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find Keyword "光动力治疗" 4 results
  • Experimental Study of the Therapeutic Effect and Mechanism of Photodynamic therapy to Pancreatic Cancer by Intratumoral Injecting Photosensitizer

    bjectiveTo study the therapeutic effect and mechanism of photodynamic therapy (PDT) to the nude mice model of pancreatic cancer by intratumoral injecting photosensitizers hematoporphyrin derivatives (HpD), hypocrellin A (HA) and 2butylamino2demethoxyhypocrellin A (2BA2DMHA).MethodsThe animal model of human pancreatic cancer was developed by injecting human pancreatic cancer cells SW1990 into the back of the nude mice. After photosensitizers HpD, HA and 2BA2DMHA was given by the intratumoral injection, the 632.8 nm HeNe laser was used to irradiate the tumor. The curative effect was recorded and factorⅧ was used in the immunohistochemical staining to study the vessel change. ResultsPDT can destroy the pancreatic neoplasm, the tumor growth rate was significantly reduced after PDT. The immunohistochemical staining showed PDT could make injury to vessel endothelial cell.ConclusionPDT can induce injuries of pancreatic cancer; vascular injury is an important way to exert function.

    Release date:2016-08-28 04:47 Export PDF Favorites Scan
  • 钇铝石榴石晶体激光联合光动力治疗顽固性跖疣临床观察

    目的探讨钇铝石榴石晶体(Nd:YAG)激光联合光动力治疗(PDT)对顽固性跖疣的疗效及安全性。 方法选取2012年5月-2015年5月就诊的38例顽固性跖疣患者予Nd:YAG激光联合PDT,随访3个月后评价疗效。 结果38例患者经过2~6次治疗后痊愈,平均治疗2.8次,其中2次治疗后治愈15例,3次治疗后治愈19例,3次PDT治愈率达89.5%。随访3个月均未见复发及严重不良反应。 结论Nd:YAG激光联合PDT治疗顽固性跖疣疗效好,安全可靠。

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  • A meta-analysis of the efficacy and safety for port wine stains by photodynamic therapy

    ObjectiveTo evaluate the efficacy and safety of photodynamic treatment for port wine stains compared with gold standard pulsed dye laser.MethodsA literature search was performed in PubMed, CENTRAL, Embase, Web of Science, China National Knowledge Infrastructure, CQVIP, and Wanfang to identify the clinical randomized controlled studies on photodynamic therapy, pulsed dye laser, and port wine stains, which were published from the establishment of the databases to April 3rd, 2021, and the outcome measurements included effective rate and incidence of adverse reactions. Data were extracted and meta-analysis was performed with RevMan5.3 software, and the quality of evidence was evaluated according to GRADE standards.ResultsThree randomized controlled studies were included, with a total of 268 cases of port wine stains. Meta-analysis results showed that there was no statistically significant difference in the efficacy [relative risk (RR) =1.08, 95% confidence interval (CI) (0.89, 1.32), P=0.42] or the incidence of pigmentation [RR=1.03, 95%CI (0.65, 1.65), P=0.89] between photodynamic therapy and pulsed dye laser in the treatment of port wine stains.ConclusionsThe effectiveness and the occurrence of pigmentation of photodynamic therapy on port wine stains are not significantly different from those of pulsed dye laser. Photodynamic therapy is an effective and safe method for the treatment of port wine stains. Due to the limited literature included, large-scale prospective clinical trials are still needed to verify the conclusion.

    Release date:2021-05-19 02:45 Export PDF Favorites Scan
  • Pain management strategies of photodynamic therapy for nevus flammeus

    Nevus flammeus is a skin disease caused by congenital skin capillary malformation. In recent years, photodynamic therapy (PDT) has been proved to be effective and safe for this disease, but significant pain in the treatment process is the biggest obstacle to the implementation of this therapy. This article reviews the current pain management strategies in PDT. The current pain management methods include topical anesthesia, cold air analgesia, nerve block and others. Topical anesthesia has weak analgesic effect and short duration in PDT. Cold air analgesia is simple and feasible, but there is potential risk of affecting the treatment effect. The analgesic effect of nerve block is accurate, but the application scenario is limited. For nevus flammeus patients who need PDT, individualized analgesia should be selected according to the patient’s age and treatment scenario.

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