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find Keyword "全肺灌洗" 7 results
  • 再次全肺灌洗治疗肺泡蛋白沉积症一例

    肺泡蛋白沉积症(PAP)是一种罕见的呼吸系统疾病,主要是由于肺泡腔中大量的嗜酸性富含脂质和蛋白质的物质沉积[1],可分为先天性、继发性和获得性三类。目前PAP最有效的治疗是全肺灌洗[2]。多数文献报道的是对初次诊断的PAP患者的全肺灌洗治疗。2005年我们收治了1例PAP患者,经全肺灌洗治疗10个月后复诊,根据其影像学表现再次进行全肺灌洗治疗,现报告如下。

    Release date:2016-08-30 11:35 Export PDF Favorites Scan
  • 全肺灌洗术联合皮下注射重组人粒细胞-巨噬细胞集落刺激因子治疗原发性肺泡蛋白沉积症一例并文献复习

    肺泡蛋白沉积症(PAP)是一种罕见的疾病,其特征是肺泡内间歇蓄积PAS染色阳性的富含磷脂的蛋白质样物质,从而影响到肺泡的气体交换,导致呼吸困难、低氧血症等一系列临床综合征。PAP可分为原发性、继发性和先天性三种类型,其中90%是原发性PAP,其发病原因不明。目前原发性PAP最常用的治疗方法是全肺灌洗术,但该治疗需在全身麻醉下进行,设备要求高,有一定的风险,且疗效难以持久。现报告1例经过全肺灌洗术后效果不佳,再联合皮下注射重组人粒细胞-巨噬细胞集落刺激因子(rHuGlV1.CSF,特尔立,厦门特宝生物工程有限公司)治疗后病情明显好转的原发性PAP患者,并结合相关文献,以加深对这种新疗法的认识。

    Release date:2016-09-14 11:56 Export PDF Favorites Scan
  • Efficacy and Safety of Whole Lung Lavage in Treatment of Pulmonary Alveolar Proteinosis

    Objective To evaluate the efficacy and safety of whole lung lavage in the treatment of pulmonary alveolar proteinosis ( PAP) .Methods Twelve patients who were diagnosed as PAP from September 2008 to October 2011 in Hunan Occupational Disease Hospital were recruited in the study. The changes of dyspnea symptom, lung-function, arterial blood gas, and chest image were compared before and after whole lung lavage treatment. Meanwhile, the safety of lung lavage was evaluated. Results All patients were relieved from dyspnea. The lung function, hypoxia, hyperventilation, and chest image were all obviously improved. The vital signs in the process of lung lavage were stable without serious complications. Conclusion Whole lung lavage is an effective and safe treatment for PAP.

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  • Clinical Analysis of 15 Cases with Pulmonary Alveolar Proteinosis

    目的:肺泡蛋白沉积症(pulmonary alveolar proteinosis,PAP)是一种少见的肺部疾病,由于临床医生认识不足,容易误诊,而PAP通过灌洗治疗常常可获得较好的预后。本文通过分析PAP病例,总结PAP患者的临床特点、影像学表现和治疗方法,以提高该病的诊疗水平。方法:回顾性分析2003年2月~2008年5月四川大学华西医院呼吸科经病理确诊的15例PAP患者临床资料,并观察了全肺灌洗治疗PAP的效果。结果:PAP患者常见临床症状为咳嗽和进行性呼吸困难,体征正常或无特异性。胸部CT可表现为“地图样”、“铺路石样”或间质纤维化改变。全肺灌洗治疗的14例患者临床症状明显缓解。结论:肺泡蛋白沉积症虽然少见,但只要提高认识,诊断并不困难。支气管肺泡灌洗和(或)肺活检是确诊PAP的重要方法,全肺灌洗是治疗PAP的主要方法。

    Release date:2016-09-08 09:54 Export PDF Favorites Scan
  • 全肺灌洗治疗吸入性肺炎一例

    Release date:2016-09-13 04:00 Export PDF Favorites Scan
  • Diagnosis and Treatment of Pulmonary Alveolar Proteinosis:Analysis of 34 Cases

    ObjectiveTo improve the diagnosis and treatment of pulmonary alveolar proteinosis (PAP). MethodsThe clinical data of 34 PAP cases diagnosed between May 2008 and June 2015 in Hunan Prevention and Treatment Center for Occupational Diseases were retrospectively analyzed. ResultsThere were 34(52.9%)patients with a history of dust exposure. Cough and progressive dyspnea were common clinical symptoms. The incidence rate of hypoxemia and lung function damage was 87.9% and 90.9%,respectively. High resolution CT clearly demonstrated the characteristic map-like changing and paving-stone sign. Arterial blood oxygen partial pressure increased from (62.5±12.9)mm Hg to (73.0±12.2)mm Hg,and DLCO%pred increased from (50.1±14.9)% to (64.6±14.4)% after large-volume whole lung lavage. The recurrence rate was 38.2%. ConclusionThe etiology of PAP is unknown,dust exposure may be associated with secondary PAP. The effect of whole lung lavage is remarkable but the recurrence rate is high. It is needed to study further on etiological treatment of PAP.

    Release date:2016-10-12 10:17 Export PDF Favorites Scan
  • 粒细胞-巨噬细胞集落刺激因子吸入治疗肺泡蛋白沉积症两例

    Release date:2020-02-24 05:02 Export PDF Favorites Scan
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