ObjectiveTo understand the status of the nurse facial skin damage because of regular exposure to a variety of environmental damage factors, in order to cause enough attention and find the solution. MethodsBetween January 2013 and June 2014, we used a self-made questionnaire to survey 122 operating room nurses from grade three first-rate hospitals by random sampling on the facial skin damage status. Then, we analyzed the risk factors of operating room nurses facial skin damage and put forward such countermeasures as improving working environment, increasing service facilities, reducing pollution and biological, chemical, psychological factors, and selecting and using surgical masks properly and promoting facial skin protective measures. ResultsThe survey showed that 93.3% of all the investigated operating room nurses had facial skin problems which mainly was rough dry skin (99.2%); 76.7% of the nurses thought that it was related to the nature of work, and 72.5% of them considered that metal fatigue was the main influence factor. ConclusionWe should strengthen the nurses’ own protection consciousness, enact all kinds of protective measures, strictly implement the system of protection and take effective protective measures as to reduce the operating room nurses facial skin damage.