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find Author "付平" 52 results
  • RhoA/Rho相关卷曲螺旋形成的蛋白激酶信号通路与慢性肾脏疾病

    【摘要】 RhoA/Rho相关卷曲螺旋形成的蛋白激酶(ROCK)信号通路是细胞内重要的信号转导通路,在慢性肾脏疾病的进展中起重要作用。肾间质纤维化是各种慢性肾脏疾病发展到终末期肾衰竭的共同途径;糖尿病肾病是继发性慢性肾脏疾病的主要病因。现就RhoA/ROCK信号通路在肾间质纤维化和糖尿病肾病发病机制中的作用作一综述。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • 糖尿病酮症酸中毒横纹肌溶解致急性肾功能衰竭一例

    【摘要】 目的 报道糖尿病酮症酸中毒(DKA)横纹肌溶解(RM)并致急性肾功能衰竭的临床诊治经验。〖HTH〗方法〖HTSS〗 2009年10月8日收治1例DKA患者,病程中出现意识障碍、RM、急性肾功能衰竭,行连续性血液净化治疗。结果 48 h后患者意识障碍恢复,血肌酸激酶下降,酸中毒纠正,治疗效果显著。结论 提高对DKA患者发生RM的认识和常规肌酶谱的动态监测,做好早期诊断以及预防极其重要,是RM合并急性肾损伤(AKI)治疗的关键,有利于提高糖尿病患者的生存率。

    Release date:2016-09-08 09:37 Export PDF Favorites Scan
  • The interpretation of KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)

    Release date:2017-08-17 10:28 Export PDF Favorites Scan
  • A brief talk about integrated management strategy of chronic kidney disease in China

    Chronic kidney disease (CKD) has been highlighted as one of the most important public health problems due to sharply climbing incidence and prevalence. To efficiently attenuate the disease burden and improve the disease management, not only active and effective treatment should be administrated, but also comprehensive follow-up nursing management with innovative and evolving spirits should be implemented. Thus dynamic changes of diseases could be acquired in time and patients are under appropriate medical instruction as soon as possible. This editorial is based on quickly developing medical big data resources and advanced internet techniques, from both aspects of patients and health care providers, briefly talking about integrated management strategy of CKD and its future development in China.

    Release date:2019-08-15 01:18 Export PDF Favorites Scan
  • 多发性骨髓瘤肾病伴神经损害一例

    Release date:2016-09-07 02:34 Export PDF Favorites Scan
  • 糖尿病肾病合并Ⅳ型肾小管性酸中毒二例

    Release date:2016-09-08 09:52 Export PDF Favorites Scan
  • 新型抗炎介质消退素的生物效应及机制

    消退素是一类具有抗炎效果的内源性多不饱和脂肪酸衍生物,可分为E类消退素、D类消退素、阿司匹林触发消退素等类型。消退素在多种组织器官的炎症中显示出较强的抗炎效果,同时还具有镇痛、抗纤维化、改善胰岛素抵抗等作用。而核因子-κB、丝裂原活化蛋白激酶、蛋白激酶B等通路可能介导上述生物效应。现就消退素的生物效应及机制的最新研究进展作一综述。

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  • The timing of continuous renal replacement therapy in acute kidney injury

    Acute kidney injury (AKI) presents as a sharp decline in renal function caused by a variety of reasons. It is a severe clinical challenge affecting multiple organs and multiple systems, with high mortality. Continuous renal replacement therapy (CRRT) plays an important role in the treatment of AKI. Limited by the lack of evidence, the timing of CRRT for AKI remains ambiguous. This article reviews the definition and grading of AKI, the indication and the timing of initiation/termination of CRRT for AKI .

    Release date:2018-07-27 09:54 Export PDF Favorites Scan
  • The interpretation of the 2017 Acute Dialysis Quality Initiative Guidelines: precision continuous renal replacement therapy

    In 2017, the Acute Dialysis Quality Initiative (ADQI) Consensus Group released a series of guidelines on the topic of "Precision Continuous Renal Replacement Therapy (CRRT)". The updated content in this guideline included four parts: patient selection and timing of CRRT, precision CRRT and solute control, precision fluid management in CRRT, and role of technology for the management of AKI in critically ill patients. This review will interpret the 2017 ADQI guidelines update in detail.

    Release date:2018-07-27 09:54 Export PDF Favorites Scan
  • Reserch progress on novel prognostic predictors of acute renal injure in intensive care unit

    Although the recent studies have concerned the pathogenesis and therapeutic strategies of acute kidney injury (AKI), the mortality of AKI is still terribly high, and it is still one of the most important death factors in the intensive care unit. There is no doubt that early verdict of AKI, is good for a more aggressive treatment and can promise an improved prognosis for AKI patients. Serum creatinine level, serving as the gold standard for diagnosis of kidney injury, cannot meet current clinical work in its sensitivity and specificity of diagnosis of early AKI. Over the past decades, researchers worked to find and verify novel AKI biomarkers, including neutrophil gelatinase associated lipocalin, interleukin-18, kidney injury molecule-1 and cystatin-C, which were proved to be the potential reliable predictor of AKI development and prognosis, and were of great importance to the early diagnosis and clinical monitoring of AKI. This paper reviews the main studies on these novel prognostic predictors of AKI over the decades and evaluates their roles and limitations in early diagnosis and clinical prognosis prediction.

    Release date:2018-07-27 09:54 Export PDF Favorites Scan
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