was not statistically significantly correlated with serum concentration of lutein and zeaxanthin in the studied population.
Objective To investigate the risk factors of childhood leukaemia. Methods Questionnaire about risk factors of childhood leukaemia was devised and used. We surveyed and analyzed the relevant risk factors of 143 cases of leukaemia children in Children’s Hospital of Chongqing Medical University from May 2008 to February 2009, comparing with 108 hospitalized cases without leukaemia during the same period. The significant factors were identified by single factor analysis. Then multi-factors conditional logistic regression analysis was conducted. Results In the single factor analysis, 12 of 26 indexes were statistically significant (Plt;0.05), while in the multi-factors logistic regression analysis, there were 8 of 12 indexes with significance (Plt;0.05), which of those are frequent infection history, house decoration, family history of cancer, maternal childbearing age, and history of contact with paint, leather shoes, radiation and pesticides. Conclusion The 8 indexes as listed above are closely related to the pathogeny of leukaemia and may be the distinguished risk factors of childhood leukaemia.