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find Author "何宇" 2 results
  • Preliminary Study of Correlation Between Androgen or Stathmin Expression in Patients with Triple Negative Breast Cancer and Its Clinicopathologic Factors

    Objective To explore the expressions of androgen (AR) and Stathmin in triple negative breast cancer (TNBC) and analyze the correlation between these expressions and clinicopathologic features. Methods Eighty-three patients who were diagnosed as TNBC and met the inclusion criteria from 2005 to 2009 in the Sichuan Provincial People’s Hospital were collected retrospectively. The expressions of AR and Stathmin in the TNBC tissues by using the method of EnVision immunohistochemistry. The correlation between AR or Stathmin expression and age, tumor size, lymph node status, or histological grade was analyzed by Spearman test. Results The AR and Stathmin positive expression rates in the patients with TNBC were 37.3% (31/83) and 98.8% (82/83), respectively. The AR expression was positively correlated with age(rs=0.302, P=0.006)and pathological grade (rs=0.225, P=0.041), but was not correlated with tumor size or lymph node status. The Stathmin expression was not correlated with age, tumor size, lymph node status, or pathological grade (P>0.05) . Conclusions The AR expression is correlated with the age or pathological grade but Stathmin expression was all not correlated with the clinicopathologic features. AR or Stathmin as a prognosis indicator in patients with TNBC are needed to more research.

    Release date:2016-09-08 10:35 Export PDF Favorites Scan
  • 狄诺塞麦在乳腺癌中的应用

    【摘要】 狄诺塞麦是目前第一个也是唯一获批的特异性靶向核因子κB受体活化因子配体抑制剂类药物。在乳腺癌的治疗中,无论是对于癌症治疗相关性的骨质疏松或者骨转移,狄诺塞麦都能起到很好的治疗作用,具有广阔的应用前景。现就狄诺塞麦的药理特性、治疗机制、临床试验及效果作一阐述。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
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